Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LPL
  • Mouse genes Lpl
  • Rat genes Lpl
  • Zfish genes lpl
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lpl

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0034185	apolipoprotein binding	LPL	IPI	UniProtKB:Q6Q788	Human	PMID:15178420
Molecular Function	GO:0005509	calcium ion binding	LPL	IDA		Human	PMID:16179346
Molecular Function	GO:0005509	calcium ion binding	LPL	IDA		Human	PMID:30559189
Molecular Function	GO:0043395	heparan sulfate proteoglycan binding	LPL	IMP		Human	PMID:11342582
Molecular Function	GO:0008201	heparin binding	LPL	IDA		Human	PMID:11342582
Molecular Function	GO:0008201	heparin binding	LPL	IDA		Human	PMID:12573449
Molecular Function	GO:0008201	heparin binding	LPL	IDA		Human	PMID:2110364
Molecular Function	GO:0004465	lipoprotein lipase activity	LPL	IDA		Human	PMID:11342582
Molecular Function	GO:0004465	lipoprotein lipase activity	LPL	IDA		Human	PMID:2110364
Molecular Function	GO:0004465	lipoprotein lipase activity	LPL	IDA		Human	PMID:2340307
Molecular Function	GO:0004465	lipoprotein lipase activity	LPL	IMP		Human	PMID:25149060
Molecular Function	GO:0004465	lipoprotein lipase activity	LPL	IDA		Human	PMID:27578112
Molecular Function	GO:0004465	lipoprotein lipase activity	LPL	IDA		Human	PMID:30559189
Molecular Function	GO:0004465	lipoprotein lipase activity	LPL	IDA		Human	PMID:3973011
Molecular Function	GO:0004465	lipoprotein lipase activity	Lpl	IDA		Mouse	PMID:2563260
Molecular Function	GO:0004465	lipoprotein lipase activity	Lpl	IDA		Mouse	PMID:16166565
Molecular Function	GO:0004465	lipoprotein lipase activity	Lpl	IDA		Rat	PMID:11788374|RGD:70246
Molecular Function	GO:0004465	lipoprotein lipase activity	Lpl	IDA		Rat	PMID:12551943|RGD:1580532
Molecular Function	GO:0004465	lipoprotein lipase activity	Lpl	IDA		Rat	PMID:21569266|RGD:10047183
Molecular Function	GO:0071813	lipoprotein particle binding	LPL	IDA		Human	PMID:11342582
Molecular Function	GO:0008970	phospholipase A1 activity	LPL	IDA		Human	PMID:12032167
Molecular Function	GO:0008970	phospholipase A1 activity	LPL	IDA		Human	PMID:7592706
Molecular Function	GO:0005515	protein binding	LPL	IPI	UniProtKB:Q8IV16	Human	PMID:20124439
Molecular Function	GO:0005515	protein binding	LPL	IPI	UniProtKB:Q92673	Human	PMID:21385844
Molecular Function	GO:0005515	protein binding	LPL	IPI	UniProtKB:Q8IV16	Human	PMID:30559189
Molecular Function	GO:0005515	protein binding	LPL	IPI	UniProtKB:C9J082	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LPL	IPI	UniProtKB:O00233	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LPL	IPI	UniProtKB:O00746	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LPL	IPI	UniProtKB:O14744	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LPL	IPI	UniProtKB:O43493-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LPL	IPI	UniProtKB:Q8IYM2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LPL	IPI	UniProtKB:Q8N0U8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LPL	IPI	UniProtKB:Q8NFB2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LPL	IPI	UniProtKB:Q8TAB7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LPL	IPI	UniProtKB:Q8TAS3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LPL	IPI	UniProtKB:Q9UI10	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LPL	IPI	UniProtKB:Q9UMY4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Lpl	IPI	PR:Q3U3R4	Mouse	PMID:19783858
Molecular Function	GO:0042803	protein homodimerization activity	LPL	IDA		Human	PMID:16179346
Molecular Function	GO:0005102	signaling receptor binding	LPL	IPI	UniProtKB:Q99523	Human	PMID:10085125
Molecular Function	GO:0017129	triglyceride binding	Lpl	IDA		Rat	PMID:12551943|RGD:1580532
Molecular Function	GO:0004806	triglyceride lipase activity	LPL	IDA		Human	PMID:12032167
Molecular Function	GO:0004806	triglyceride lipase activity	LPL	IDA		Human	PMID:12573449
Molecular Function	GO:0004806	triglyceride lipase activity	LPL	IDA		Human	PMID:182536
Molecular Function	GO:0004806	triglyceride lipase activity	LPL	IDA		Human	PMID:7592706
Molecular Function	GO:0004806	triglyceride lipase activity	Lpl	IDA		Mouse	MGI:MGI:3043892|PMID:15178420
Cellular Component	GO:1902494	catalytic complex	LPL	IPI		Human	PMID:30559189
Cellular Component	GO:0009986	cell surface	Lpl	IDA		Mouse	MGI:MGI:4820887|PMID:20620994
Cellular Component	GO:0005615	extracellular space	LPL	IDA		Human	PMID:11342582
Cellular Component	GO:0005615	extracellular space	LPL	IDA		Human	PMID:12573449
Cellular Component	GO:0005615	extracellular space	LPL	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	LPL	IDA		Human	PMID:2340307
Cellular Component	GO:0005615	extracellular space	LPL	IDA		Human	PMID:27578112
Cellular Component	GO:0005615	extracellular space	LPL	IDA		Human	PMID:30559189
Cellular Component	GO:0005615	extracellular space	Lpl	IDA		Mouse	MGI:MGI:3043892|PMID:15178420
Cellular Component	GO:0005615	extracellular space	Lpl	IDA		Rat	PMID:12551943|RGD:1580532
Biological Process	GO:0071398	cellular response to fatty acid	Lpl	IDA		Mouse	MGI:MGI:6282942|PMID:21986524
Biological Process	GO:0031670	cellular response to nutrient	Lpl	IDA		Mouse	MGI:MGI:6282942|PMID:21986524
Biological Process	GO:0042632	cholesterol homeostasis	LPL	IMP		Human	PMID:25149060
Biological Process	GO:0034371	chylomicron remodeling	LPL	IMP		Human	PMID:11342582
Biological Process	GO:0060216	definitive hemopoiesis	lpl	IMP	ZFIN:ZDB-GENO-190507-2	Zfish	PMID:29615667
Biological Process	GO:0006633	fatty acid biosynthetic process	LPL	IDA		Human	PMID:182536
Biological Process	GO:0006631	fatty acid metabolic process	LPL	IDA		Human	PMID:11342582
Biological Process	GO:0006631	fatty acid metabolic process	LPL	IDA		Human	PMID:27578112
Biological Process	GO:0016042	lipid catabolic process	Lpl	IDA		Rat	PMID:12551943|RGD:1580532
Biological Process	GO:0055096	low-density lipoprotein particle mediated signaling	LPL	IMP		Human	PMID:25149060
Biological Process	GO:1900077	negative regulation of cellular response to insulin stimulus	Lpl	IMP		Rat	PMID:25931001|RGD:13794384
Biological Process	GO:1904179	positive regulation of adipose tissue development	LPL	IMP		Human	PMID:31769250
Biological Process	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	Lpl	IGI	RNAcentral:URS00005C83FD_10090	Mouse	MGI:MGI:6282927|PMID:22963823
Biological Process	GO:0032722	positive regulation of chemokine production	LPL	IMP		Human	PMID:25149060
Biological Process	GO:0010886	positive regulation of cholesterol storage	LPL	IMP		Human	PMID:12573449
Biological Process	GO:0045600	positive regulation of fat cell differentiation	LPL	IMP		Human	PMID:29794473
Biological Process	GO:0045600	positive regulation of fat cell differentiation	LPL	IMP		Human	PMID:31769250
Biological Process	GO:0050729	positive regulation of inflammatory response	Lpl	IGI	UniProtKB:P11152	Mouse	MGI:MGI:6282927|PMID:22963823
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Lpl	IGI	RNAcentral:URS00005C83FD_10090	Mouse	MGI:MGI:6282927|PMID:22963823
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Lpl	IGI	RNAcentral:URS00005C83FD_10090	Mouse	MGI:MGI:6282927|PMID:22963823
Biological Process	GO:0010744	positive regulation of macrophage derived foam cell differentiation	Lpl	IGI	UniProtKB:P35951	Mouse	MGI:MGI:1888585|PMID:10858435
Biological Process	GO:0010890	positive regulation of sequestering of triglyceride	LPL	IMP		Human	PMID:12573449
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Lpl	IGI	RNAcentral:URS00005C83FD_10090	Mouse	MGI:MGI:6282927|PMID:22963823
Biological Process	GO:0061959	response to (R)-carnitine	lpl	IEP		Zfish	PMID:28102299
Biological Process	GO:0009617	response to bacterium	Lpl	IEP		Mouse	PMID:23012479
Biological Process	GO:0009409	response to cold	Lpl	IEP		Rat	PMID:18722549|RGD:7241069
Biological Process	GO:0009410	response to xenobiotic stimulus	Lpl	IEP		Rat	PMID:11016888|RGD:2313581
Biological Process	GO:0019432	triglyceride biosynthetic process	Lpl	IMP		Rat	PMID:11788374|RGD:70246
Biological Process	GO:0019433	triglyceride catabolic process	LPL	IDA		Human	PMID:11342582
Biological Process	GO:0019433	triglyceride catabolic process	LPL	IDA		Human	PMID:182536
Biological Process	GO:0019433	triglyceride catabolic process	LPL	IDA		Human	PMID:2110364
Biological Process	GO:0019433	triglyceride catabolic process	LPL	IDA		Human	PMID:2340307
Biological Process	GO:0019433	triglyceride catabolic process	LPL	IDA		Human	PMID:27578112
Biological Process	GO:0019433	triglyceride catabolic process	LPL	IDA		Human	PMID:30559189
Biological Process	GO:0019433	triglyceride catabolic process	LPL	IDA		Human	PMID:3973011
Biological Process	GO:0019433	triglyceride catabolic process	Lpl	IDA		Mouse	MGI:MGI:3043892|PMID:15178420
Biological Process	GO:0070328	triglyceride homeostasis	LPL	IGI	UniProtKB:P02655	Human	PMID:17018885
Biological Process	GO:0034372	very-low-density lipoprotein particle remodeling	LPL	IDA		Human	PMID:3973011

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern