Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LRPAP1
  • Mouse genes Lrpap1
  • Rat genes Lrpap1
  • Zfish genes lrpap1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lrpap1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0035473	lipase binding	Lrpap1	IPI	RGD:10876	Rat	PMID:16517593|RGD:1581933
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	LRPAP1	IDA		Human	PMID:16263759
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	LRPAP1	IDA		Human	PMID:7774585
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	Lrpap1	IPI	PR:PR:Q9JI18	Mouse	PMID:15082773
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	Lrpap1	IPI	PR:Q924X6	Mouse	PMID:16227578
Molecular Function	GO:0005515	protein binding	LRPAP1	IPI	UniProtKB:Q99523	Human	PMID:10085125
Molecular Function	GO:0005515	protein binding	LRPAP1	IPI	UniProtKB:Q92673	Human	PMID:11294867
Molecular Function	GO:0005515	protein binding	LRPAP1	IPI	UniProtKB:Q07954	Human	PMID:17326667
Molecular Function	GO:0005515	protein binding	LRPAP1	IPI	UniProtKB:Q92673	Human	PMID:17326667
Molecular Function	GO:0005515	protein binding	LRPAP1	IPI	UniProtKB:Q99523	Human	PMID:18687776
Molecular Function	GO:0005515	protein binding	LRPAP1	IPI	UniProtKB:Q99523	Human	PMID:19122660
Molecular Function	GO:0005515	protein binding	LRPAP1	IPI	UniProtKB:P01130	Human	PMID:20030366
Molecular Function	GO:0005515	protein binding	LRPAP1	IPI	UniProtKB:Q07954	Human	PMID:20030366
Molecular Function	GO:0005515	protein binding	LRPAP1	IPI	UniProtKB:P98155	Human	PMID:20223215
Molecular Function	GO:0005515	protein binding	LRPAP1	IPI	UniProtKB:Q99523	Human	PMID:20584990
Molecular Function	GO:0005515	protein binding	LRPAP1	IPI	UniProtKB:Q92673	Human	PMID:26858303
Molecular Function	GO:0005515	protein binding	LRPAP1	IPI	UniProtKB:P01130	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	LRPAP1	IPI	UniProtKB:Q07954	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	LRPAP1	IPI	UniProtKB:Q92673	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	LRPAP1	IPI	UniProtKB:Q12797-6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LRPAP1	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LRPAP1	IPI	UniProtKB:P98155	Human	PMID:8083232
Molecular Function	GO:0005515	protein binding	Lrpap1	IPI	UniProtKB:P98155	Rat	PMID:10571241|RGD:10047198
Molecular Function	GO:0005515	protein binding	Lrpap1	IPI	UniProtKB:Q924X6	Rat	PMID:10571241|RGD:10047198
Molecular Function	GO:0048019	receptor antagonist activity	LRPAP1	IDA		Human	PMID:8083232
Molecular Function	GO:0048018	receptor ligand activity	LRPAP1	IDA		Human	PMID:11294867
Molecular Function	GO:0070326	very-low-density lipoprotein particle receptor binding	LRPAP1	IPI	UniProtKB:P98155	Human	PMID:8083232
Cellular Component	GO:0005801	cis-Golgi network	LRPAP1	IDA		Human	PMID:7774585
Cellular Component	GO:0005737	cytoplasm	Lrpap1	IDA		Rat	PMID:7522607|RGD:10412055
Cellular Component	GO:0005783	endoplasmic reticulum	LRPAP1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	LRPAP1	IDA		Human	PMID:7774585
Cellular Component	GO:0005768	endosome	LRPAP1	IDA		Human	PMID:7774585
Cellular Component	GO:0005794	Golgi apparatus	LRPAP1	IDA		Human	PMID:7774585
Cellular Component	GO:0005886	plasma membrane	LRPAP1	IDA		Human	PMID:16263759
Cellular Component	GO:0005791	rough endoplasmic reticulum	Lrpap1	IDA		Rat	PMID:7522607|RGD:10412055
Cellular Component	GO:0048237	rough endoplasmic reticulum lumen	LRPAP1	IDA		Human	PMID:7774585
Cellular Component	GO:0048237	rough endoplasmic reticulum lumen	Lrpap1	IDA		Rat	PMID:8223699|RGD:1641935
Cellular Component	GO:0031982	vesicle	Lrpap1	IDA		Rat	PMID:8223699|RGD:1641935
Biological Process	GO:0150093	amyloid-beta clearance by transcytosis	LRPAP1	IMP		Human	PMID:26005850
Biological Process	GO:1900222	negative regulation of amyloid-beta clearance	LRPAP1	IGI	UniProtKB:Q07954	Human	PMID:19098903
Biological Process	GO:0060548	negative regulation of cell death	LRPAP1	IGI	ComplexPortal:CPX-1134,UniProtKB:P04925,UniProtKB:Q07954	Human	PMID:23386614
Biological Process	GO:0032091	negative regulation of protein binding	LRPAP1	IDA		Human	PMID:8083232
Biological Process	GO:0002091	negative regulation of receptor internalization	LRPAP1	IGI	ComplexPortal:CPX-1134,UniProtKB:P04925	Human	PMID:23386614
Biological Process	GO:0010916	negative regulation of very-low-density lipoprotein particle clearance	LRPAP1	IDA		Human	PMID:8083232
Biological Process	GO:0048259	regulation of receptor-mediated endocytosis	LRPAP1	IDA		Human	PMID:7774585
Biological Process	GO:0007165	signal transduction	LRPAP1	IDA		Human	PMID:11294867

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern