Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LRRC8B
  • Mouse genes Lrrc8b
  • Rat genes Lrrc8b
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lrrc8b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	LRRC8B	IPI	UniProtKB:Q8IWT6	Human	PMID:24790029
Molecular Function	GO:0005515	protein binding	LRRC8B	IPI	UniProtKB:Q8IWT6	Human	PMID:28514442
Molecular Function	GO:0005225	volume-sensitive anion channel activity	LRRC8B	IMP		Human	PMID:28193731
Cellular Component	GO:0005737	cytoplasm	LRRC8B	IDA		Human	PMID:24790029
Cellular Component	GO:0034702	monoatomic ion channel complex	LRRC8B	IMP		Human	PMID:28193731
Cellular Component	GO:0005886	plasma membrane	LRRC8B	IDA		Human	PMID:24790029
Cellular Component	GO:0005886	plasma membrane	LRRC8B	IMP		Human	PMID:28193731
Biological Process	GO:0098656	monoatomic anion transmembrane transport	LRRC8B	IMP		Human	PMID:24790029
Biological Process	GO:0098656	monoatomic anion transmembrane transport	LRRC8B	IMP		Human	PMID:28193731

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern