Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Lrrk2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes LRRK2
- Mouse genes Lrrk2
- Rat genes Lrrk2
- Zfish genes lrrk2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lrrk2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	LRRK2	IPI	UniProtKB:P62737	Human	PMID:21307259
Molecular Function	GO:1904713	beta-catenin destruction complex binding	Lrrk2	IPI	UniProtKB:O35625\|UniProtKB:Q02248\|UniProtKB:Q9WV60	Mouse	MGI:MGI:5440351\|PMID:22899650
Molecular Function	GO:0030276	clathrin binding	LRRK2	IPI	UniProtKB:Q68FD5	Human	PMID:21307259
Molecular Function	GO:0005525	GTP binding	LRRK2	IDA		Human	PMID:16980962
Molecular Function	GO:0005525	GTP binding	LRRK2	IDA		Human	PMID:17260967
Molecular Function	GO:0005525	GTP binding	LRRK2	IDA		Human	PMID:17442267
Molecular Function	GO:0034211	GTP-dependent protein kinase activity	LRRK2	IMP		Human	PMID:17200152
Molecular Function	GO:0034211	GTP-dependent protein kinase activity	LRRK2	IDA		Human	PMID:17260967
Molecular Function	GO:0005096	GTPase activator activity	LRRK2	IDA		Human	PMID:17442267
Molecular Function	GO:0003924	GTPase activity	LRRK2	IDA		Human	PMID:21048939
Molecular Function	GO:0042802	identical protein binding	LRRK2	IPI	UniProtKB:Q5S007	Human	PMID:16321986
Molecular Function	GO:0042802	identical protein binding	LRRK2	IPI	UniProtKB:Q5S007	Human	PMID:18230735
Molecular Function	GO:0042802	identical protein binding	LRRK2	IPI	UniProtKB:Q5S007	Human	PMID:18397888
Molecular Function	GO:0042802	identical protein binding	LRRK2	IPI	UniProtKB:Q5S007	Human	PMID:19712061
Molecular Function	GO:0042802	identical protein binding	LRRK2	IPI	UniProtKB:Q5S007	Human	PMID:19733152
Molecular Function	GO:0042802	identical protein binding	LRRK2	IPI	UniProtKB:Q5S007	Human	PMID:20515039
Molecular Function	GO:0042802	identical protein binding	LRRK2	IPI	UniProtKB:Q5S007	Human	PMID:21073465
Molecular Function	GO:0042802	identical protein binding	LRRK2	IPI	UniProtKB:Q5S007	Human	PMID:22363216
Molecular Function	GO:0042802	identical protein binding	LRRK2	IPI	UniProtKB:Q5S007	Human	PMID:22952686
Molecular Function	GO:0042802	identical protein binding	LRRK2	IPI	UniProtKB:Q5S007	Human	PMID:23220480
Molecular Function	GO:0042802	identical protein binding	LRRK2	IPI	UniProtKB:Q5S007	Human	PMID:23241358
Molecular Function	GO:0042802	identical protein binding	LRRK2	IPI	UniProtKB:Q5S007	Human	PMID:24275654
Molecular Function	GO:0042802	identical protein binding	LRRK2	IPI	UniProtKB:Q5S007	Human	PMID:24591621
Molecular Function	GO:0042802	identical protein binding	LRRK2	IPI	UniProtKB:Q5S007	Human	PMID:24904275
Molecular Function	GO:0042802	identical protein binding	LRRK2	IPI	UniProtKB:Q5S007	Human	PMID:26824392
Molecular Function	GO:0042802	identical protein binding	LRRK2	IPI	UniProtKB:Q5S007	Human	PMID:27013965
Molecular Function	GO:0042802	identical protein binding	LRRK2	IPI	UniProtKB:Q5S007	Human	PMID:27357661
Molecular Function	GO:0042802	identical protein binding	Lrrk2	IPI	UniProtKB:Q5S006	Mouse	MGI:MGI:5487494\|PMID:22952686
Molecular Function	GO:0042802	identical protein binding	Lrrk2	IPI	UniProtKB:Q5S006	Mouse	MGI:MGI:5487519\|PMID:21390248
Molecular Function	GO:0042802	identical protein binding	Lrrk2	IPI	UniProtKB:Q5S006	Mouse	MGI:MGI:5796059\|PMID:27357661
Molecular Function	GO:0004706	JUN kinase kinase kinase activity	LRRK2	IDA		Human	PMID:19302196
Molecular Function	GO:0016301	kinase activity	LRRK2	IDA		Human	PMID:17114044
Molecular Function	GO:0016301	kinase activity	LRRK2	IMP		Human	PMID:23916833
Molecular Function	GO:0000287	magnesium ion binding	LRRK2	IMP		Human	PMID:28720718
Molecular Function	GO:0004709	MAP kinase kinase kinase activity	LRRK2	IDA		Human	PMID:19302196
Molecular Function	GO:0036479	peroxidase inhibitor activity	LRRK2	IDA		Human	PMID:21850687
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q16543	Human	PMID:16321986
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O60260	Human	PMID:16352719
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P11142	Human	PMID:17400507
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q9UKV8	Human	PMID:17400507
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P61020	Human	PMID:18445495
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P61021	Human	PMID:18445495
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q13158	Human	PMID:19176810
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q9UNE7-1	Human	PMID:19196961
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q9WUD1	Human	PMID:19196961
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q05639	Human	PMID:19559761
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O14640-2	Human	PMID:19625296
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O14641	Human	PMID:19625296
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q92997	Human	PMID:19625296
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P53355	Human	PMID:19712061
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q38SD2	Human	PMID:19712061
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O14733	Human	PMID:20067578
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P46734	Human	PMID:20067578
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P52564	Human	PMID:20067578
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q38SD2	Human	PMID:20144646
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P46734	Human	PMID:20173330
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q13387	Human	PMID:20173330
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q58A65	Human	PMID:20173330
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q9ESN9	Human	PMID:20173330
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q9WVI9	Human	PMID:20173330
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P26038	Human	PMID:20642453
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P27348	Human	PMID:20642453
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P31946	Human	PMID:20642453
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P61981	Human	PMID:20642453
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P62258	Human	PMID:20642453
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P63104	Human	PMID:20642453
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q04917	Human	PMID:20642453
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q16543	Human	PMID:20642453
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q9UKV8	Human	PMID:20671708
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P60953	Human	PMID:21048939
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q14155	Human	PMID:21048939
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q9W596	Human	PMID:21159966
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O35643	Human	PMID:21307259
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O88935	Human	PMID:21307259
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P17426	Human	PMID:21307259
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P17427	Human	PMID:21307259
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P39053	Human	PMID:21307259
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q61548	Human	PMID:21307259
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q80TJ1	Human	PMID:21307259
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q9JIS5	Human	PMID:21307259
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P05141	Human	PMID:21370995
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P12235	Human	PMID:21370995
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P12236	Human	PMID:21370995
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P21796	Human	PMID:21370995
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P30275	Human	PMID:21370995
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P60953	Human	PMID:21454543
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P63000	Human	PMID:21454543
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P02687	Human	PMID:21658387
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P31749	Human	PMID:21658387
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P30048	Human	PMID:21850687
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q13469	Human	PMID:21983832
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O00429	Human	PMID:22228096
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P02687	Human	PMID:22303461
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P10636-8	Human	PMID:22303461
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P26038	Human	PMID:22363216
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q62848	Human	PMID:22363216
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q8N6T3-2	Human	PMID:22363216
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q16543	Human	PMID:22612223
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O00429	Human	PMID:22639965
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O75581	Human	PMID:22899650
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P26038	Human	PMID:22952686
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q99961	Human	PMID:22998870
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q99962	Human	PMID:22998870
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O95218	Human	PMID:23075850
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P27348	Human	PMID:23075850
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P61981	Human	PMID:23075850
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P62258	Human	PMID:23075850
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P63104	Human	PMID:23075850
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q04917	Human	PMID:23075850
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q16543	Human	PMID:23075850
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P37840	Human	PMID:23183827
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P26038	Human	PMID:23241358
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q63481	Human	PMID:23395371
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P11142	Human	PMID:23455607
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O00429	Human	PMID:23813973
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O00429-3	Human	PMID:23813973
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P00634	Human	PMID:23937259
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P62136	Human	PMID:23937259
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O95295	Human	PMID:23949442
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P10636-2	Human	PMID:24113872
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P10636-8	Human	PMID:24113872
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P49841	Human	PMID:24165324
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P04350	Human	PMID:24275654
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P07437	Human	PMID:24275654
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P68371	Human	PMID:24275654
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q13885	Human	PMID:24275654
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q9BUF5	Human	PMID:24275654
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O00429	Human	PMID:24282027
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O60313	Human	PMID:24282027
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O95140	Human	PMID:24282027
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P39053	Human	PMID:24282027
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q05193	Human	PMID:24282027
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q811U4	Human	PMID:24282027
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P17612	Human	PMID:24351927
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P26038	Human	PMID:24351927
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P27348	Human	PMID:24351927
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P61983	Human	PMID:24351927
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P63104	Human	PMID:24351927
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P30048	Human	PMID:24459295
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P12369	Human	PMID:24464040
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P17612	Human	PMID:24464040
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O14966	Human	PMID:24510904
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O14976	Human	PMID:24510904
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O95816	Human	PMID:24510904
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O95817	Human	PMID:24510904
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P05060	Human	PMID:24510904
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P11142	Human	PMID:24510904
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P30084	Human	PMID:24510904
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P31946	Human	PMID:24510904
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P31947	Human	PMID:24510904
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P42679	Human	PMID:24510904
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P63104	Human	PMID:24510904
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q12972	Human	PMID:24510904
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q7L592	Human	PMID:24510904
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q96PY6	Human	PMID:24510904
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q9NQU5	Human	PMID:24510904
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q9NWM3	Human	PMID:24510904
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q9UL15	Human	PMID:24510904
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q9UNE7	Human	PMID:24510904
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P39053	Human	PMID:24687852
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P26038	Human	PMID:24695735
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O00203	Human	PMID:24725412
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P05141	Human	PMID:24725412
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P07195	Human	PMID:24725412
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P12235	Human	PMID:24725412
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P12236	Human	PMID:24725412
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P15880	Human	PMID:24725412
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P23396	Human	PMID:24725412
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P26373	Human	PMID:24725412
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P42677	Human	PMID:24725412
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P49207	Human	PMID:24725412
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P50914	Human	PMID:24725412
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P60866	Human	PMID:24725412
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P62249	Human	PMID:24725412
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P62258	Human	PMID:24725412
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P62266	Human	PMID:24725412
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P62269	Human	PMID:24725412
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P62277	Human	PMID:24725412
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P62280	Human	PMID:24725412
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P62750	Human	PMID:24725412
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P62841	Human	PMID:24725412
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P62888	Human	PMID:24725412
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P62906	Human	PMID:24725412
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q8WUM0	Human	PMID:24725412
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P46821:PRO_0000018605	Human	PMID:24754922
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P41220	Human	PMID:24794857
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P26038	Human	PMID:24904275
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O14976	Human	PMID:24947832
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P05060	Human	PMID:24947832
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P07437	Human	PMID:24947832
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P11142	Human	PMID:24947832
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P27348	Human	PMID:24947832
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P30084	Human	PMID:24947832
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P31946	Human	PMID:24947832
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P42679	Human	PMID:24947832
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P60866	Human	PMID:24947832
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P61981	Human	PMID:24947832
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P62258	Human	PMID:24947832
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P62841	Human	PMID:24947832
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P63104	Human	PMID:24947832
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q8N8V4	Human	PMID:24947832
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q8WUM0	Human	PMID:24947832
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q96PY6	Human	PMID:24947832
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q9BQ70	Human	PMID:24947832
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q9NQU5	Human	PMID:24947832
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q9UKI2	Human	PMID:24947832
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q9UL15	Human	PMID:24947832
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q9Y6A4	Human	PMID:24947832
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P26038	Human	PMID:25009464
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O15027	Human	PMID:25201882
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q13637	Human	PMID:25360523
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P10415-1	Human	PMID:25446991
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P48729-1	Human	PMID:25500533
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q14155	Human	PMID:25500533
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q99962	Human	PMID:25501810
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P61020	Human	PMID:25605758
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P10636	Human	PMID:26014385
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P26038	Human	PMID:26824392
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P61006	Human	PMID:26824392
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P61026	Human	PMID:26824392
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P62841	Human	PMID:26824392
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q6IQ22	Human	PMID:26824392
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q9H0U4	Human	PMID:26824392
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P63151	Human	PMID:26894577
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O75581	Human	PMID:27013965
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q9Y6I7	Human	PMID:27273569
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P61020	Human	PMID:27314038
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P26038	Human	PMID:27357661
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O00203	Human	PMID:27424887
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P31947	Human	PMID:28202711
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P61981	Human	PMID:28202711
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P05067	Human	PMID:28720718
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O14976	Human	PMID:29513927
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O43865	Human	PMID:29513927
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O95218	Human	PMID:29513927
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O95816	Human	PMID:29513927
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P05060	Human	PMID:29513927
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P49406	Human	PMID:29513927
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q13191	Human	PMID:29513927
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q4G0J3	Human	PMID:29513927
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q53GS9	Human	PMID:29513927
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q6P3X3	Human	PMID:29513927
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q71RC2	Human	PMID:29513927
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q7L592	Human	PMID:29513927
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q8N8V4	Human	PMID:29513927
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q9NWM3	Human	PMID:29513927
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q9UKI2	Human	PMID:29513927
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q9UNE7	Human	PMID:29513927
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P11142	Human	PMID:29519959
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q13501	Human	PMID:29519959
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O00429	Human	PMID:29541021
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q04917	Human	PMID:29541021
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O14641	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O15027	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O43865	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O55143	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O60313	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P04350	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P07437	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P15880	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P21796	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P23396	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P26038	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P26373	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P27348	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P30048	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P30084	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P31947	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P42677	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P49207	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P49406	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P60866	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P61026	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P62249	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P62258	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P62269	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P62277	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P62280	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P62888	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P62906	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P63104	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P63151	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P68371	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q05639	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q12972	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q13885	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q4G0J3	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q53GS9	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q6P3X3	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q71RC2	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q8WUM0	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q99961	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q9BQ70	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q9BUF5	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q9H0U4	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q9UNE7	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q9Y6A4	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:O14966	Human	PMID:31552791
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P57729	Human	PMID:31552791
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q13637	Human	PMID:31552791
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P61006	Human	PMID:32017888
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P48730-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:P60896	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q13191	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q8NHS9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LRRK2	IPI	UniProtKB:Q9BUL9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Lrrk2	IPI	UniProtKB:Q9EPJ9	Mouse	MGI:MGI:5318636\|PMID:22363216
Molecular Function	GO:0005515	protein binding	Lrrk2	IPI	UniProtKB:P46460	Mouse	MGI:MGI:5568145\|PMID:24687852
Molecular Function	GO:0005515	protein binding	Lrrk2	IPI	UniProtKB:Q9ES28	Mouse	MGI:MGI:5318010\|PMID:21048939
Molecular Function	GO:0005515	protein binding	Lrrk2	IPI	UniProtKB:O55143\|UniProtKB:P61982\|UniProtKB:P62259\|UniProtKB:P63101\|UniProtKB:P68254\|UniProtKB:P68510\|UniProtKB:Q9CQV8	Mouse	MGI:MGI:6355873\|PMID:31046837
Molecular Function	GO:0005515	protein binding	Lrrk2	IPI	UniProtKB:P31324	Mouse	MGI:MGI:5553024\|PMID:24464040
Molecular Function	GO:0005515	protein binding	Lrrk2	IPI	UniProtKB:Q9EQH3	Mouse	MGI:MGI:5784974\|PMID:23395371
Molecular Function	GO:0005515	protein binding	Lrrk2	IPI	UniProtKB:P51141	Mouse	MGI:MGI:5440351\|PMID:22899650
Molecular Function	GO:0005515	protein binding	Lrrk2	IPI	UniProtKB:Q61062	Mouse	MGI:MGI:5440351\|PMID:22899650
Molecular Function	GO:0005515	protein binding	Lrrk2	IPI	UniProtKB:P46460	Mouse	MGI:MGI:4941068\|PMID:21307259
Molecular Function	GO:0005515	protein binding	Lrrk2	IPI	UniProtKB:Q8K1M6	Mouse	MGI:MGI:6355691\|PMID:29541021
Molecular Function	GO:0005515	protein binding	Lrrk2	IPI	UniProtKB:Q8K1M6	Mouse	MGI:MGI:5538411\|PMID:24282027
Molecular Function	GO:0005515	protein binding	Lrrk2	IPI	UniProtKB:E9QAT4	Mouse	MGI:MGI:5608715\|PMID:25201882
Molecular Function	GO:0005515	protein binding	Lrrk2	IPI	UniProtKB:Q8K1M6	Mouse	MGI:MGI:5431272\|PMID:22639965
Molecular Function	GO:0005515	protein binding	Lrrk2	IPI	UniProtKB:P61982\|UniProtKB:P62259\|UniProtKB:P63101\|UniProtKB:P68254\|UniProtKB:P68510\|UniProtKB:Q9CQV8	Mouse	MGI:MGI:5487519\|PMID:21390248
Molecular Function	GO:0005515	protein binding	Lrrk2	IPI	UniProtKB:P26038	Mouse	MGI:MGI:5586773\|PMID:24794857
Molecular Function	GO:0005515	protein binding	Lrrk2	IPI	UniProtKB:P05067	Mouse	MGI:MGI:6142520\|PMID:28720718
Molecular Function	GO:0005515	protein binding	Lrrk2	IPI	PR:O54927	Mouse	PMID:27273569
Molecular Function	GO:0005515	protein binding	Lrrk2	IPI	PR:Q91YQ1	Mouse	PMID:24510904
Molecular Function	GO:0005515	protein binding	Lrrk2	IPI	PR:Q8CI32	Mouse	PMID:24510904
Molecular Function	GO:0005515	protein binding	Lrrk2	IPI	UniPRotKB:O88895	Mouse	PMID:27798112
Molecular Function	GO:0005515	protein binding	Lrrk2	IPI	PR:Q9EPJ9	Mouse	PMID:22423108
Molecular Function	GO:0042803	protein homodimerization activity	LRRK2	IPI	UniProtKB:Q5S007	Human	PMID:16321986
Molecular Function	GO:0051018	protein kinase A binding	LRRK2	IPI	UniProtKB:P31324	Human	PMID:24464040
Molecular Function	GO:0051018	protein kinase A binding	Lrrk2	IPI	UniProtKB:P31324	Mouse	MGI:MGI:5553024\|PMID:24464040
Molecular Function	GO:0004672	protein kinase activity	LRRK2	IDA		Human	PMID:16269541
Molecular Function	GO:0004672	protein kinase activity	LRRK2	IDA		Human	PMID:16321986
Molecular Function	GO:0004672	protein kinase activity	LRRK2	IDA		Human	PMID:17442267
Molecular Function	GO:0004672	protein kinase activity	LRRK2	IDA		Human	PMID:21850687
Molecular Function	GO:0004672	protein kinase activity	LRRK2	IDA		Human	PMID:25500533
Molecular Function	GO:0004672	protein kinase activity	Lrrk2	IDA		Mouse	PMID:24510904
Molecular Function	GO:0004674	protein serine/threonine kinase activity	LRRK2	IDA		Human	PMID:17200152
Molecular Function	GO:0004674	protein serine/threonine kinase activity	LRRK2	IDA		Human	PMID:19576176
Molecular Function	GO:0004674	protein serine/threonine kinase activity	LRRK2	IDA		Human	PMID:21048939
Molecular Function	GO:0004674	protein serine/threonine kinase activity	LRRK2	IDA		Human	PMID:21850687
Molecular Function	GO:0004674	protein serine/threonine kinase activity	LRRK2	IDA		Human	PMID:22423108
Molecular Function	GO:0004674	protein serine/threonine kinase activity	LRRK2	IDA		Human	PMID:23949442
Molecular Function	GO:0004674	protein serine/threonine kinase activity	LRRK2	EXP		Human	PMID:26751287
Molecular Function	GO:0004674	protein serine/threonine kinase activity	LRRK2	IMP		Human	PMID:28720718
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Lrrk2	IMP		Mouse	MGI:MGI:6142520\|PMID:28720718
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Lrrk2	IDA		Mouse	PMID:27798112
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Lrrk2	IMP		Mouse	PMID:27798112
Molecular Function	GO:0030159	signaling receptor complex adaptor activity	LRRK2	IDA		Human	PMID:22899650
Molecular Function	GO:0031267	small GTPase binding	LRRK2	IPI	UniProtKB:P60953	Human	PMID:21048939
Molecular Function	GO:0031267	small GTPase binding	Lrrk2	IPI	UniProtKB:P60766	Mouse	MGI:MGI:5318010\|PMID:21048939
Molecular Function	GO:0000149	SNARE binding	LRRK2	IPI	UniProtKB:P46460	Human	PMID:21307259
Molecular Function	GO:0017075	syntaxin-1 binding	LRRK2	IPI	UniProtKB:P61264	Human	PMID:21307259
Molecular Function	GO:0044325	transmembrane transporter binding	LRRK2	IPI	UniProtKB:P21796	Human	PMID:21370995
Molecular Function	GO:0044325	transmembrane transporter binding	LRRK2	IPI	UniProtKB:Q8NHX9	Human	PMID:22012985
Molecular Function	GO:0015631	tubulin binding	LRRK2	IDA		Human	PMID:21159966
Cellular Component	GO:0044753	amphisome	LRRK2	IDA		Human	PMID:19640926
Cellular Component	GO:0044754	autolysosome	LRRK2	IDA		Human	PMID:19640926
Cellular Component	GO:0030424	axon	LRRK2	IDA		Human	PMID:17120249
Cellular Component	GO:0030424	axon	Lrrk2	IDA		Rat	PMID:17114044\|RGD:8693357
Cellular Component	GO:0030424	axon	Lrrk2	IDA		Rat	PMID:17120249\|RGD:2289047
Cellular Component	GO:0099400	caveola neck	LRRK2	IDA		Human	PMID:19640926
Cellular Component	GO:0005737	cytoplasm	LRRK2	IDA		Human	PMID:16321986
Cellular Component	GO:0005737	cytoplasm	LRRK2	IDA		Human	PMID:16352719
Cellular Component	GO:0005737	cytoplasm	LRRK2	IDA		Human	PMID:19625296
Cellular Component	GO:0005737	cytoplasm	LRRK2	IMP		Human	PMID:26014385
Cellular Component	GO:0005737	cytoplasm	Lrrk2	IDA		Mouse	PMID:27273569
Cellular Component	GO:0005737	cytoplasm	Lrrk2	IDA		Rat	PMID:17120249\|RGD:2289047
Cellular Component	GO:0032473	cytoplasmic side of mitochondrial outer membrane	LRRK2	IDA		Human	PMID:16269541
Cellular Component	GO:0031410	cytoplasmic vesicle	Lrrk2	IDA		Mouse	MGI:MGI:5572872\|PMID:17120249
Cellular Component	GO:0005829	cytosol	LRRK2	IDA		Human	PMID:21850687
Cellular Component	GO:0005829	cytosol	LRRK2	IDA		Human	PMID:22736029
Cellular Component	GO:0005829	cytosol	LRRK2	IDA		Human	PMID:22899650
Cellular Component	GO:0005829	cytosol	LRRK2	IDA		Human	PMID:24403142
Cellular Component	GO:0030425	dendrite	LRRK2	IDA		Human	PMID:17120249
Cellular Component	GO:0030425	dendrite	Lrrk2	IDA		Mouse	MGI:MGI:5553024\|PMID:24464040
Cellular Component	GO:0030425	dendrite	Lrrk2	IDA		Rat	PMID:17114044\|RGD:8693357
Cellular Component	GO:0030425	dendrite	Lrrk2	IDA		Rat	PMID:17120249\|RGD:2289047
Cellular Component	GO:0032839	dendrite cytoplasm	LRRK2	IDA		Human	PMID:21696411
Cellular Component	GO:0005783	endoplasmic reticulum	LRRK2	IDA		Human	PMID:19640926
Cellular Component	GO:0005783	endoplasmic reticulum	Lrrk2	IDA		Mouse	MGI:MGI:5572872\|PMID:17120249
Cellular Component	GO:0070971	endoplasmic reticulum exit site	LRRK2	IDA		Human	PMID:25201882
Cellular Component	GO:0070971	endoplasmic reticulum exit site	Lrrk2	IDA		Mouse	MGI:MGI:5608715\|PMID:25201882
Cellular Component	GO:0005768	endosome	Lrrk2	IDA		Mouse	MGI:MGI:5572872\|PMID:17120249
Cellular Component	GO:0070062	extracellular exosome	LRRK2	HDA		Human	PMID:19056867
Cellular Component	GO:0005615	extracellular space	LRRK2	HDA		Human	PMID:22664934
Cellular Component	GO:0098978	glutamatergic synapse	Lrrk2	IMP		Mouse	PMID:25501810
Cellular Component	GO:0098978	glutamatergic synapse	Lrrk2	IDA		Mouse	PMID:25501810
Cellular Component	GO:0005794	Golgi apparatus	LRRK2	IDA		Human	PMID:23395371
Cellular Component	GO:0005794	Golgi apparatus	Lrrk2	IDA		Mouse	MGI:MGI:5572872\|PMID:17120249
Cellular Component	GO:0005798	Golgi-associated vesicle	LRRK2	IDA		Human	PMID:24510904
Cellular Component	GO:0030426	growth cone	LRRK2	IDA		Human	PMID:19625296
Cellular Component	GO:0016234	inclusion body	LRRK2	IMP		Human	PMID:24403142
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	LRRK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Lrrk2	IDA		Rat	PMID:17120249\|RGD:2289047
Cellular Component	GO:0005764	lysosome	Lrrk2	IDA		Mouse	MGI:MGI:5572872\|PMID:17120249
Cellular Component	GO:0016020	membrane	Lrrk2	IDA		Rat	PMID:17120249\|RGD:2289047
Cellular Component	GO:0045121	membrane raft	Lrrk2	IDA		Mouse	PMID:17341485
Cellular Component	GO:0005902	microvillus	LRRK2	IDA		Human	PMID:19640926
Cellular Component	GO:0005743	mitochondrial inner membrane	Lrrk2	IDA		Mouse	MGI:MGI:5572872\|PMID:17120249
Cellular Component	GO:0005759	mitochondrial matrix	Lrrk2	IDA		Mouse	MGI:MGI:5572872\|PMID:17120249
Cellular Component	GO:0031966	mitochondrial membrane	LRRK2	IDA		Human	PMID:22736029
Cellular Component	GO:0005741	mitochondrial outer membrane	Lrrk2	IDA		Mouse	MGI:MGI:5572872\|PMID:17120249
Cellular Component	GO:0005739	mitochondrion	LRRK2	IDA		Human	PMID:21850687
Cellular Component	GO:0097487	multivesicular body, internal vesicle	LRRK2	IDA		Human	PMID:19640926
Cellular Component	GO:0043005	neuron projection	LRRK2	IDA		Human	PMID:19625296
Cellular Component	GO:0043005	neuron projection	LRRK2	IDA		Human	PMID:21048939
Cellular Component	GO:0043005	neuron projection	Lrrk2	IDA		Rat	PMID:17120249\|RGD:2289047
Cellular Component	GO:0043005	neuron projection	Lrrk2	IDA		Rat	PMID:18445495\|RGD:13462049
Cellular Component	GO:0043025	neuronal cell body	LRRK2	IDA		Human	PMID:21048939
Cellular Component	GO:0043025	neuronal cell body	LRRK2	IDA		Human	PMID:21696411
Cellular Component	GO:0043025	neuronal cell body	Lrrk2	IDA		Rat	PMID:18445495\|RGD:13462049
Cellular Component	GO:0043204	perikaryon	LRRK2	IDA		Human	PMID:17120249
Cellular Component	GO:0043204	perikaryon	Lrrk2	IDA		Rat	PMID:17114044\|RGD:8693357
Cellular Component	GO:0005886	plasma membrane	LRRK2	IDA		Human	PMID:22899650
Cellular Component	GO:0005886	plasma membrane	Lrrk2	IDA		Mouse	PMID:17341485
Cellular Component	GO:0099523	presynaptic cytosol	Lrrk2	IDA		Mouse	PMID:17341485
Cellular Component	GO:1990904	ribonucleoprotein complex	Lrrk2	IDA		Mouse	PMID:24427314
Cellular Component	GO:0045202	synapse	Lrrk2	IDA		Mouse	PMID:22423108
Cellular Component	GO:0045202	synapse	Lrrk2	IDA		Rat	PMID:18445495\|RGD:13462049
Cellular Component	GO:0008021	synaptic vesicle	Lrrk2	IDA		Mouse	PMID:17341485
Cellular Component	GO:0005802	trans-Golgi network	Lrrk2	IDA		Mouse	PMID:24510904
Cellular Component	GO:0005802	trans-Golgi network	Lrrk2	IDA		Mouse	PMID:17341485
Cellular Component	GO:1990909	Wnt signalosome	LRRK2	IDA		Human	PMID:22899650
Cellular Component	GO:1990909	Wnt signalosome	Lrrk2	IDA		Mouse	MGI:MGI:5440351\|PMID:22899650
Biological Process	GO:0019722	calcium-mediated signaling	LRRK2	IMP		Human	PMID:25416817
Biological Process	GO:1903351	cellular response to dopamine	LRRK2	IMP		Human	PMID:23628791
Biological Process	GO:0071287	cellular response to manganese ion	LRRK2	IMP		Human	PMID:23628791
Biological Process	GO:0071407	cellular response to organic cyclic compound	Lrrk2	IEP		Rat	PMID:19879924\|RGD:5508421
Biological Process	GO:0034599	cellular response to oxidative stress	LRRK2	IMP		Human	PMID:21362567
Biological Process	GO:0034599	cellular response to oxidative stress	LRRK2	IMP		Human	PMID:21857923
Biological Process	GO:0034599	cellular response to oxidative stress	LRRK2	IMP		Human	PMID:22764206
Biological Process	GO:0009267	cellular response to starvation	LRRK2	IMP		Human	PMID:24211199
Biological Process	GO:0008340	determination of adult lifespan	LRRK2	IMP		Human	PMID:19692353
Biological Process	GO:0006897	endocytosis	LRRK2	IGI	UniProtKB:P34216\|UniProtKB:P39013	Human	PMID:24576675
Biological Process	GO:0006897	endocytosis	LRRK2	IMP		Human	PMID:24576675
Biological Process	GO:0007029	endoplasmic reticulum organization	LRRK2	IMP		Human	PMID:25201882
Biological Process	GO:0007029	endoplasmic reticulum organization	Lrrk2	IMP		Mouse	MGI:MGI:5608715\|PMID:25201882
Biological Process	GO:0060079	excitatory postsynaptic potential	Lrrk2	IMP		Mouse	MGI:MGI:5553024\|PMID:24464040
Biological Process	GO:0035640	exploration behavior	LRRK2	IMP		Human	PMID:20659558
Biological Process	GO:0007030	Golgi organization	LRRK2	IMP		Human	PMID:24510904
Biological Process	GO:0007030	Golgi organization	Lrrk2	IGI	MGI:MGI:2385107	Mouse	PMID:24510904
Biological Process	GO:0046039	GTP metabolic process	LRRK2	IDA		Human	PMID:21048939
Biological Process	GO:0048312	intracellular distribution of mitochondria	LRRK2	IMP		Human	PMID:21159966
Biological Process	GO:0035556	intracellular signal transduction	Lrrk2	IMP		Mouse	MGI:MGI:5553024\|PMID:24464040
Biological Process	GO:0007254	JNK cascade	LRRK2	IDA		Human	PMID:19302196
Biological Process	GO:0035641	locomotory exploration behavior	Lrrk2	IMP		Mouse	MGI:MGI:5553024\|PMID:24464040
Biological Process	GO:0007040	lysosome organization	LRRK2	IMP		Human	PMID:25416817
Biological Process	GO:0000165	MAPK cascade	LRRK2	IDA		Human	PMID:17200152
Biological Process	GO:0051646	mitochondrion localization	LRRK2	IMP		Human	PMID:22764206
Biological Process	GO:0007005	mitochondrion organization	LRRK2	IMP		Human	PMID:22764206
Biological Process	GO:1902902	negative regulation of autophagosome assembly	LRRK2	IMP		Human	PMID:23916833
Biological Process	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	LRRK2	IMP		Human	PMID:21857923
Biological Process	GO:0090394	negative regulation of excitatory postsynaptic potential	Lrrk2	IMP		Mouse	MGI:MGI:4941068\|PMID:21307259
Biological Process	GO:0034260	negative regulation of GTPase activity	LRRK2	IDA		Human	PMID:22423108
Biological Process	GO:1903206	negative regulation of hydrogen peroxide-induced cell death	LRRK2	IMP		Human	PMID:24576675
Biological Process	GO:0016242	negative regulation of macroautophagy	LRRK2	IMP		Human	PMID:19640926
Biological Process	GO:1901215	negative regulation of neuron death	LRRK2	IGI	UniProtKB:Q9TZM3	Human	PMID:21857923
Biological Process	GO:0010977	negative regulation of neuron projection development	Lrrk2	IMP		Rat	PMID:17114044\|RGD:8693357
Biological Process	GO:0032091	negative regulation of protein binding	LRRK2	IMP		Human	PMID:23949442
Biological Process	GO:0001933	negative regulation of protein phosphorylation	Lrrk2	IMP		Mouse	MGI:MGI:5553024\|PMID:24464040
Biological Process	GO:0010955	negative regulation of protein processing	LRRK2	IDA		Human	PMID:21370995
Biological Process	GO:1903215	negative regulation of protein targeting to mitochondrion	LRRK2	IDA		Human	PMID:21370995
Biological Process	GO:1903125	negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation	LRRK2	IDA		Human	PMID:21850687
Biological Process	GO:0007528	neuromuscular junction development	LRRK2	IMP		Human	PMID:21159966
Biological Process	GO:0070997	neuron death	LRRK2	IMP		Human	PMID:19692353
Biological Process	GO:0140058	neuron projection arborization	Lrrk2	IMP		Rat	PMID:17114044\|RGD:8693357
Biological Process	GO:0048812	neuron projection morphogenesis	LRRK2	IMP		Human	PMID:17114044
Biological Process	GO:0021772	olfactory bulb development	LRRK2	IMP		Human	PMID:21168496
Biological Process	GO:0018105	peptidyl-serine phosphorylation	LRRK2	IDA		Human	PMID:19576176
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	LRRK2	IDA		Human	PMID:21048939
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	LRRK2	IMP		Human	PMID:23949442
Biological Process	GO:0016310	phosphorylation	LRRK2	IMP		Human	PMID:23916833
Biological Process	GO:0010508	positive regulation of autophagy	LRRK2	IMP		Human	PMID:22012985
Biological Process	GO:0010508	positive regulation of autophagy	Lrrk2	IMP		Mouse	MGI:MGI:4454597\|PMID:20457918
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	LRRK2	IGI	UniProtKB:O14640\|UniProtKB:O14641\|UniProtKB:O75581\|UniProtKB:Q92997	Human	PMID:22899650
Biological Process	GO:0060161	positive regulation of dopamine receptor signaling pathway	LRRK2	IMP		Human	PMID:20659558
Biological Process	GO:0043406	positive regulation of MAP kinase activity	LRRK2	IMP		Human	PMID:21857923
Biological Process	GO:1903980	positive regulation of microglial cell activation	Lrrk2	IMP		Rat	PMID:22302802\|RGD:13462052
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	Lrrk2	IMP		Rat	PMID:22302802\|RGD:13462052
Biological Process	GO:0043068	positive regulation of programmed cell death	LRRK2	IDA		Human	PMID:17200152
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Lrrk2	IMP		Mouse	MGI:MGI:4454597\|PMID:20457918
Biological Process	GO:1902499	positive regulation of protein autoubiquitination	LRRK2	IDA		Human	PMID:16352719
Biological Process	GO:0032092	positive regulation of protein binding	LRRK2	IDA		Human	PMID:21370995
Biological Process	GO:0045860	positive regulation of protein kinase activity	LRRK2	IDA		Human	PMID:19302196
Biological Process	GO:0001934	positive regulation of protein phosphorylation	LRRK2	IMP		Human	PMID:20659558
Biological Process	GO:0001934	positive regulation of protein phosphorylation	LRRK2	IDA		Human	PMID:22012985
Biological Process	GO:0031398	positive regulation of protein ubiquitination	LRRK2	IDA		Human	PMID:16352719
Biological Process	GO:0031398	positive regulation of protein ubiquitination	LRRK2	IDA		Human	PMID:20173330
Biological Process	GO:1900244	positive regulation of synaptic vesicle endocytosis	Lrrk2	IMP		Rat	PMID:18445495\|RGD:13462049
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Lrrk2	IMP		Rat	PMID:22302802\|RGD:13462052
Biological Process	GO:0046777	protein autophosphorylation	LRRK2	IDA		Human	PMID:16269541
Biological Process	GO:0046777	protein autophosphorylation	LRRK2	IDA		Human	PMID:16321986
Biological Process	GO:0046777	protein autophosphorylation	LRRK2	IMP		Human	PMID:16980962
Biological Process	GO:0046777	protein autophosphorylation	LRRK2	IDA		Human	PMID:17200152
Biological Process	GO:0046777	protein autophosphorylation	LRRK2	IDA		Human	PMID:17442267
Biological Process	GO:0006606	protein import into nucleus	Lrrk2	IMP		Mouse	PMID:27798112
Biological Process	GO:0006606	protein import into nucleus	Lrrk2	IDA		Mouse	PMID:27798112
Biological Process	GO:0008104	protein localization	Lrrk2	IMP		Mouse	MGI:MGI:5553024\|PMID:24464040
Biological Process	GO:0070973	protein localization to endoplasmic reticulum exit site	LRRK2	IMP		Human	PMID:25201882
Biological Process	GO:0070973	protein localization to endoplasmic reticulum exit site	Lrrk2	IMP		Mouse	MGI:MGI:5608715\|PMID:25201882
Biological Process	GO:0006468	protein phosphorylation	LRRK2	IMP		Human	PMID:23628791
Biological Process	GO:0006468	protein phosphorylation	LRRK2	IDA		Human	PMID:25500533
Biological Process	GO:0006468	protein phosphorylation	LRRK2	IMP		Human	PMID:28720718
Biological Process	GO:0006468	protein phosphorylation	Lrrk2	IMP		Mouse	MGI:MGI:6142520\|PMID:28720718
Biological Process	GO:0006468	protein phosphorylation	Lrrk2	IMP		Mouse	PMID:27798112
Biological Process	GO:0006468	protein phosphorylation	Lrrk2	IDA		Mouse	PMID:27798112
Biological Process	GO:0072593	reactive oxygen species metabolic process	LRRK2	IMP		Human	PMID:24576675
Biological Process	GO:0010506	regulation of autophagy	LRRK2	IMP		Human	PMID:24211199
Biological Process	GO:2000172	regulation of branching morphogenesis of a nerve	LRRK2	IMP		Human	PMID:21168496
Biological Process	GO:1905289	regulation of CAMKK-AMPK signaling cascade	LRRK2	IMP		Human	PMID:22012985
Biological Process	GO:0060828	regulation of canonical Wnt signaling pathway	Lrrk2	IPI	UniProtKB:O35625\|UniProtKB:P51141\|UniProtKB:Q02248\|UniProtKB:Q9WV60	Mouse	MGI:MGI:5440351\|PMID:22899650
Biological Process	GO:0061001	regulation of dendritic spine morphogenesis	LRRK2	IMP		Human	PMID:21168496
Biological Process	GO:0061001	regulation of dendritic spine morphogenesis	Lrrk2	IGI	UniProtKB:P23528	Mouse	MGI:MGI:5553024\|PMID:24464040
Biological Process	GO:0060159	regulation of dopamine receptor signaling pathway	Lrrk2	IMP		Mouse	MGI:MGI:5553024\|PMID:24464040
Biological Process	GO:0060628	regulation of ER to Golgi vesicle-mediated transport	Lrrk2	IMP		Mouse	MGI:MGI:5608715\|PMID:25201882
Biological Process	GO:0010468	regulation of gene expression	Lrrk2	IMP	MGI:MGI:5644525	Mouse	PMID:24427314
Biological Process	GO:0035564	regulation of kidney size	Lrrk2	IMP		Mouse	MGI:MGI:4454597\|PMID:20457918
Biological Process	GO:0040012	regulation of locomotion	LRRK2	IMP		Human	PMID:19692353
Biological Process	GO:0035751	regulation of lysosomal lumen pH	LRRK2	IMP		Human	PMID:22012985
Biological Process	GO:0042391	regulation of membrane potential	LRRK2	IMP		Human	PMID:21159966
Biological Process	GO:0051900	regulation of mitochondrial depolarization	LRRK2	IMP		Human	PMID:22736029
Biological Process	GO:1902692	regulation of neuroblast proliferation	LRRK2	IMP		Human	PMID:21168496
Biological Process	GO:1901214	regulation of neuron death	LRRK2	IMP		Human	PMID:24403142
Biological Process	GO:0014041	regulation of neuron maturation	LRRK2	IMP		Human	PMID:21168496
Biological Process	GO:0010738	regulation of protein kinase A signaling	Lrrk2	IMP		Mouse	MGI:MGI:5553024\|PMID:24464040
Biological Process	GO:0031647	regulation of protein stability	LRRK2	IMP		Human	PMID:26014385
Biological Process	GO:1905279	regulation of retrograde transport, endosome to Golgi	LRRK2	IGI	UniProtKB:Q7KVL7	Human	PMID:23395371
Biological Process	GO:0051966	regulation of synaptic transmission, glutamatergic	Lrrk2	IMP		Mouse	MGI:MGI:5553024\|PMID:24464040
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	Lrrk2	IMP		Mouse	PMID:25501810
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	Lrrk2	IDA		Mouse	PMID:25501810
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	LRRK2	IMP		Human	PMID:23949442
Biological Process	GO:1902803	regulation of synaptic vesicle transport	Lrrk2	IMP		Mouse	MGI:MGI:4941068\|PMID:21307259
Biological Process	GO:0006979	response to oxidative stress	LRRK2	IMP		Human	PMID:19692353
Biological Process	GO:0007283	spermatogenesis	Lrrk2	IEP		Rat	PMID:20403420\|RGD:13462047
Biological Process	GO:0021756	striatum development	Lrrk2	IEP		Rat	PMID:18272292\|RGD:13462055
Biological Process	GO:0022028	tangential migration from the subventricular zone to the olfactory bulb	LRRK2	IMP		Human	PMID:21168496
Biological Process	GO:1904887	Wnt signalosome assembly	LRRK2	IPI	UniProtKB:O75581	Human	PMID:22899650

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.