Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LOXL2
  • Mouse genes Loxl2
  • Rat genes Loxl2
  • Zfish genes loxl2a,loxl2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Loxl2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	LOXL2	IDA		Human	PMID:29581294
Molecular Function	GO:0005507	copper ion binding	LOXL2	IDA		Human	PMID:29581294
Molecular Function	GO:0070492	oligosaccharide binding	LOXL2	IDA		Human	PMID:23319596
Molecular Function	GO:0005515	protein binding	LOXL2	IPI	UniProtKB:O95863	Human	PMID:16096638
Molecular Function	GO:0005515	protein binding	LOXL2	IPI	UniProtKB:P49006	Human	PMID:24863880
Molecular Function	GO:0005515	protein binding	LOXL2	IPI	UniProtKB:O95967	Human	PMID:27339457
Molecular Function	GO:0005515	protein binding	LOXL2	IPI	UniProtKB:P15502-2	Human	PMID:30676771
Molecular Function	GO:0005515	protein binding	LOXL2	IPI	UniProtKB:P02751	Human	PMID:31759052
Molecular Function	GO:0004720	protein-lysine 6-oxidase activity	LOXL2	IDA		Human	PMID:23319596
Molecular Function	GO:0004720	protein-lysine 6-oxidase activity	LOXL2	IDA		Human	PMID:25959397
Molecular Function	GO:0004720	protein-lysine 6-oxidase activity	LOXL2	IDA		Human	PMID:27735137
Molecular Function	GO:0004720	protein-lysine 6-oxidase activity	LOXL2	IDA		Human	PMID:29581294
Cellular Component	GO:0005604	basement membrane	Loxl2	IDA		Rat	PMID:21835952|RGD:8553848
Cellular Component	GO:0000785	chromatin	LOXL2	IDA		Human	PMID:27735137
Cellular Component	GO:0062023	collagen-containing extracellular matrix	LOXL2	HDA		Human	PMID:28327460
Cellular Component	GO:0062023	collagen-containing extracellular matrix	LOXL2	HDA		Human	PMID:23979707
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Loxl2	HDA		Mouse	MGI:MGI:6201853|PMID:28071719
Cellular Component	GO:0005783	endoplasmic reticulum	LOXL2	IDA		Human	PMID:28332555
Cellular Component	GO:0005615	extracellular space	LOXL2	IDA		Human	PMID:23319596
Cellular Component	GO:0005615	extracellular space	Loxl2	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005654	nucleoplasm	LOXL2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	LOXL2	IDA		Human	PMID:22204712
Cellular Component	GO:0005634	nucleus	LOXL2	IDA		Human	PMID:24414204
Biological Process	GO:0030199	collagen fibril organization	LOXL2	IMP		Human	PMID:21835952
Biological Process	GO:0043542	endothelial cell migration	LOXL2	IMP		Human	PMID:21835952
Biological Process	GO:0001935	endothelial cell proliferation	LOXL2	IMP		Human	PMID:21835952
Biological Process	GO:0001837	epithelial to mesenchymal transition	LOXL2	IDA		Human	PMID:16096638
Biological Process	GO:0070828	heterochromatin organization	LOXL2	IMP		Human	PMID:24239292
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	LOXL2	IDA		Human	PMID:16096638
Biological Process	GO:1902455	negative regulation of stem cell population maintenance	Loxl2	IDA		Mouse	MGI:MGI:6107312|PMID:25959397
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	LOXL2	IDA		Human	PMID:25959397
Biological Process	GO:0018057	peptidyl-lysine oxidation	LOXL2	IDA		Human	PMID:25959397
Biological Process	GO:0018057	peptidyl-lysine oxidation	LOXL2	IDA		Human	PMID:27735137
Biological Process	GO:0018057	peptidyl-lysine oxidation	LOXL2	IDA		Human	PMID:29581294
Biological Process	GO:0032332	positive regulation of chondrocyte differentiation	Loxl2	IMP		Mouse	MGI:MGI:5320274|PMID:21071451
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	LOXL2	IMP		Human	PMID:24239292
Biological Process	GO:0036211	protein modification process	LOXL2	IDA		Human	PMID:23319596
Biological Process	GO:0046688	response to copper ion	LOXL2	IDA		Human	PMID:23319596
Biological Process	GO:0001666	response to hypoxia	Loxl2	IDA		Mouse	MGI:MGI:5320262|PMID:21835952
Biological Process	GO:0002040	sprouting angiogenesis	LOXL2	IMP		Human	PMID:21835952
Biological Process	GO:0002040	sprouting angiogenesis	loxl2a	IMP		Zfish	PMID:21835952|ZFIN:ZDB-PUB-110816-15
Biological Process	GO:0002040	sprouting angiogenesis	loxl2a	IMP	ZFIN:ZDB-MRPHLNO-121101-2	Zfish	PMID:21835952

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern