Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LTF
  • Mouse genes Ltf
  • Rat genes Ltf
  • Zfish genes tfa
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ltf

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004869	cysteine-type endopeptidase inhibitor activity	LTF	IDA		Human	PMID:12788072
Molecular Function	GO:0008201	heparin binding	LTF	IDA		Human	PMID:11907569
Molecular Function	GO:0005506	iron ion binding	LTF	IDA		Human	PMID:12037568
Molecular Function	GO:0001530	lipopolysaccharide binding	LTF	IMP		Human	PMID:15155221
Molecular Function	GO:0008233	peptidase activity	Ltf	IDA		Mouse	PMID:15572693
Molecular Function	GO:0005515	protein binding	LTF	IPI	UniProtKB:P27958:PRO_0000037570	Human	PMID:12522210
Molecular Function	GO:0005515	protein binding	LTF	IPI	UniProtKB:P62157	Human	PMID:1544444
Molecular Function	GO:0005515	protein binding	LTF	IPI	UniProtKB:O95925	Human	PMID:17567961
Molecular Function	GO:0005515	protein binding	LTF	IPI	UniProtKB:P27958:PRO_0000037573	Human	PMID:25193851
Molecular Function	GO:0005515	protein binding	LTF	IPI	UniProtKB:P75358	Human	PMID:27616280
Molecular Function	GO:0005515	protein binding	LTF	IPI	UniProtKB:P75390	Human	PMID:27616280
Molecular Function	GO:0005515	protein binding	LTF	IPI	UniProtKB:P75391	Human	PMID:27616280
Molecular Function	GO:0005515	protein binding	LTF	IPI	UniProtKB:P75392	Human	PMID:27616280
Molecular Function	GO:0005515	protein binding	LTF	IPI	UniProtKB:P78031	Human	PMID:27616280
Molecular Function	GO:0005515	protein binding	LTF	IPI	UniProtKB:P27958:PRO_0000037569	Human	PMID:9223490
Molecular Function	GO:0005515	protein binding	LTF	IPI	UniProtKB:P27958:PRO_0000037570	Human	PMID:9223490
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	LTF	IDA		Human	PMID:20345905
Cellular Component	GO:0009986	cell surface	LTF	IDA		Human	PMID:17567961
Cellular Component	GO:0005737	cytoplasm	LTF	IMP		Human	PMID:25193851
Cellular Component	GO:0005737	cytoplasm	Ltf	IDA		Mouse	PMID:17023661
Cellular Component	GO:0070062	extracellular exosome	LTF	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	LTF	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	LTF	IDA		Human	PMID:12788072
Cellular Component	GO:0005615	extracellular space	LTF	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	LTF	IDA		Human	PMID:17567961
Cellular Component	GO:0005615	extracellular space	LTF	IDA		Human	PMID:18714013
Cellular Component	GO:0005615	extracellular space	LTF	HDA		Human	PMID:22664934
Cellular Component	GO:0005615	extracellular space	LTF	HDA		Human	PMID:23580065
Cellular Component	GO:0005634	nucleus	LTF	HDA		Human	PMID:21630459
Cellular Component	GO:0032991	protein-containing complex	LTF	IDA		Human	PMID:17567961
Cellular Component	GO:0030141	secretory granule	LTF	IDA		Human	PMID:11907569
Cellular Component	GO:0042581	specific granule	LTF	IDA		Human	PMID:2981589
Biological Process	GO:0019731	antibacterial humoral response	LTF	IDA		Human	PMID:1599934
Biological Process	GO:0019731	antibacterial humoral response	LTF	IDA		Human	PMID:18714013
Biological Process	GO:0019732	antifungal humoral response	LTF	IDA		Human	PMID:11083624
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	LTF	IMP		Human	PMID:15155221
Biological Process	GO:0060349	bone morphogenesis	LTF	IDA		Human	PMID:15166119
Biological Process	GO:0050829	defense response to Gram-negative bacterium	LTF	IMP		Human	PMID:15155221
Biological Process	GO:0052337	disruption by host of symbiont membrane	LTF	IMP		Human	PMID:15155221
Biological Process	GO:0042541	hemoglobin biosynthetic process	tfa	IMP	ZFIN:ZDB-MRPHLNO-090609-8	Zfish	PMID:19047682
Biological Process	GO:0042541	hemoglobin biosynthetic process	tfa	IMP	ZFIN:ZDB-MRPHLNO-090609-8,ZFIN:ZDB-MRPHLNO-090609-9	Zfish	PMID:19047682
Biological Process	GO:0042541	hemoglobin biosynthetic process	tfa	IMP	ZFIN:ZDB-MRPHLNO-090609-9	Zfish	PMID:19047682
Biological Process	GO:0002227	innate immune response in mucosa	LTF	IDA		Human	PMID:12037568
Biological Process	GO:0006826	iron ion transport	tfa	IMP	ZFIN:ZDB-MRPHLNO-090609-8	Zfish	PMID:19047682
Biological Process	GO:0031640	killing of cells of another organism	LTF	IMP		Human	PMID:15155221
Biological Process	GO:0031640	killing of cells of another organism	LTF	IDA		Human	PMID:9727055
Biological Process	GO:0044793	negative regulation by host of viral process	LTF	IMP		Human	PMID:12522210
Biological Process	GO:0032780	negative regulation of ATP-dependent activity	LTF	IMP		Human	PMID:25193851
Biological Process	GO:2000117	negative regulation of cysteine-type endopeptidase activity	LTF	IDA		Human	PMID:12788072
Biological Process	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	LTF	IDA		Human	PMID:20345905
Biological Process	GO:1900229	negative regulation of single-species biofilm formation in or on host organism	LTF	IDA		Human	PMID:12037568
Biological Process	GO:0045071	negative regulation of viral genome replication	LTF	IMP		Human	PMID:25193851
Biological Process	GO:0048525	negative regulation of viral process	LTF	IMP		Human	PMID:25193851
Biological Process	GO:1902732	positive regulation of chondrocyte proliferation	LTF	IDA		Human	PMID:15166119
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	LTF	IDA		Human	PMID:20345905
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	LTF	IDA		Human	PMID:20345905
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	LTF	IDA		Human	PMID:15166119
Biological Process	GO:0033690	positive regulation of osteoblast proliferation	LTF	IDA		Human	PMID:15166119
Biological Process	GO:0071902	positive regulation of protein serine/threonine kinase activity	LTF	IDA		Human	PMID:20345905
Biological Process	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	LTF	IMP		Human	PMID:20345905
Biological Process	GO:0001817	regulation of cytokine production	LTF	IDA		Human	PMID:20345905
Biological Process	GO:0032680	regulation of tumor necrosis factor production	LTF	IDA		Human	PMID:20345905
Biological Process	GO:0009617	response to bacterium	tfa	IDA		Zfish	PMID:17804254
Biological Process	GO:0001895	retina homeostasis	LTF	HEP		Human	PMID:23580065

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern