Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LRRC8A
  • Mouse genes Lrrc8a
  • Rat genes Lrrc8a
  • Zfish genes lrrc8aa,lrrc8ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lrrc8a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0140360	cyclic-GMP-AMP transmembrane transporter activity	LRRC8A	IDA		Human	PMID:33171122
Molecular Function	GO:0042802	identical protein binding	LRRC8A	IPI	UniProtKB:Q8IWT6	Human	PMID:24790029
Molecular Function	GO:0042802	identical protein binding	LRRC8A	IPI	UniProtKB:Q8IWT6	Human	PMID:30127360
Molecular Function	GO:0005253	monoatomic anion channel activity	LRRC8A	IMP		Human	PMID:24725410
Molecular Function	GO:0005253	monoatomic anion channel activity	LRRC8A	IMP		Human	PMID:24790029
Molecular Function	GO:0005515	protein binding	LRRC8A	IPI	UniProtKB:Q6NSJ5	Human	PMID:24790029
Molecular Function	GO:0005515	protein binding	LRRC8A	IPI	UniProtKB:Q6P9F7	Human	PMID:24790029
Molecular Function	GO:0005515	protein binding	LRRC8A	IPI	UniProtKB:Q7L1W4	Human	PMID:24790029
Molecular Function	GO:0005515	protein binding	LRRC8A	IPI	UniProtKB:Q8TDW0	Human	PMID:24790029
Molecular Function	GO:0005515	protein binding	LRRC8A	IPI	UniProtKB:Q6P9F7	Human	PMID:28514442
Molecular Function	GO:0005225	volume-sensitive anion channel activity	LRRC8A	IMP		Human	PMID:26824658
Molecular Function	GO:0005225	volume-sensitive anion channel activity	LRRC8A	IMP		Human	PMID:29769723
Molecular Function	GO:0005225	volume-sensitive anion channel activity	LRRC8A	IDA		Human	PMID:30095067
Molecular Function	GO:0005225	volume-sensitive anion channel activity	LRRC8A	IDA		Human	PMID:33139539
Molecular Function	GO:0005225	volume-sensitive anion channel activity	Lrrc8a	IMP		Rat	PMID:28833202|RGD:13673739
Molecular Function	GO:0005225	volume-sensitive anion channel activity	lrrc8aa	IMP	ZFIN:ZDB-MRPHLNO-161201-1	Zfish	PMID:27688432
Molecular Function	GO:0005225	volume-sensitive anion channel activity	lrrc8aa	IMP	ZFIN:ZDB-MRPHLNO-161201-2	Zfish	PMID:27688432
Cellular Component	GO:0009986	cell surface	LRRC8A	IDA		Human	PMID:14660746
Cellular Component	GO:0005765	lysosomal membrane	LRRC8A	IDA		Human	PMID:33139539
Cellular Component	GO:0016020	membrane	LRRC8A	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	LRRC8A	IDA		Human	PMID:30095067
Cellular Component	GO:0034702	monoatomic ion channel complex	LRRC8A	IDA		Human	PMID:24790029
Cellular Component	GO:0005886	plasma membrane	LRRC8A	IDA		Human	PMID:24725410
Cellular Component	GO:0005886	plasma membrane	LRRC8A	IDA		Human	PMID:24790029
Cellular Component	GO:0005886	plasma membrane	LRRC8A	IDA		Human	PMID:33139539
Biological Process	GO:0015810	aspartate transmembrane transport	Lrrc8a	IMP		Rat	PMID:28833202|RGD:13673739
Biological Process	GO:0006884	cell volume homeostasis	LRRC8A	IMP		Human	PMID:24725410
Biological Process	GO:0006884	cell volume homeostasis	LRRC8A	IMP		Human	PMID:24790029
Biological Process	GO:0006884	cell volume homeostasis	LRRC8A	IDA		Human	PMID:33139539
Biological Process	GO:1902476	chloride transmembrane transport	LRRC8A	IDA		Human	PMID:30095067
Biological Process	GO:0140361	cyclic-GMP-AMP transmembrane import across plasma membrane	LRRC8A	IDA		Human	PMID:33171122
Biological Process	GO:0098656	monoatomic anion transmembrane transport	LRRC8A	IMP		Human	PMID:29769723
Biological Process	GO:0098656	monoatomic anion transmembrane transport	LRRC8A	IDA		Human	PMID:30095067
Biological Process	GO:0098656	monoatomic anion transmembrane transport	lrrc8aa	IMP	ZFIN:ZDB-MRPHLNO-161201-1	Zfish	PMID:27688432|ZFIN:ZDB-PUB-161001-4
Biological Process	GO:0006820	monoatomic anion transport	LRRC8A	IMP		Human	PMID:24725410
Biological Process	GO:0006820	monoatomic anion transport	LRRC8A	IMP		Human	PMID:24790029
Biological Process	GO:0034214	protein hexamerization	LRRC8A	IDA		Human	PMID:30095067
Biological Process	GO:0006970	response to osmotic stress	LRRC8A	IMP		Human	PMID:24725410
Biological Process	GO:0006970	response to osmotic stress	LRRC8A	IMP		Human	PMID:24790029
Biological Process	GO:0006970	response to osmotic stress	Lrrc8a	IMP		Rat	PMID:28833202|RGD:13673739
Biological Process	GO:0015734	taurine transport	Lrrc8a	IMP		Rat	PMID:28833202|RGD:13673739

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern