Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Lrp2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes LRP2
- Mouse genes Lrp2
- Rat genes Lrp2
- Zfish genes lrp2a,lrp2b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lrp2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	LRP2	IDA		Human	PMID:23275343
Molecular Function	GO:0038024	cargo receptor activity	LRP2	EXP		Human	PMID:14528014
Molecular Function	GO:0038024	cargo receptor activity	LRP2	EXP		Human	PMID:8710919
Molecular Function	GO:0030492	hemoglobin binding	Lrp2	IDA		Rat	PMID:11805171\|RGD:2317837
Molecular Function	GO:0042562	hormone binding	Lrp2	IPI	RGD:3000	Rat	PMID:15131016\|RGD:10053635
Molecular Function	GO:0031994	insulin-like growth factor I binding	Lrp2	IDA		Rat	PMID:16306401\|RGD:14697713
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	Lrp2	IPI	RGD:620380	Rat	PMID:22349218\|RGD:7207461
Molecular Function	GO:0016922	nuclear receptor binding	Lrp2	IPI	UniProtKB:P04278	Rat	PMID:16143106\|RGD:13210563
Molecular Function	GO:0030165	PDZ domain binding	Lrp2	IPI	RGD:708538	Rat	PMID:21325834\|RGD:7207463
Molecular Function	GO:0005515	protein binding	LRP2	IPI	UniProtKB:O15392	Human	PMID:23825075
Molecular Function	GO:0005515	protein binding	LRP2	IPI	UniProtKB:P01308	Human	PMID:9773776
Molecular Function	GO:0005515	protein binding	Lrp2	IPI	UniProtKB:P97318\|UniProtKB:Q62108\|UniProtKB:Q9D6K5\|UniProtKB:Q9ERE9\|UniProtKB:Q9WVI9\|UniProtKB:Q9Z0G0	Mouse	MGI:MGI:3687813\|PMID:10827173
Molecular Function	GO:0005515	protein binding	Lrp2	IPI	UniProtKB:P70274	Mouse	MGI:MGI:3783915\|PMID:18174160
Molecular Function	GO:0005515	protein binding	Lrp2	IPI	UniProtKB:P61750	Mouse	MGI:MGI:6467684\|PMID:20048263
Molecular Function	GO:0005515	protein binding	Lrp2	IPI	UniProtKB:P21275	Mouse	MGI:MGI:3525818\|PMID:15623804
Molecular Function	GO:0005515	protein binding	Lrp2	IPI	UniProtKB:P12023\|UniProtKB:Q9QXJ1	Mouse	MGI:MGI:4949595\|PMID:20637285
Molecular Function	GO:0005515	protein binding	Lrp2	IPI	UniProtKB:P21741	Mouse	MGI:MGI:6294421\|PMID:10772929
Molecular Function	GO:0005515	protein binding	Lrp2	IPI	UniProtKB:Q9D4C6	Mouse	MGI:MGI:2450812\|PMID:12508107
Molecular Function	GO:0005515	protein binding	Lrp2	IPI	UniProtKB:Q9Z1R3	Mouse	MGI:MGI:3611102\|PMID:16099815
Molecular Function	GO:0005515	protein binding	Lrp2	IPI	PR:O88307	Mouse	PMID:19047013
Molecular Function	GO:0005515	protein binding	Lrp2	IPI	UniProtKB:O88797	Rat	PMID:10769163\|RGD:7243160
Molecular Function	GO:0005515	protein binding	Lrp2	IPI	RGD:621007	Rat	PMID:11880330\|RGD:7243161
Molecular Function	GO:0005515	protein binding	Lrp2	IPI	UniProtKB:Q9QZ76	Rat	PMID:12724130\|RGD:1299150
Molecular Function	GO:0005515	protein binding	Lrp2	IPI	UniProtKB:D3ZAR1	Rat	PMID:14528014\|RGD:8553370
Molecular Function	GO:0005515	protein binding	Lrp2	IPI	UniProtKB:Q5SW96	Rat	PMID:14528014\|RGD:8553370
Molecular Function	GO:0005515	protein binding	Lrp2	IPI	UniProtKB:O88797	Rat	PMID:16306401\|RGD:14697713
Molecular Function	GO:0005515	protein binding	Lrp2	IPI	UniProtKB:P41350	Rat	PMID:16306401\|RGD:14697713
Molecular Function	GO:0005515	protein binding	Lrp2	IPI	UniProtKB:P50596	Rat	PMID:17324488\|RGD:13210549
Molecular Function	GO:0005515	protein binding	Lrp2	IPI	UniProtKB:P01034	Rat	PMID:17462596\|RGD:13210554
Molecular Function	GO:0005515	protein binding	Lrp2	IPI	RGD:3140	Rat	PMID:19340093\|RGD:6902911
Molecular Function	GO:0005515	protein binding	Lrp2	IPI	UniProtKB:Q9H9E1	Rat	PMID:22649097\|RGD:11558003
Molecular Function	GO:0005515	protein binding	Lrp2	IPI	UniProtKB:P30120	Rat	PMID:28659595\|RGD:13210547
Molecular Function	GO:0005515	protein binding	Lrp2	IPI	UniProtKB:P33436	Rat	PMID:28659595\|RGD:13210547
Molecular Function	GO:0140318	protein transporter activity	Lrp2	IDA		Rat	PMID:16306401\|RGD:14697713
Molecular Function	GO:0044877	protein-containing complex binding	Lrp2	IPI	RGD:3708	Rat	PMID:21372499\|RGD:7243126
Molecular Function	GO:0051087	protein-folding chaperone binding	LRP2	IPI	UniProtKB:P10909	Human	PMID:9228033
Cellular Component	GO:0045177	apical part of cell	Lrp2	IDA		Mouse	PMID:15342463
Cellular Component	GO:0045177	apical part of cell	Lrp2	IDA		Mouse	PMID:15616221
Cellular Component	GO:0045177	apical part of cell	Lrp2	IDA		Mouse	PMID:24586199
Cellular Component	GO:0016324	apical plasma membrane	LRP2	IDA		Human	PMID:23825075
Cellular Component	GO:0016324	apical plasma membrane	Lrp2	IDA		Mouse	MGI:MGI:5299272\|PMID:21938401
Cellular Component	GO:0016324	apical plasma membrane	Lrp2	IDA		Mouse	PMID:15616221
Cellular Component	GO:0016324	apical plasma membrane	Lrp2	IDA		Rat	PMID:10919857\|RGD:1641827
Cellular Component	GO:0016324	apical plasma membrane	Lrp2	IDA		Rat	PMID:12519751\|RGD:13210566
Cellular Component	GO:0016324	apical plasma membrane	Lrp2	IDA		Rat	PMID:19202329\|RGD:13210544
Cellular Component	GO:0030424	axon	Lrp2	IDA		Mouse	MGI:MGI:4949595\|PMID:20637285
Cellular Component	GO:0044295	axonal growth cone	Lrp2	IDA		Rat	PMID:26598525\|RGD:11097297
Cellular Component	GO:0005903	brush border	Lrp2	IDA		Mouse	PMID:12815097
Cellular Component	GO:0005903	brush border	Lrp2	IDA		Rat	PMID:11912251\|RGD:2303813
Cellular Component	GO:0031526	brush border membrane	Lrp2	IDA		Mouse	PMID:10662735
Cellular Component	GO:0031526	brush border membrane	Lrp2	IDA		Rat	PMID:12724130\|RGD:1299150
Cellular Component	GO:0031526	brush border membrane	Lrp2	IDA		Rat	PMID:17453355\|RGD:1641828
Cellular Component	GO:0031526	brush border membrane	Lrp2	IDA		Rat	PMID:6752952\|RGD:13210560
Cellular Component	GO:0009986	cell surface	Lrp2	IDA		Rat	PMID:10766831\|RGD:1641845
Cellular Component	GO:0005905	clathrin-coated pit	Lrp2	IDA		Mouse	PMID:15616221
Cellular Component	GO:0005737	cytoplasm	Lrp2	IDA		Rat	PMID:17453355\|RGD:1641828
Cellular Component	GO:0030425	dendrite	Lrp2	IDA		Mouse	MGI:MGI:4949595\|PMID:20637285
Cellular Component	GO:0030139	endocytic vesicle	Lrp2	IDA		Mouse	PMID:15616221
Cellular Component	GO:0005783	endoplasmic reticulum	Lrp2	IDA		Mouse	PMID:15616221
Cellular Component	GO:0005768	endosome	Lrp2	IDA		Mouse	PMID:12815097
Cellular Component	GO:0005768	endosome	Lrp2	IDA		Mouse	PMID:10766831
Cellular Component	GO:0005768	endosome	Lrp2	IDA		Rat	PMID:17063000\|RGD:1641830
Cellular Component	GO:0009897	external side of plasma membrane	Lrp2	IDA		Mouse	MGI:MGI:3690825\|PMID:16143106
Cellular Component	GO:0009897	external side of plasma membrane	Lrp2	IDA		Mouse	MGI:MGI:5908338\|PMID:20460439
Cellular Component	GO:0070062	extracellular exosome	LRP2	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	LRP2	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	Lrp2	IDA		Rat	PMID:17063000\|RGD:1641830
Cellular Component	GO:0005794	Golgi apparatus	Lrp2	IDA		Mouse	PMID:15616221
Cellular Component	GO:0005765	lysosomal membrane	LRP2	HDA		Human	PMID:17897319
Cellular Component	GO:0016020	membrane	Lrp2	IDA		Mouse	PMID:15082773
Cellular Component	GO:0016020	membrane	Lrp2	IDA		Rat	PMID:11595644\|RGD:628443
Cellular Component	GO:0045121	membrane raft	Lrp2	IDA		Rat	PMID:21372499\|RGD:7243126
Cellular Component	GO:0005886	plasma membrane	Lrp2	IDA		Rat	PMID:17324488\|RGD:13210549
Cellular Component	GO:0032991	protein-containing complex	Lrp2	IDA		Rat	PMID:22349218\|RGD:7207461
Cellular Component	GO:0043235	receptor complex	LRP2	IDA		Human	PMID:23382219
Cellular Component	GO:0043235	receptor complex	Lrp2	IDA		Rat	PMID:19202329\|RGD:13210544
Biological Process	GO:0007568	aging	Lrp2	IEP		Rat	PMID:17453355\|RGD:1641828
Biological Process	GO:0097242	amyloid-beta clearance	Lrp2	IMP		Rat	PMID:16306401\|RGD:14697713
Biological Process	GO:0031100	animal organ regeneration	Lrp2	IEP		Rat	PMID:15266031\|RGD:1641836
Biological Process	GO:0035904	aorta development	Lrp2	IMP		Mouse	PMID:25807483
Biological Process	GO:0008283	cell population proliferation	Lrp2	IMP	MGI:MGI:1931859	Mouse	PMID:15623804
Biological Process	GO:0071363	cellular response to growth factor stimulus	Lrp2	IMP		Rat	PMID:16306401\|RGD:14697713
Biological Process	GO:0061642	chemoattraction of axon	Lrp2	IMP		Rat	PMID:26598525\|RGD:11097297
Biological Process	GO:0060982	coronary artery morphogenesis	Lrp2	IMP		Mouse	MGI:MGI:5770180\|PMID:26822476
Biological Process	GO:0060976	coronary vasculature development	Lrp2	IMP		Mouse	PMID:25807483
Biological Process	GO:0034311	diol metabolic process	Lrp2	IMP		Mouse	PMID:10052453
Biological Process	GO:0020028	endocytic hemoglobin import into cell	Lrp2	IMP		Rat	PMID:11805171\|RGD:2317837
Biological Process	GO:0006897	endocytosis	Lrp2	IMP		Rat	PMID:15670845\|RGD:1641835
Biological Process	GO:0006897	endocytosis	lrp2a	IMP	ZFIN:ZDB-FISH-210602-4	Zfish	ZFIN:ZDB-PUB-200221-2
Biological Process	GO:0016197	endosomal transport	Lrp2	IMP		Rat	PMID:9039057\|RGD:1641882
Biological Process	GO:1904447	folate import across plasma membrane	Lrp2	IMP		Mouse	MGI:MGI:5603707\|PMID:24639464
Biological Process	GO:0030900	forebrain development	Lrp2	IMP	MGI:MGI:1931859	Mouse	PMID:15623804
Biological Process	GO:0007507	heart development	Lrp2	IMP		Mouse	PMID:25807483
Biological Process	GO:0007507	heart development	lrp2a	IMP	ZFIN:ZDB-MRPHLNO-060919-4	Zfish	PMID:33006316
Biological Process	GO:0046879	hormone secretion	Lrp2	IMP		Rat	PMID:14657389\|RGD:1641837
Biological Process	GO:0001822	kidney development	Lrp2	IMP	MGI:MGI:5560499	Mouse	PMID:27002738
Biological Process	GO:0008584	male gonad development	Lrp2	IMP		Mouse	MGI:MGI:3690825\|PMID:16143106
Biological Process	GO:0030001	metal ion transport	LRP2	IDA		Human	PMID:15126248
Biological Process	GO:0030001	metal ion transport	Lrp2	IDA		Rat	PMID:15126248\|RGD:13210527
Biological Process	GO:0072237	metanephric proximal tubule development	Lrp2	IEP		Rat	PMID:30645697\|RGD:155631307
Biological Process	GO:0043066	negative regulation of apoptotic process	LRP2	IGI	UniProtKB:P05067:PRO_0000000092	Human	PMID:27241555
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Lrp2	IMP		Mouse	MGI:MGI:5908338\|PMID:20460439
Biological Process	GO:0001843	neural tube closure	Lrp2	IMP		Mouse	MGI:MGI:5603707\|PMID:24639464
Biological Process	GO:0140058	neuron projection arborization	Lrp2	IMP		Mouse	MGI:MGI:4949595\|PMID:20637285
Biological Process	GO:0003148	outflow tract septum morphogenesis	Lrp2	IMP		Mouse	MGI:MGI:5770180\|PMID:26822476
Biological Process	GO:0045807	positive regulation of endocytosis	Lrp2	IMP		Rat	PMID:10766831\|RGD:1641845
Biological Process	GO:0140077	positive regulation of lipoprotein transport	Lrp2	IMP		Rat	PMID:10766831\|RGD:1641845
Biological Process	GO:0050769	positive regulation of neurogenesis	Lrp2	IMP		Mouse	MGI:MGI:5908338\|PMID:20460439
Biological Process	GO:0070447	positive regulation of oligodendrocyte progenitor proliferation	Lrp2	IMP		Mouse	MGI:MGI:5319263\|PMID:22354480
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	LRP2	IGI	UniProtKB:P05067:PRO_0000000092	Human	PMID:27241555
Biological Process	GO:0017038	protein import	Lrp2	IMP		Rat	PMID:16128811\|RGD:152985532
Biological Process	GO:0015031	protein transport	LRP2	IDA		Human	PMID:17324488
Biological Process	GO:0015031	protein transport	Lrp2	IDA		Mouse	MGI:MGI:3814816\|PMID:17324488
Biological Process	GO:0061156	pulmonary artery morphogenesis	Lrp2	IMP		Mouse	MGI:MGI:5770180\|PMID:26822476
Biological Process	GO:0006898	receptor-mediated endocytosis	LRP2	IDA		Human	PMID:23825075
Biological Process	GO:0006898	receptor-mediated endocytosis	Lrp2	IMP		Mouse	MGI:MGI:3783915\|PMID:18174160
Biological Process	GO:0006898	receptor-mediated endocytosis	Lrp2	IMP		Mouse	MGI:MGI:3711604\|PMID:17462596
Biological Process	GO:0006898	receptor-mediated endocytosis	Lrp2	IMP		Mouse	MGI:MGI:5908471\|PMID:28659595
Biological Process	GO:0006898	receptor-mediated endocytosis	Lrp2	IMP		Mouse	MGI:MGI:5908346\|PMID:12724130
Biological Process	GO:0006898	receptor-mediated endocytosis	Lrp2	IDA		Mouse	MGI:MGI:3525818\|PMID:15623804
Biological Process	GO:0006898	receptor-mediated endocytosis	Lrp2	IMP		Mouse	PMID:10052453
Biological Process	GO:0006898	receptor-mediated endocytosis	Lrp2	IDA		Rat	PMID:11595644\|RGD:628443
Biological Process	GO:0006898	receptor-mediated endocytosis	Lrp2	IDA		Rat	PMID:11964399\|RGD:13210557
Biological Process	GO:0006898	receptor-mediated endocytosis	Lrp2	IDA		Rat	PMID:12724130\|RGD:1299150
Biological Process	GO:0006898	receptor-mediated endocytosis	Lrp2	IDA		Rat	PMID:15467006\|RGD:13210530
Biological Process	GO:0006898	receptor-mediated endocytosis	Lrp2	IDA		Rat	PMID:16099815\|RGD:13210531
Biological Process	GO:0006898	receptor-mediated endocytosis	Lrp2	IDA		Rat	PMID:16380466\|RGD:13210553
Biological Process	GO:0006898	receptor-mediated endocytosis	Lrp2	IMP		Rat	PMID:16801528\|RGD:13210565
Biological Process	GO:0006898	receptor-mediated endocytosis	Lrp2	IMP		Rat	PMID:17324488\|RGD:13210549
Biological Process	GO:0006898	receptor-mediated endocytosis	Lrp2	IMP		Rat	PMID:17462596\|RGD:13210554
Biological Process	GO:0006898	receptor-mediated endocytosis	Lrp2	IMP		Rat	PMID:18466341\|RGD:13210545
Biological Process	GO:0006898	receptor-mediated endocytosis	Lrp2	IDA		Rat	PMID:28659595\|RGD:13210547
Biological Process	GO:0006898	receptor-mediated endocytosis	Lrp2	IMP		Rat	PMID:8626514\|RGD:8554276
Biological Process	GO:0006898	receptor-mediated endocytosis	lrp2a	IMP	ZFIN:ZDB-GENO-111103-4	Zfish	PMID:21455927
Biological Process	GO:0006898	receptor-mediated endocytosis	lrp2a	IMP	ZFIN:ZDB-MRPHLNO-060919-4,ZFIN:ZDB-MRPHLNO-060919-5	Zfish	PMID:16638803
Biological Process	GO:0006898	receptor-mediated endocytosis	lrp2a	IMP	ZFIN:ZDB-GENO-111103-5	Zfish	PMID:21455927
Biological Process	GO:0070293	renal absorption	lrp2a	IMP	ZFIN:ZDB-GENO-111103-4	Zfish	PMID:21455927
Biological Process	GO:0070293	renal absorption	lrp2a	IMP	ZFIN:ZDB-GENO-111103-5	Zfish	PMID:21455927
Biological Process	GO:0044321	response to leptin	LRP2	IDA		Human	PMID:17324488
Biological Process	GO:0044321	response to leptin	Lrp2	IDA		Mouse	MGI:MGI:3814816\|PMID:17324488
Biological Process	GO:0044321	response to leptin	Lrp2	IMP		Rat	PMID:17324488\|RGD:13210549
Biological Process	GO:0032526	response to retinoic acid	Lrp2	IEP		Rat	PMID:9541123\|RGD:1641848
Biological Process	GO:0033280	response to vitamin D	Lrp2	IEP		Rat	PMID:9541123\|RGD:1641848
Biological Process	GO:0010165	response to X-ray	Lrp2	IDA		Rat	PMID:12121845\|RGD:1641839
Biological Process	GO:0009410	response to xenobiotic stimulus	Lrp2	IEP		Rat	PMID:15266031\|RGD:1641836
Biological Process	GO:0003139	secondary heart field specification	Lrp2	IMP		Mouse	MGI:MGI:5770180\|PMID:26822476
Biological Process	GO:0007605	sensory perception of sound	Lrp2	IMP		Mouse	MGI:MGI:3789816\|PMID:17846082
Biological Process	GO:0045056	transcytosis	Lrp2	IMP		Rat	PMID:14657389\|RGD:1641837
Biological Process	GO:0045056	transcytosis	Lrp2	IMP		Rat	PMID:16306401\|RGD:14697713
Biological Process	GO:0045056	transcytosis	Lrp2	IMP		Rat	PMID:16801528\|RGD:13210565
Biological Process	GO:0060068	vagina development	Lrp2	IMP		Mouse	MGI:MGI:3690825\|PMID:16143106
Biological Process	GO:0003223	ventricular compact myocardium morphogenesis	Lrp2	IMP		Mouse	MGI:MGI:5770180\|PMID:26822476
Biological Process	GO:0003281	ventricular septum development	Lrp2	IMP		Mouse	PMID:25807483
Biological Process	GO:0042359	vitamin D metabolic process	Lrp2	IMP		Mouse	PMID:10052453

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.