Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LRRK1
  • Mouse genes Lrrk1
  • Rat genes Lrrk1
  • Zfish genes lrrk1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lrrk1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	LRRK1	IPI	UniProtKB:Q38SD2	Human	PMID:19712061
Molecular Function	GO:0042802	identical protein binding	LRRK1	IPI	UniProtKB:Q38SD2	Human	PMID:22952686
Molecular Function	GO:0005515	protein binding	LRRK1	IPI	UniProtKB:P53355	Human	PMID:19712061
Molecular Function	GO:0005515	protein binding	LRRK1	IPI	UniProtKB:Q5S007	Human	PMID:19712061
Molecular Function	GO:0005515	protein binding	LRRK1	IPI	UniProtKB:Q5S007	Human	PMID:20144646
Molecular Function	GO:0005515	protein binding	LRRK1	IPI	UniProtKB:P00519	Human	PMID:20697350
Molecular Function	GO:0005515	protein binding	LRRK1	IPI	UniProtKB:Q9UL15	Human	PMID:24510904
Molecular Function	GO:0005515	protein binding	LRRK1	IPI	UniProtKB:P00519	Human	PMID:24947832
Molecular Function	GO:0005515	protein binding	LRRK1	IPI	UniProtKB:P00533	Human	PMID:24947832
Molecular Function	GO:0005515	protein binding	LRRK1	IPI	UniProtKB:Q9UL15	Human	PMID:24947832
Molecular Function	GO:0005515	protein binding	Lrrk1	IPI	PR:P41241	Mouse	PMID:23526378
Cellular Component	GO:0005829	cytosol	LRRK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	LRRK1	IDA		Human	GO_REF:0000052
Biological Process	GO:0045453	bone resorption	Lrrk1	IMP	MGI:MGI:5568128	Mouse	PMID:23526378
Biological Process	GO:0035556	intracellular signal transduction	Lrrk1	IGI	MGI:MGI:98397	Mouse	PMID:23526378
Biological Process	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	Lrrk1	IMP	MGI:MGI:5568128	Mouse	PMID:23526378
Biological Process	GO:0036035	osteoclast development	Lrrk1	IMP	MGI:MGI:5568128	Mouse	PMID:23526378
Biological Process	GO:0036035	osteoclast development	Lrrk1	IGI	MGI:MGI:98397	Mouse	PMID:23526378
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Lrrk1	IMP	MGI:MGI:5568128	Mouse	PMID:23526378
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	LRRK1	IGI	UniProtKB:O14640	Human	PMID:22899650
Biological Process	GO:1902533	positive regulation of intracellular signal transduction	Lrrk1	IGI	MGI:MGI:98397	Mouse	PMID:23526378
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Lrrk1	IMP	MGI:MGI:5568128	Mouse	PMID:23526378

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern