Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LRP5,LRP5L
  • Mouse genes Lrp5
  • Rat genes Lrp5
  • Zfish genes lrp5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lrp5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0071936	coreceptor activity involved in Wnt signaling pathway	LRP5	IPI	UniProtKB:P04426	Human	PMID:11336703
Molecular Function	GO:0005515	protein binding	LRP5	IPI	UniProtKB:O35625	Human	PMID:11336703
Molecular Function	GO:0005515	protein binding	LRP5	IPI	UniProtKB:O94907	Human	PMID:11433302
Molecular Function	GO:0005515	protein binding	LRP5	IPI	UniProtKB:Q9BQB4	Human	PMID:15908424
Molecular Function	GO:0005515	protein binding	LRP5	IPI	UniProtKB:Q6IMN6	Human	PMID:18762581
Molecular Function	GO:0005515	protein binding	LRP5	IPI	UniProtKB:Q8J025	Human	PMID:20393562
Molecular Function	GO:0005515	protein binding	LRP5	IPI	UniProtKB:Q9BQB4	Human	PMID:21471202
Molecular Function	GO:0005515	protein binding	LRP5	IPI	UniProtKB:Q9BQB4	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	Lrp5	IPI	PR:P15116	Mouse	PMID:19075000
Molecular Function	GO:0005515	protein binding	Lrp5	IPI	PR:O35625	Mouse	PMID:18632848
Molecular Function	GO:0005515	protein binding	Lrp5	IPI	PR:O35625	Mouse	PMID:19075000
Molecular Function	GO:0042813	Wnt receptor activity	LRP5	IDA		Human	PMID:24706814
Molecular Function	GO:0042813	Wnt receptor activity	LRP5	IDA		Human	PMID:25920554
Molecular Function	GO:0042813	Wnt receptor activity	Lrp5	IDA		Mouse	PMID:11956231
Molecular Function	GO:0017147	Wnt-protein binding	LRP5	IPI	UniProtKB:P04426	Human	PMID:11336703
Molecular Function	GO:0017147	Wnt-protein binding	Lrp5	IPI	PR:P22724	Mouse	PMID:11956231
Molecular Function	GO:0017147	Wnt-protein binding	Lrp5	IPI	PR:P04426	Mouse	PMID:11956231
Cellular Component	GO:0005739	mitochondrion	Lrp5	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005886	plasma membrane	LRP5	IDA		Human	PMID:17680723
Cellular Component	GO:0043235	receptor complex	LRP5	IDA		Human	PMID:18762581
Biological Process	GO:0060612	adipose tissue development	LRP5	IMP		Human	PMID:17680723
Biological Process	GO:0006865	amino acid transport	Lrp5	IMP	MGI:MGI:3604604	Mouse	PMID:22272305
Biological Process	GO:0060033	anatomical structure regression	Lrp5	IMP	MGI:MGI:2183279	Mouse	PMID:16163358
Biological Process	GO:0035676	anterior lateral line neuromast hair cell development	lrp5	IMP	ZFIN:ZDB-MRPHLNO-171214-1,ZFIN:ZDB-MRPHLNO-171214-2	Zfish	PMID:28677207
Biological Process	GO:0009952	anterior/posterior pattern specification	Lrp5	IGI	MGI:MGI:1298218	Mouse	PMID:15142971
Biological Process	GO:1902262	apoptotic process involved in blood vessel morphogenesis	Lrp5	IMP	MGI:MGI:2183279	Mouse	PMID:16163358
Biological Process	GO:0048514	blood vessel morphogenesis	Lrp5	IMP	MGI:MGI:3604604	Mouse	PMID:22272305
Biological Process	GO:0060348	bone development	Lrp5	IMP		Mouse	MGI:MGI:4835143|PMID:17700537
Biological Process	GO:0048539	bone marrow development	LRP5	IMP		Human	PMID:17680723
Biological Process	GO:0030282	bone mineralization	lrp5	IMP	ZFIN:ZDB-GENO-230125-2	Zfish	PMID:33957005
Biological Process	GO:0030282	bone mineralization	lrp5	IMP	ZFIN:ZDB-CRISPR-230124-1	Zfish	PMID:33957005
Biological Process	GO:0060349	bone morphogenesis	LRP5	IMP		Human	PMID:19673927
Biological Process	GO:0060349	bone morphogenesis	LRP5	IMP		Human	PMID:20146170
Biological Process	GO:0060349	bone morphogenesis	LRP5	IMP		Human	PMID:20630166
Biological Process	GO:0046849	bone remodeling	Lrp5	IMP	MGI:MGI:2183279	Mouse	PMID:11956231
Biological Process	GO:0046849	bone remodeling	Lrp5	IGI	MGI:MGI:96274	Mouse	PMID:19041748
Biological Process	GO:0046849	bone remodeling	Lrp5	IMP		Mouse	PMID:15207752
Biological Process	GO:0046849	bone remodeling	Lrp5	IMP		Mouse	PMID:12817748
Biological Process	GO:0046849	bone remodeling	Lrp5	IGI	MGI:MGI:1298218	Mouse	PMID:15537447
Biological Process	GO:0046849	bone remodeling	Lrp5	IMP	MGI:MGI:3530598	Mouse	PMID:17147489
Biological Process	GO:0046849	bone remodeling	Lrp5	IMP		Mouse	PMID:17627087
Biological Process	GO:0046849	bone remodeling	Lrp5	IGI	MGI:MGI:98796	Mouse	PMID:19041748
Biological Process	GO:0046849	bone remodeling	Lrp5	IMP	MGI:MGI:3612485	Mouse	PMID:16790443
Biological Process	GO:0060444	branching involved in mammary gland duct morphogenesis	Lrp5	IMP	MGI:MGI:3663738	Mouse	PMID:16973609
Biological Process	GO:0060070	canonical Wnt signaling pathway	LRP5	IDA		Human	PMID:11029007
Biological Process	GO:0060070	canonical Wnt signaling pathway	LRP5	IGI	UniProtKB:P04426	Human	PMID:11336703
Biological Process	GO:0060070	canonical Wnt signaling pathway	LRP5	IDA		Human	PMID:12121999
Biological Process	GO:0060070	canonical Wnt signaling pathway	LRP5	IDA		Human	PMID:12857724
Biological Process	GO:0060070	canonical Wnt signaling pathway	LRP5	IDA		Human	PMID:15908424
Biological Process	GO:0060070	canonical Wnt signaling pathway	LRP5	IGI	UniProtKB:O00755,UniProtKB:P02649	Human	PMID:16805831
Biological Process	GO:0060070	canonical Wnt signaling pathway	LRP5	IMP		Human	PMID:18044981
Biological Process	GO:0060070	canonical Wnt signaling pathway	LRP5	IMP		Human	PMID:19673927
Biological Process	GO:0060070	canonical Wnt signaling pathway	LRP5	IDA		Human	PMID:24706814
Biological Process	GO:0060070	canonical Wnt signaling pathway	LRP5	IDA		Human	PMID:25920554
Biological Process	GO:0060070	canonical Wnt signaling pathway	Lrp5	IGI	MGI:MGI:98961	Mouse	PMID:15923619
Biological Process	GO:0060070	canonical Wnt signaling pathway	Lrp5	IGI	MGI:MGI:2136761	Mouse	PMID:15923619
Biological Process	GO:0060070	canonical Wnt signaling pathway	Lrp5	IDA		Mouse	PMID:15143170
Biological Process	GO:0060070	canonical Wnt signaling pathway	Lrp5	IGI	MGI:MGI:1196625	Mouse	PMID:15923619
Biological Process	GO:0060070	canonical Wnt signaling pathway	Lrp5	IDA		Mouse	PMID:11956231
Biological Process	GO:0060070	canonical Wnt signaling pathway	Lrp5	IMP	MGI:MGI:3663738	Mouse	PMID:16973609
Biological Process	GO:0060070	canonical Wnt signaling pathway	lrp5	IMP	ZFIN:ZDB-MRPHLNO-100308-2	Zfish	PMID:19801552
Biological Process	GO:0051216	cartilage development	lrp5	IMP	ZFIN:ZDB-CRISPR-230124-1	Zfish	PMID:33957005
Biological Process	GO:0051216	cartilage development	lrp5	IMP	ZFIN:ZDB-GENO-230125-2	Zfish	PMID:33957005
Biological Process	GO:0042074	cell migration involved in gastrulation	Lrp5	IGI	MGI:MGI:1298218	Mouse	PMID:15142971
Biological Process	GO:0098609	cell-cell adhesion	Lrp5	IMP	MGI:MGI:3604604	Mouse	PMID:22272305
Biological Process	GO:0060764	cell-cell signaling involved in mammary gland development	Lrp5	IMP	MGI:MGI:3663738	Mouse	PMID:16973609
Biological Process	GO:0042632	cholesterol homeostasis	LRP5	IMP		Human	PMID:18721193
Biological Process	GO:0042632	cholesterol homeostasis	LRP5	IMP		Human	PMID:20146170
Biological Process	GO:0008203	cholesterol metabolic process	Lrp5	IMP	MGI:MGI:2448955	Mouse	PMID:12509515
Biological Process	GO:0042733	embryonic digit morphogenesis	Lrp5	IGI	MGI:MGI:1298218	Mouse	PMID:15142971
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	lrp5	IMP	ZFIN:ZDB-MRPHLNO-151110-1,ZFIN:ZDB-MRPHLNO-151110-2	Zfish	PMID:26121341
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	lrp5	IMP	ZFIN:ZDB-CRISPR-151110-1,ZFIN:ZDB-CRISPR-151110-2	Zfish	PMID:26121341
Biological Process	GO:0060856	establishment of blood-brain barrier	Lrp5	IMP	MGI:MGI:2183279	Mouse	PMID:25083995
Biological Process	GO:1990963	establishment of blood-retinal barrier	Lrp5	IMP	MGI:MGI:2183279	Mouse	PMID:25083995
Biological Process	GO:0035426	extracellular matrix-cell signaling	Lrp5	IDA		Mouse	MGI:MGI:3621833|PMID:15035989
Biological Process	GO:0031101	fin regeneration	lrp5	IMP	ZFIN:ZDB-CRISPR-230124-1	Zfish	PMID:33957005
Biological Process	GO:0031101	fin regeneration	lrp5	IMP	ZFIN:ZDB-GENO-230125-7	Zfish	PMID:33957005
Biological Process	GO:0031101	fin regeneration	lrp5	IMP	ZFIN:ZDB-GENO-230125-5	Zfish	PMID:33957005
Biological Process	GO:0001702	gastrulation with mouth forming second	Lrp5	IGI	MGI:MGI:1298218	Mouse	PMID:15142971
Biological Process	GO:0010467	gene expression	Lrp5	IMP	MGI:MGI:3604604	Mouse	PMID:22272305
Biological Process	GO:0006007	glucose catabolic process	LRP5	IMP		Human	PMID:19673927
Biological Process	GO:0035108	limb morphogenesis	Lrp5	IGI	MGI:MGI:1298218	Mouse	PMID:15537447
Biological Process	GO:0001889	liver development	lrp5	IGI	ZFIN:ZDB-MRPHLNO-060824-3	Zfish	PMID:23484855
Biological Process	GO:0001889	liver development	lrp5	IGI	ZFIN:ZDB-GENO-140424-7	Zfish	PMID:23484855
Biological Process	GO:0001889	liver development	lrp5	IMP	ZFIN:ZDB-MRPHLNO-100308-1	Zfish	PMID:23484855
Biological Process	GO:0060603	mammary gland duct morphogenesis	Lrp5	IGI	MGI:MGI:1298218	Mouse	PMID:19503830
Biological Process	GO:0008078	mesodermal cell migration	Lrp5	IGI	MGI:MGI:1298218	Mouse	PMID:15142971
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	LRP5	IMP		Human	PMID:17680723
Biological Process	GO:0071901	negative regulation of protein serine/threonine kinase activity	LRP5	IMP		Human	PMID:19107203
Biological Process	GO:0001755	neural crest cell migration	lrp5	IMP	ZFIN:ZDB-CRISPR-151110-2	Zfish	PMID:26121341
Biological Process	GO:0001755	neural crest cell migration	lrp5	IMP	ZFIN:ZDB-MRPHLNO-151110-1,ZFIN:ZDB-MRPHLNO-151110-2	Zfish	PMID:26121341
Biological Process	GO:0001755	neural crest cell migration	lrp5	IMP	ZFIN:ZDB-CRISPR-151110-1	Zfish	PMID:26121341
Biological Process	GO:0001755	neural crest cell migration	lrp5	IMP	ZFIN:ZDB-CRISPR-151110-1,ZFIN:ZDB-CRISPR-151110-2	Zfish	PMID:26121341
Biological Process	GO:0110135	Norrin signaling pathway	LRP5	IDA		Human	PMID:15035989
Biological Process	GO:0110135	Norrin signaling pathway	LRP5	IDA		Human	PMID:17955262
Biological Process	GO:0110135	Norrin signaling pathway	Lrp5	IDA		Mouse	MGI:MGI:3621833|PMID:15035989
Biological Process	GO:0002076	osteoblast development	Lrp5	IMP		Mouse	MGI:MGI:4835143|PMID:17700537
Biological Process	GO:0002076	osteoblast development	Lrp5	IMP	MGI:MGI:3612485	Mouse	PMID:16790443
Biological Process	GO:0033687	osteoblast proliferation	Lrp5	IMP	MGI:MGI:2183279	Mouse	PMID:11956231
Biological Process	GO:0032474	otolith morphogenesis	lrp5	IMP	ZFIN:ZDB-MRPHLNO-171214-1,ZFIN:ZDB-MRPHLNO-171214-2	Zfish	PMID:28677207
Biological Process	GO:0008284	positive regulation of cell population proliferation	LRP5	IDA		Human	PMID:9790987
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	Lrp5	IDA		Mouse	MGI:MGI:3621833|PMID:15035989
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	LRP5	IDA		Human	PMID:15035989
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	LRP5	IDA		Human	PMID:17955262
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Lrp5	IDA		Mouse	MGI:MGI:3621833|PMID:15035989
Biological Process	GO:0045600	positive regulation of fat cell differentiation	LRP5	IMP		Human	PMID:17680723
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	LRP5	IMP		Human	PMID:17680723
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	LRP5	IDA		Human	PMID:9790987
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	Lrp5	IMP		Mouse	MGI:MGI:6162346|PMID:26891291
Biological Process	GO:0033690	positive regulation of osteoblast proliferation	Lrp5	IMP	MGI:MGI:2183279	Mouse	PMID:11956231
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	LRP5	IDA		Human	PMID:12857724
Biological Process	GO:0035677	posterior lateral line neuromast hair cell development	lrp5	IMP	ZFIN:ZDB-MRPHLNO-171214-1,ZFIN:ZDB-MRPHLNO-171214-2	Zfish	PMID:28677207
Biological Process	GO:0042981	regulation of apoptotic process	Lrp5	IMP	MGI:MGI:2183279	Mouse	PMID:11956231
Biological Process	GO:0008217	regulation of blood pressure	LRP5	IMP		Human	PMID:18721193
Biological Process	GO:0030500	regulation of bone mineralization	lrp5	IMP	ZFIN:ZDB-GENO-230209-1	Zfish	PMID:36120446
Biological Process	GO:0045124	regulation of bone resorption	lrp5	IMP	ZFIN:ZDB-GENO-230209-1	Zfish	PMID:36120446
Biological Process	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	Lrp5	IMP	MGI:MGI:2448955	Mouse	PMID:12509515
Biological Process	GO:0030111	regulation of Wnt signaling pathway	lrp5	IMP	ZFIN:ZDB-GENO-230125-7	Zfish	PMID:33957005
Biological Process	GO:0030111	regulation of Wnt signaling pathway	lrp5	IMP	ZFIN:ZDB-CRISPR-230124-1	Zfish	PMID:33957005
Biological Process	GO:0043434	response to peptide hormone	Lrp5	IEP		Rat	PMID:15962290|RGD:2298726
Biological Process	GO:0009314	response to radiation	Lrp5	IEP		Rat	PMID:22704852|RGD:7240519
Biological Process	GO:0060042	retina morphogenesis in camera-type eye	LRP5	IMP		Human	PMID:15346351
Biological Process	GO:0061298	retina vasculature development in camera-type eye	Lrp5	IMP	MGI:MGI:2183279	Mouse	PMID:25083995
Biological Process	GO:0061298	retina vasculature development in camera-type eye	Lrp5	IMP	MGI:MGI:3604604	Mouse	PMID:22272305
Biological Process	GO:0061299	retina vasculature morphogenesis in camera-type eye	Lrp5	IGI	MGI:MGI:102570	Mouse	PMID:19837032
Biological Process	GO:0061299	retina vasculature morphogenesis in camera-type eye	Lrp5	IMP	MGI:MGI:2183279	Mouse	PMID:18263894
Biological Process	GO:0061299	retina vasculature morphogenesis in camera-type eye	Lrp5	IMP	MGI:MGI:2183279	Mouse	PMID:11956231
Biological Process	GO:0061299	retina vasculature morphogenesis in camera-type eye	Lrp5	IMP	MGI:MGI:3774282	Mouse	PMID:18263894
Biological Process	GO:0061299	retina vasculature morphogenesis in camera-type eye	Lrp5	IGI	MGI:MGI:108520	Mouse	PMID:19837032
Biological Process	GO:0061299	retina vasculature morphogenesis in camera-type eye	Lrp5	IMP		Rat	PMID:32833527|RGD:40902996
Biological Process	GO:0061304	retinal blood vessel morphogenesis	LRP5	IMP		Human	PMID:15024691
Biological Process	GO:0061304	retinal blood vessel morphogenesis	LRP5	IMP		Human	PMID:15346351
Biological Process	GO:0061304	retinal blood vessel morphogenesis	Lrp5	IMP		Mouse	MGI:MGI:6092915|PMID:27031698
Biological Process	GO:0007605	sensory perception of sound	lrp5	IMP	ZFIN:ZDB-MRPHLNO-171214-1,ZFIN:ZDB-MRPHLNO-171214-2	Zfish	PMID:28677207
Biological Process	GO:0035019	somatic stem cell population maintenance	Lrp5	IMP	MGI:MGI:3663738	Mouse	PMID:19672307
Biological Process	GO:0001944	vasculature development	Lrp5	IMP	MGI:MGI:2183279	Mouse	PMID:16163358
Biological Process	GO:0016055	Wnt signaling pathway	Lrp5	IMP	MGI:MGI:3604604	Mouse	PMID:22272305

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern