Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MACF1
  • Mouse genes Macf1
  • Rat genes Macf1
  • Zfish genes macf1a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Macf1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	MACF1	IDA		Human	PMID:10559237
Molecular Function	GO:0003779	actin binding	Macf1	IDA		Mouse	PMID:14636561
Molecular Function	GO:0051015	actin filament binding	MACF1	IDA		Human	PMID:27693509
Molecular Function	GO:0016887	ATP hydrolysis activity	Macf1	IDA		Mouse	MGI:MGI:3828223|PMID:18854161
Molecular Function	GO:0045296	cadherin binding	MACF1	HDA		Human	PMID:25468996
Molecular Function	GO:0008017	microtubule binding	Macf1	IDA		Mouse	PMID:14636561
Molecular Function	GO:0051011	microtubule minus-end binding	MACF1	IDA		Human	PMID:27693509
Molecular Function	GO:0005515	protein binding	MACF1	IPI	UniProtKB:Q14686	Human	PMID:11443112
Molecular Function	GO:0005515	protein binding	MACF1	IPI	UniProtKB:Q13439	Human	PMID:15265687
Molecular Function	GO:0005515	protein binding	MACF1	IPI	UniProtKB:Q9NRI5	Human	PMID:17043677
Molecular Function	GO:0005515	protein binding	MACF1	IPI	UniProtKB:Q9NRI5-1	Human	PMID:17043677
Molecular Function	GO:0005515	protein binding	MACF1	IPI	UniProtKB:Q9P1Y5	Human	PMID:27693509
Molecular Function	GO:0005515	protein binding	MACF1	IPI	UniProtKB:Q9P1Y5	Human	PMID:27802168
Molecular Function	GO:0005515	protein binding	MACF1	IPI	UniProtKB:Q9NRI5	Human	PMID:31413325
Molecular Function	GO:0005515	protein binding	Macf1	IPI	UniProtKB:P12003	Mouse	MGI:MGI:3828223|PMID:18854161
Molecular Function	GO:0005515	protein binding	Macf1	IPI	UniProtKB:Q61166|UniProtKB:Q80TV8|UniProtKB:Q8BRT1	Mouse	MGI:MGI:3828223|PMID:18854161
Molecular Function	GO:0005515	protein binding	Macf1	IPI	PR:P10126	Mouse	PMID:21689717
Molecular Function	GO:0005515	protein binding	Macf1	IPI	PR:O35625	Mouse	PMID:16815997
Molecular Function	GO:0005515	protein binding	Macf1	IPI	PR:O88572	Mouse	PMID:16815997
Molecular Function	GO:0005515	protein binding	Macf1	IPI	UniProtKB:O70239	Rat	PMID:16815997|RGD:8553932
Molecular Function	GO:0005515	protein binding	Macf1	IPI	UniProtKB:O75581	Rat	PMID:16815997|RGD:8553932
Molecular Function	GO:0003723	RNA binding	MACF1	HDA		Human	PMID:22681889
Cellular Component	GO:0015629	actin cytoskeleton	Macf1	IDA		Mouse	PMID:14636561
Cellular Component	GO:0005938	cell cortex	macf1a	IDA		Zfish	PMID:28880872
Cellular Component	GO:0005737	cytoplasm	MACF1	IDA		Human	PMID:10559237
Cellular Component	GO:0005737	cytoplasm	MACF1	IDA		Human	PMID:15265687
Cellular Component	GO:0005737	cytoplasm	MACF1	IDA		Human	PMID:16076900
Cellular Component	GO:0005737	cytoplasm	Macf1	IDA		Mouse	MGI:MGI:4947903|PMID:21295697
Cellular Component	GO:0005794	Golgi apparatus	MACF1	IDA		Human	PMID:15265687
Cellular Component	GO:0005794	Golgi apparatus	MACF1	IDA		Human	PMID:16076900
Cellular Component	GO:0016020	membrane	Macf1	IDA		Rat	PMID:16815997|RGD:8553932
Cellular Component	GO:0005874	microtubule	MACF1	IDA		Human	PMID:16076900
Cellular Component	GO:0005874	microtubule	Macf1	IDA		Mouse	MGI:MGI:3828223|PMID:18854161
Cellular Component	GO:0005874	microtubule	Macf1	IDA		Mouse	MGI:MGI:4947903|PMID:21295697
Cellular Component	GO:0015630	microtubule cytoskeleton	Macf1	IDA		Mouse	PMID:14636561
Cellular Component	GO:0032019	mitochondrial cloud	macf1a	IDA		Zfish	PMID:28880872
Cellular Component	GO:0005886	plasma membrane	MACF1	IDA		Human	PMID:20937854
Cellular Component	GO:0014069	postsynaptic density	Macf1	IDA		Mouse	PMID:17114649
Cellular Component	GO:0032587	ruffle membrane	MACF1	IDA		Human	PMID:20937854
Biological Process	GO:0009798	axis specification	macf1a	IMP	ZFIN:ZDB-GENO-110705-3	Zfish	PMID:21219859
Biological Process	GO:0007163	establishment or maintenance of cell polarity	Macf1	IMP		Mouse	PMID:14636561
Biological Process	GO:0043001	Golgi to plasma membrane protein transport	MACF1	IDA		Human	PMID:15265687
Biological Process	GO:0001707	mesoderm formation	Macf1	IMP	MGI:MGI:3652899	Mouse	PMID:16815997
Biological Process	GO:0060832	oocyte animal/vegetal axis specification	macf1a	IMP	ZFIN:ZDB-GENO-100914-2	Zfish	PMID:20808893
Biological Process	GO:1903008	organelle disassembly	macf1a	IMP	ZFIN:ZDB-GENO-180720-5	Zfish	PMID:28880872
Biological Process	GO:0045773	positive regulation of axon extension	MACF1	IDA		Human	PMID:22705394
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	Macf1	IMP		Mouse	MGI:MGI:3640889|PMID:16815997
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	Macf1	IMP		Rat	PMID:16815997|RGD:8553932
Biological Process	GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	Macf1	IMP		Mouse	PMID:16815997
Biological Process	GO:0030334	regulation of cell migration	MACF1	IDA		Human	PMID:27693509
Biological Process	GO:0010632	regulation of epithelial cell migration	Macf1	IMP		Mouse	MGI:MGI:4947903|PMID:21295697
Biological Process	GO:0010632	regulation of epithelial cell migration	Macf1	IMP		Mouse	MGI:MGI:3828223|PMID:18854161
Biological Process	GO:0051893	regulation of focal adhesion assembly	MACF1	IDA		Human	PMID:27693509
Biological Process	GO:0051893	regulation of focal adhesion assembly	Macf1	IMP		Mouse	MGI:MGI:3828223|PMID:18854161
Biological Process	GO:0032886	regulation of microtubule-based process	MACF1	IMP		Human	PMID:20937854
Biological Process	GO:0032886	regulation of microtubule-based process	Macf1	IMP		Mouse	MGI:MGI:4947903|PMID:21295697
Biological Process	GO:0150011	regulation of neuron projection arborization	Macf1	IMP		Mouse	MGI:MGI:6316533|PMID:26526844
Biological Process	GO:0016055	Wnt signaling pathway	Macf1	IMP		Mouse	PMID:16815997
Biological Process	GO:0016055	Wnt signaling pathway	Macf1	IGI	MGI:MGI:1861437	Mouse	PMID:16815997
Biological Process	GO:0042060	wound healing	Macf1	IMP		Mouse	MGI:MGI:4947903|PMID:21295697
Biological Process	GO:0042060	wound healing	Macf1	IMP		Mouse	MGI:MGI:3828223|PMID:18854161

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern