Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LTK
  • Mouse genes Ltk
  • Rat genes Ltk
  • Zfish genes ltk
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ltk

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	LTK	IPI	UniProtKB:Q6UXT8	Human	PMID:26418745
Molecular Function	GO:0005515	protein binding	LTK	IPI	UniProtKB:P29317	Human	PMID:35384245
Molecular Function	GO:0004672	protein kinase activity	LTK	IDA		Human	PMID:10445845
Molecular Function	GO:0030298	receptor signaling protein tyrosine kinase activator activity	LTK	IDA		Human	PMID:30061385
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	LTK	IDA		Human	PMID:30061385
Cellular Component	GO:0016020	membrane	LTK	IDA		Human	PMID:10445845
Cellular Component	GO:0016020	membrane	Ltk	IDA		Mouse	PMID:2836739
Cellular Component	GO:0005886	plasma membrane	LTK	IDA		Human	PMID:34646012
Biological Process	GO:0008283	cell population proliferation	LTK	IDA		Human	PMID:10445845
Biological Process	GO:0071300	cellular response to retinoic acid	LTK	IMP		Human	PMID:17910947
Biological Process	GO:0048066	developmental pigmentation	ltk	IMP		Zfish	PMID:18369445|ZFIN:ZDB-PUB-080331-9
Biological Process	GO:0048066	developmental pigmentation	ltk	IGI	ZFIN:ZDB-GENE-030131-5784	Zfish	PMID:19956727
Biological Process	GO:0048066	developmental pigmentation	ltk	IMP	ZFIN:ZDB-GENO-080812-9	Zfish	PMID:19956727
Biological Process	GO:0048066	developmental pigmentation	ltk	IMP	ZFIN:ZDB-GENO-080812-9	Zfish	PMID:23737760
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP		Zfish	PMID:18369445|ZFIN:ZDB-PUB-080331-9
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-120316-52	Zfish	PMID:9007256
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-120316-47	Zfish	PMID:9007256
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-190312-2	Zfish	PMID:29078341
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-120316-48	Zfish	PMID:9007256
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-080812-9	Zfish	PMID:23737760
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-080812-10	Zfish	PMID:9007256
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-120316-51	Zfish	PMID:9007256
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-080812-11	Zfish	PMID:9007256
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-120316-46	Zfish	PMID:9007256
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-120316-50	Zfish	PMID:9007256
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-120316-49	Zfish	PMID:9007256
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-120316-54	Zfish	PMID:9007256
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-080812-9	Zfish	PMID:25535837
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-080812-12	Zfish	PMID:9007256
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-120316-53	Zfish	PMID:9007256
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-080812-9	Zfish	PMID:23821036
Biological Process	GO:0098727	maintenance of cell number	ltk	IMP	ZFIN:ZDB-GENO-160808-2	Zfish	PMID:26801003
Biological Process	GO:0030318	melanocyte differentiation	ltk	IMP	ZFIN:ZDB-GENO-120316-47	Zfish	PMID:24173565
Biological Process	GO:0097324	melanocyte migration	ltk	IMP	ZFIN:ZDB-GENO-120316-47	Zfish	PMID:24173565
Biological Process	GO:0043066	negative regulation of apoptotic process	LTK	IMP		Human	PMID:9223670
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation	LTK	IDA		Human	PMID:30061385
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	LTK	IMP		Human	PMID:9223670
Biological Process	GO:0070285	pigment cell development	ltk	IMP		Zfish	PMID:18369445|ZFIN:ZDB-PUB-080331-9
Biological Process	GO:0070285	pigment cell development	ltk	IMP	ZFIN:ZDB-GENO-160808-1	Zfish	PMID:26801003
Biological Process	GO:0070285	pigment cell development	ltk	IMP	ZFIN:ZDB-GENO-160808-2	Zfish	PMID:26801003
Biological Process	GO:0043473	pigmentation	ltk	IMP	ZFIN:ZDB-GENO-120316-51	Zfish	PMID:9007256
Biological Process	GO:0043473	pigmentation	ltk	IMP	ZFIN:ZDB-GENO-080812-12	Zfish	PMID:9007256
Biological Process	GO:0043473	pigmentation	ltk	IMP	ZFIN:ZDB-GENO-120316-54	Zfish	PMID:9007256
Biological Process	GO:0043473	pigmentation	ltk	IMP	ZFIN:ZDB-GENO-120316-47	Zfish	PMID:9007256
Biological Process	GO:0043473	pigmentation	ltk	IMP	ZFIN:ZDB-GENO-120316-46	Zfish	PMID:9007256
Biological Process	GO:0043473	pigmentation	ltk	IMP	ZFIN:ZDB-GENO-120316-53	Zfish	PMID:9007256
Biological Process	GO:0043473	pigmentation	ltk	IMP	ZFIN:ZDB-GENO-120316-50	Zfish	PMID:9007256
Biological Process	GO:0043473	pigmentation	ltk	IMP	ZFIN:ZDB-GENO-120316-52	Zfish	PMID:9007256
Biological Process	GO:0043473	pigmentation	ltk	IMP	ZFIN:ZDB-GENO-120316-48	Zfish	PMID:9007256
Biological Process	GO:0043473	pigmentation	ltk	IMP	ZFIN:ZDB-GENO-080812-11	Zfish	PMID:9007256
Biological Process	GO:0043473	pigmentation	ltk	IMP	ZFIN:ZDB-GENO-080812-10	Zfish	PMID:9007256
Biological Process	GO:0043473	pigmentation	ltk	IMP	ZFIN:ZDB-GENO-120316-49	Zfish	PMID:9007256
Biological Process	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	LTK	IDA		Human	PMID:10445845
Biological Process	GO:0010976	positive regulation of neuron projection development	LTK	IMP		Human	PMID:17910947
Biological Process	GO:0006468	protein phosphorylation	LTK	IDA		Human	PMID:9223670
Biological Process	GO:0048070	regulation of developmental pigmentation	ltk	IMP		Zfish	PMID:18369445|ZFIN:ZDB-PUB-080331-9
Biological Process	GO:0048070	regulation of developmental pigmentation	ltk	IMP	ZFIN:ZDB-GENO-080812-9	Zfish	PMID:23821036
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	LTK	IDA		Human	PMID:30061385

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern