Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LYVE1
  • Mouse genes Lyve1
  • Rat genes Lyve1
  • Zfish genes lyve1a,lyve1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lyve1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0038024	cargo receptor activity	Lyve1	IDA		Mouse	PMID:11278811
Molecular Function	GO:0005540	hyaluronic acid binding	LYVE1	IDA		Human	PMID:26823460
Molecular Function	GO:0005540	hyaluronic acid binding	Lyve1	IDA		Mouse	PMID:11278811
Molecular Function	GO:0005540	hyaluronic acid binding	lyve1a	IDA		Zfish	ZFIN:ZDB-PUB-141209-19
Molecular Function	GO:0005515	protein binding	LYVE1	IPI	UniProtKB:P60410	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LYVE1	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LYVE1	IPI	UniProtKB:O76011	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LYVE1	IPI	UniProtKB:P0DPK4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LYVE1	IPI	UniProtKB:P51798	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LYVE1	IPI	UniProtKB:P54852	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LYVE1	IPI	UniProtKB:P60328	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LYVE1	IPI	UniProtKB:Q07326	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LYVE1	IPI	UniProtKB:Q3LI66	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LYVE1	IPI	UniProtKB:Q8IZ57	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LYVE1	IPI	UniProtKB:Q8N6R1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LYVE1	IPI	UniProtKB:Q96EC8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LYVE1	IPI	UniProtKB:Q96JW4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LYVE1	IPI	UniProtKB:Q96PS8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LYVE1	IPI	UniProtKB:Q9BRI3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LYVE1	IPI	UniProtKB:Q9BYQ4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LYVE1	IPI	UniProtKB:Q9C0I4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LYVE1	IPI	UniProtKB:Q9NVC3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LYVE1	IPI	UniProtKB:Q9NVV5-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LYVE1	IPI	UniProtKB:Q9NZG7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LYVE1	IPI	UniProtKB:Q9UPZ6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LYVE1	IPI	UniProtKB:Q9Y385	Human	PMID:32296183
Molecular Function	GO:0004888	transmembrane signaling receptor activity	Lyve1	IDA		Mouse	PMID:11278811
Cellular Component	GO:0071944	cell periphery	Lyve1	IDA		Mouse	PMID:16455951
Cellular Component	GO:0070062	extracellular exosome	LYVE1	HDA		Human	PMID:23533145
Cellular Component	GO:0005886	plasma membrane	LYVE1	IDA		Human	PMID:26823460
Cellular Component	GO:0005886	plasma membrane	Lyve1	IDA		Mouse	PMID:11278811
Biological Process	GO:0006027	glycosaminoglycan catabolic process	Lyve1	IDA		Mouse	PMID:11278811
Biological Process	GO:0030214	hyaluronan catabolic process	Lyve1	IDA		Mouse	PMID:11278811
Biological Process	GO:0001946	lymphangiogenesis	lyve1a	IMP	ZFIN:ZDB-MRPHLNO-141222-2	Zfish	ZFIN:ZDB-PUB-141209-19
Biological Process	GO:0002693	positive regulation of cellular extravasation	LYVE1	IDA		Human	PMID:26823460
Biological Process	GO:0006898	receptor-mediated endocytosis	Lyve1	IDA		Mouse	PMID:11278811

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern