Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LRP4
  • Mouse genes Lrp4
  • Rat genes Lrp4
  • Zfish genes lrp4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lrp4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0034185	apolipoprotein binding	Lrp4	IPI	UniProtKB:P02650	Rat	PMID:17889837|RGD:8553452
Molecular Function	GO:0005515	protein binding	LRP4	IPI	UniProtKB:Q9BQB4	Human	PMID:21471202
Molecular Function	GO:0005515	protein binding	LRP4	IPI	UniProtKB:Q9BQB4	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	Lrp4	IPI	UniProtKB:Q9ERE7	Mouse	MGI:MGI:5521402|PMID:24140340
Molecular Function	GO:0005515	protein binding	Lrp4	IPI	UniProtKB:A2ASQ1	Mouse	MGI:MGI:5545965|PMID:21969364
Molecular Function	GO:0005515	protein binding	Lrp4	IPI	UniProtKB:P25304	Mouse	MGI:MGI:3834767|PMID:18848351
Molecular Function	GO:0005515	protein binding	Lrp4	IPI	PR:O88307	Mouse	PMID:19047013
Molecular Function	GO:0005515	protein binding	Lrp4	IPI	UniProtKB:P25304	Rat	PMID:18957220|RGD:10047261
Molecular Function	GO:0005515	protein binding	Lrp4	IPI	UniProtKB:P25304	Rat	PMID:22302937|RGD:8553690
Molecular Function	GO:0042803	protein homodimerization activity	Lrp4	IDA		Mouse	MGI:MGI:3834767|PMID:18848351
Molecular Function	GO:0030971	receptor tyrosine kinase binding	Lrp4	IPI	UniProtKB:Q61006	Mouse	MGI:MGI:5545965|PMID:21969364
Molecular Function	GO:0030971	receptor tyrosine kinase binding	Lrp4	IPI	UniProtKB:Q61006	Mouse	MGI:MGI:3834767|PMID:18848351
Molecular Function	GO:0030971	receptor tyrosine kinase binding	Lrp4	IPI	UniProtKB:Q61006	Rat	PMID:18957220|RGD:10047261
Molecular Function	GO:0097110	scaffold protein binding	Lrp4	IPI	UniProtKB:P31016	Rat	PMID:16819975|RGD:8554698
Molecular Function	GO:0097110	scaffold protein binding	Lrp4	IPI	UniProtKB:Q62696	Rat	PMID:16819975|RGD:8554698
Cellular Component	GO:0009986	cell surface	LRP4	IDA		Human	PMID:20381006
Cellular Component	GO:0009986	cell surface	Lrp4	IDA		Rat	PMID:16819975|RGD:8554698
Cellular Component	GO:0030425	dendrite	Lrp4	IDA		Rat	PMID:16819975|RGD:8554698
Cellular Component	GO:0031594	neuromuscular junction	Lrp4	IDA		Mouse	MGI:MGI:3829843|PMID:18957220
Cellular Component	GO:0043025	neuronal cell body	Lrp4	IDA		Rat	PMID:16819975|RGD:8554698
Cellular Component	GO:0005886	plasma membrane	Lrp4	IDA		Mouse	MGI:MGI:5521402|PMID:24140340
Cellular Component	GO:0005886	plasma membrane	Lrp4	IDA		Mouse	PMID:16263759
Cellular Component	GO:0044853	plasma membrane raft	Lrp4	IDA		Rat	PMID:17889837|RGD:8553452
Cellular Component	GO:0014069	postsynaptic density	Lrp4	IDA		Rat	PMID:16819975|RGD:8554698
Cellular Component	GO:0045202	synapse	lrp4	IMP	ZFIN:ZDB-GENO-080319-1	Zfish	PMID:17918238|ZFIN:ZDB-PUB-071009-14
Cellular Component	GO:0097060	synaptic membrane	Lrp4	IDA		Rat	PMID:16819975|RGD:8554698
Biological Process	GO:0150094	amyloid-beta clearance by cellular catabolic process	LRP4	IMP		Human	PMID:18289866
Biological Process	GO:0048856	anatomical structure development	Lrp4	IMP	MGI:MGI:2661383	Mouse	PMID:17119023
Biological Process	GO:0048856	anatomical structure development	Lrp4	IMP	MGI:MGI:3580702	Mouse	PMID:17119023
Biological Process	GO:0031103	axon regeneration	lrp4	IMP	ZFIN:ZDB-GENO-190325-12	Zfish	PMID:29921864
Biological Process	GO:0048813	dendrite morphogenesis	Lrp4	IMP		Rat	PMID:17889837|RGD:8553452
Biological Process	GO:0009953	dorsal/ventral pattern formation	Lrp4	IMP	MGI:MGI:3621893	Mouse	PMID:16207730
Biological Process	GO:0009953	dorsal/ventral pattern formation	Lrp4	IMP	MGI:MGI:3707955	Mouse	PMID:17119023
Biological Process	GO:0042733	embryonic digit morphogenesis	Lrp4	IMP	MGI:MGI:3580702	Mouse	PMID:16517118
Biological Process	GO:0042733	embryonic digit morphogenesis	Lrp4	IMP	MGI:MGI:2661383	Mouse	PMID:16517118
Biological Process	GO:0030326	embryonic limb morphogenesis	Lrp4	IMP	MGI:MGI:3621893	Mouse	PMID:16207730
Biological Process	GO:0030326	embryonic limb morphogenesis	Lrp4	IMP	MGI:MGI:3707955	Mouse	PMID:17119023
Biological Process	GO:0030326	embryonic limb morphogenesis	Lrp4	IMP	MGI:MGI:3707726	Mouse	PMID:17119023
Biological Process	GO:0007529	establishment of synaptic specificity at neuromuscular junction	lrp4	IMP	ZFIN:ZDB-GENO-160801-2	Zfish	PMID:27151977
Biological Process	GO:0001942	hair follicle development	Lrp4	IMP	MGI:MGI:3580702	Mouse	PMID:17119023
Biological Process	GO:0001942	hair follicle development	Lrp4	IMP	MGI:MGI:2661383	Mouse	PMID:17119023
Biological Process	GO:0001822	kidney development	LRP4	IDA		Human	PMID:20381006
Biological Process	GO:0001822	kidney development	Lrp4	IMP	MGI:MGI:3580702	Mouse	PMID:17119023
Biological Process	GO:0001822	kidney development	Lrp4	IMP	MGI:MGI:2661383	Mouse	PMID:17119023
Biological Process	GO:0060173	limb development	LRP4	IDA		Human	PMID:20381006
Biological Process	GO:0050771	negative regulation of axonogenesis	Lrp4	IMP		Mouse	MGI:MGI:5439235|PMID:22854782
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	LRP4	IDA		Human	PMID:20093106
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	LRP4	IMP		Human	PMID:20381006
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	LRP4	IMP		Human	PMID:21471202
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Lrp4	IDA		Mouse	PMID:20383322
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Lrp4	IGI	MGI:MGI:1329040	Mouse	PMID:20383322
Biological Process	GO:0030279	negative regulation of ossification	LRP4	IMP		Human	PMID:21471202
Biological Process	GO:0007274	neuromuscular synaptic transmission	lrp4	IMP	ZFIN:ZDB-GENO-080319-1	Zfish	PMID:17918238
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Lrp4	IMP	MGI:MGI:3580702	Mouse	PMID:17119023
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Lrp4	IMP	MGI:MGI:2661383	Mouse	PMID:17119023
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Lrp4	IMP		Mouse	MGI:MGI:3829843|PMID:18957220
Biological Process	GO:1901631	positive regulation of presynaptic membrane organization	Lrp4	IDA		Mouse	MGI:MGI:5439235|PMID:22854782
Biological Process	GO:1904395	positive regulation of skeletal muscle acetylcholine-gated channel clustering	Lrp4	IMP		Mouse	MGI:MGI:3829843|PMID:18957220
Biological Process	GO:0097104	postsynaptic membrane assembly	Lrp4	IMP		Mouse	MGI:MGI:5295488|PMID:22038977
Biological Process	GO:0097105	presynaptic membrane assembly	Lrp4	IMP		Mouse	MGI:MGI:5295488|PMID:22038977
Biological Process	GO:0008104	protein localization	Lrp4	IMP	MGI:MGI:2661383	Mouse	PMID:17119023
Biological Process	GO:0008104	protein localization	Lrp4	IMP	MGI:MGI:3580702	Mouse	PMID:17119023
Biological Process	GO:0009954	proximal/distal pattern formation	Lrp4	IMP	MGI:MGI:3707955	Mouse	PMID:17119023
Biological Process	GO:0043113	receptor clustering	Lrp4	IMP	MGI:MGI:2661383	Mouse	PMID:17119023
Biological Process	GO:0043113	receptor clustering	Lrp4	IMP	MGI:MGI:3580702	Mouse	PMID:17119023
Biological Process	GO:0001932	regulation of protein phosphorylation	Lrp4	IMP		Mouse	MGI:MGI:3834767|PMID:18848351
Biological Process	GO:0071340	skeletal muscle acetylcholine-gated channel clustering	Lrp4	IMP		Mouse	MGI:MGI:5295488|PMID:22038977
Biological Process	GO:0071340	skeletal muscle acetylcholine-gated channel clustering	Lrp4	IMP		Mouse	MGI:MGI:5439235|PMID:22854782
Biological Process	GO:0050808	synapse organization	Lrp4	IMP		Rat	PMID:17889837|RGD:8553452
Biological Process	GO:0051124	synaptic assembly at neuromuscular junction	Lrp4	IDA		Mouse	MGI:MGI:3829843|PMID:18957220
Biological Process	GO:0051124	synaptic assembly at neuromuscular junction	Lrp4	IMP	MGI:MGI:2661383	Mouse	PMID:17119023
Biological Process	GO:0051124	synaptic assembly at neuromuscular junction	Lrp4	IMP	MGI:MGI:3580702	Mouse	PMID:17119023
Biological Process	GO:0016055	Wnt signaling pathway	Lrp4	IDA		Mouse	PMID:18508042
Biological Process	GO:0016055	Wnt signaling pathway	Lrp4	IDA		Mouse	PMID:16207730

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern