Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LRP8
  • Mouse genes Lrp8
  • Rat genes Lrp8
  • Zfish genes lrp8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lrp8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001540	amyloid-beta binding	Lrp8	IPI	PR:P12023	Mouse	PMID:16227578
Molecular Function	GO:0034185	apolipoprotein binding	Lrp8	IDA		Mouse	MGI:MGI:5306330|PMID:10571240
Molecular Function	GO:0048306	calcium-dependent protein binding	Lrp8	IPI	UniProtKB:Q60841	Mouse	MGI:MGI:5306330|PMID:10571240
Molecular Function	GO:0008035	high-density lipoprotein particle binding	Lrp8	IDA		Rat	PMID:2993274|RGD:2302271
Molecular Function	GO:0019894	kinesin binding	Lrp8	IPI	RGD:1308539	Rat	PMID:11238452|RGD:2324636
Molecular Function	GO:0005515	protein binding	LRP8	IPI	UniProtKB:P02649	Human	PMID:12950167
Molecular Function	GO:0005515	protein binding	LRP8	IPI	UniProtKB:Q60841	Human	PMID:17548821
Molecular Function	GO:0005515	protein binding	LRP8	IPI	UniProtKB:P25054	Human	PMID:19116273
Molecular Function	GO:0005515	protein binding	LRP8	IPI	UniProtKB:Q60841	Human	PMID:20223215
Molecular Function	GO:0005515	protein binding	Lrp8	IPI	UniProtKB:Q60841	Mouse	MGI:MGI:5306330|PMID:10571240
Molecular Function	GO:0005515	protein binding	Lrp8	IPI	UniProtKB:P21741	Mouse	MGI:MGI:6294380|PMID:12573468
Molecular Function	GO:0005515	protein binding	Lrp8	IPI	UniProtKB:P02749	Mouse	MGI:MGI:5925884|PMID:20223219
Molecular Function	GO:0005515	protein binding	Lrp8	IPI	UniProtKB:Q60841|UniProtKB:Q99068	Mouse	MGI:MGI:5582185|PMID:10571241
Molecular Function	GO:0005515	protein binding	Lrp8	IPI	UniProtKB:P35438|UniProtKB:Q62108	Mouse	MGI:MGI:3694290|PMID:16332682
Molecular Function	GO:0005515	protein binding	Lrp8	IPI	PR:Q8VCC9	Mouse	PMID:16227578
Molecular Function	GO:0005515	protein binding	Lrp8	IPI	PR:P55302	Mouse	PMID:16227578
Molecular Function	GO:0038025	reelin receptor activity	Lrp8	IMP		Mouse	MGI:MGI:3821675|PMID:18778775
Molecular Function	GO:0030229	very-low-density lipoprotein particle receptor activity	LRP8	IDA		Human	PMID:8626535
Cellular Component	GO:0030424	axon	Lrp8	IDA		Rat	PMID:10867025|RGD:1581103
Cellular Component	GO:0005901	caveola	LRP8	IDA		Human	PMID:11369809
Cellular Component	GO:0009986	cell surface	Lrp8	IDA		Mouse	PMID:16227578
Cellular Component	GO:0030425	dendrite	Lrp8	IDA		Rat	PMID:9822699|RGD:2324679
Cellular Component	GO:0005615	extracellular space	Lrp8	IDA		Mouse	MGI:MGI:3773783|PMID:15950758
Cellular Component	GO:0016020	membrane	LRP8	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Lrp8	IDA		Rat	PMID:10867025|RGD:1581103
Cellular Component	GO:0005875	microtubule associated complex	Lrp8	IDA		Rat	PMID:11238452|RGD:2324636
Cellular Component	GO:0043025	neuronal cell body	Lrp8	IDA		Rat	PMID:10867025|RGD:1581103
Cellular Component	GO:0014069	postsynaptic density	Lrp8	IDA		Rat	PMID:16102539|RGD:2317930
Cellular Component	GO:0043235	receptor complex	LRP8	IDA		Human	PMID:23382219
Biological Process	GO:0021541	ammon gyrus development	Lrp8	IMP		Mouse	MGI:MGI:3821675|PMID:18778775
Biological Process	GO:0071397	cellular response to cholesterol	Lrp8	IEP		Rat	PMID:19414061|RGD:2324627
Biological Process	GO:0071363	cellular response to growth factor stimulus	Lrp8	IEP		Rat	PMID:8626535|RGD:2324688
Biological Process	GO:0021987	cerebral cortex development	Lrp8	IEP		Rat	PMID:20368265|RGD:2324624
Biological Process	GO:0007268	chemical synaptic transmission	Lrp8	IMP		Mouse	MGI:MGI:3821675|PMID:18778775
Biological Process	GO:0048813	dendrite morphogenesis	Lrp8	IMP		Mouse	MGI:MGI:3821675|PMID:18778775
Biological Process	GO:0006897	endocytosis	LRP8	IDA		Human	PMID:8626535
Biological Process	GO:0021766	hippocampus development	Lrp8	IGI	MGI:MGI:109520	Mouse	PMID:17330141
Biological Process	GO:0021819	layer formation in cerebral cortex	Lrp8	IGI	MGI:MGI:109520	Mouse	PMID:17330141
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Lrp8	IMP		Mouse	MGI:MGI:3821675|PMID:18778775
Biological Process	GO:0032793	positive regulation of CREB transcription factor activity	Lrp8	IMP		Mouse	MGI:MGI:5426130|PMID:21852430
Biological Process	GO:1900006	positive regulation of dendrite development	Lrp8	IGI	UniProtKB:P98156	Mouse	MGI:MGI:3821675|PMID:18778775
Biological Process	GO:0061003	positive regulation of dendritic spine morphogenesis	Lrp8	IMP		Mouse	MGI:MGI:5426130|PMID:21852430
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Lrp8	IMP		Mouse	MGI:MGI:5426130|PMID:21852430
Biological Process	GO:0045860	positive regulation of protein kinase activity	Lrp8	IGI	MGI:MGI:103022	Mouse	PMID:12526740
Biological Process	GO:0045860	positive regulation of protein kinase activity	Lrp8	IGI	MGI:MGI:98935	Mouse	PMID:12526740
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	Lrp8	IMP		Mouse	MGI:MGI:5426130|PMID:21852430
Biological Process	GO:0038026	reelin-mediated signaling pathway	Lrp8	IMP		Mouse	MGI:MGI:3821675|PMID:18778775
Biological Process	GO:0038026	reelin-mediated signaling pathway	Lrp8	IMP		Mouse	MGI:MGI:5426130|PMID:21852430
Biological Process	GO:0042981	regulation of apoptotic process	Lrp8	IMP		Mouse	MGI:MGI:6212700|PMID:29336888
Biological Process	GO:0045088	regulation of innate immune response	Lrp8	IMP		Mouse	MGI:MGI:6212700|PMID:29336888
Biological Process	GO:0009410	response to xenobiotic stimulus	Lrp8	IEP		Rat	PMID:20368265|RGD:2324624
Biological Process	GO:0021517	ventral spinal cord development	Lrp8	IEP		Mouse	MGI:MGI:4849611|PMID:20711475

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern