Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MACROH2A1
  • Mouse genes Macroh2a1
  • Rat genes Macroh2a1
  • Zfish genes macroh2a1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Macroh2a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0072570	ADP-D-ribose binding	Macroh2a1	IDA		Mouse	MGI:MGI:6863428|PMID:28991266
Molecular Function	GO:0160002	ADP-D-ribose modification-dependent protein binding	Macroh2a1	IDA		Mouse	PMID:28991266
Molecular Function	GO:0003682	chromatin binding	Macroh2a1	IDA		Mouse	PMID:12082075
Molecular Function	GO:0031490	chromatin DNA binding	MACROH2A1	IDA		Human	PMID:19734898
Molecular Function	GO:0031490	chromatin DNA binding	MACROH2A1	IDA		Human	PMID:24071584
Molecular Function	GO:0010385	double-stranded methylated DNA binding	MACROH2A1	IDA		Human	PMID:24071584
Molecular Function	GO:0019899	enzyme binding	MACROH2A1	IPI	UniProtKB:O95271	Human	PMID:26373281
Molecular Function	GO:0031492	nucleosomal DNA binding	MACROH2A1	IDA		Human	PMID:20008927
Molecular Function	GO:0031492	nucleosomal DNA binding	Macroh2a1	IDA		Mouse	MGI:MGI:5619474|PMID:18936163
Molecular Function	GO:1990841	promoter-specific chromatin binding	Macroh2a1	IDA		Mouse	MGI:MGI:5619474|PMID:18936163
Molecular Function	GO:0005515	protein binding	MACROH2A1	IPI	UniProtKB:P46100	Human	PMID:22391447
Molecular Function	GO:0005515	protein binding	MACROH2A1	IPI	UniProtKB:P04626	Human	PMID:22589551
Molecular Function	GO:0005515	protein binding	MACROH2A1	IPI	UniProtKB:A1L162	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MACROH2A1	IPI	UniProtKB:P61244	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	MACROH2A1	IPI	UniProtKB:A1L162	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MACROH2A1	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MACROH2A1	IPI	UniProtKB:P60410	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MACROH2A1	IPI	UniProtKB:Q12899	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MACROH2A1	IPI	UniProtKB:Q12933	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MACROH2A1	IPI	UniProtKB:Q3SXR9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MACROH2A1	IPI	UniProtKB:Q6ZUT1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MACROH2A1	IPI	UniProtKB:Q8N9E0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MACROH2A1	IPI	UniProtKB:Q8N9Q2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MACROH2A1	IPI	UniProtKB:Q969S3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MACROH2A1	IPI	UniProtKB:U3KQK0	Human	PMID:32296183
Molecular Function	GO:0019901	protein kinase binding	MACROH2A1	IPI	UniProtKB:Q99986	Human	PMID:22194607
Molecular Function	GO:0030291	protein serine/threonine kinase inhibitor activity	MACROH2A1	IMP		Human	PMID:22194607
Molecular Function	GO:0000182	rDNA binding	MACROH2A1	IDA		Human	PMID:24071584
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	MACROH2A1	IDA		Human	PMID:23595991
Molecular Function	GO:0030527	structural constituent of chromatin	MACROH2A1	IDA		Human	PMID:21211722
Molecular Function	GO:0000976	transcription cis-regulatory region binding	MACROH2A1	IDA		Human	PMID:19734898
Molecular Function	GO:0000976	transcription cis-regulatory region binding	MACROH2A1	IDA		Human	PMID:20008927
Cellular Component	GO:0001740	Barr body	MACROH2A1	IDA		Human	PMID:11331621
Cellular Component	GO:0001740	Barr body	MACROH2A1	IDA		Human	PMID:18936163
Cellular Component	GO:0000785	chromatin	MACROH2A1	IDA		Human	PMID:19734898
Cellular Component	GO:0000785	chromatin	MACROH2A1	IDA		Human	PMID:22194607
Cellular Component	GO:0000785	chromatin	MACROH2A1	IDA		Human	PMID:24071584
Cellular Component	GO:0000785	chromatin	Macroh2a1	IDA		Rat	PMID:23463008|RGD:9588477
Cellular Component	GO:0000781	chromosome, telomeric region	MACROH2A1	HDA		Human	PMID:19135898
Cellular Component	GO:0000793	condensed chromosome	Macroh2a1	IDA		Mouse	PMID:12082075
Cellular Component	GO:0070062	extracellular exosome	MACROH2A1	HDA		Human	PMID:23533145
Cellular Component	GO:0000228	nuclear chromosome	MACROH2A1	IDA		Human	PMID:18936163
Cellular Component	GO:0005730	nucleolus	MACROH2A1	IDA		Human	PMID:24071584
Cellular Component	GO:0005654	nucleoplasm	MACROH2A1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0000786	nucleosome	Macroh2a1	IDA		Rat	PMID:1529340|RGD:728409
Cellular Component	GO:0005634	nucleus	MACROH2A1	HDA		Human	PMID:21630459
Cellular Component	GO:0005634	nucleus	Macroh2a1	IDA		Mouse	PMID:28991266
Cellular Component	GO:0005634	nucleus	Macroh2a1	IDA		Mouse	PMID:12419249
Cellular Component	GO:0005634	nucleus	Macroh2a1	IDA		Mouse	PMID:25526730
Cellular Component	GO:0005634	nucleus	Macroh2a1	IDA		Rat	PMID:9138085|RGD:9588326
Cellular Component	GO:0005721	pericentric heterochromatin	MACROH2A1	IDA		Human	PMID:19486527
Cellular Component	GO:0090734	site of DNA damage	MACROH2A1	IDA		Human	PMID:21211722
Biological Process	GO:0006281	DNA repair	MACROH2A1	IDA		Human	PMID:21211722
Biological Process	GO:0007549	dosage compensation	MACROH2A1	IDA		Human	PMID:15053874
Biological Process	GO:0040029	epigenetic regulation of gene expression	MACROH2A1	IMP		Human	PMID:20008927
Biological Process	GO:0071169	establishment of protein localization to chromatin	MACROH2A1	IMP		Human	PMID:19734898
Biological Process	GO:1902750	negative regulation of cell cycle G2/M phase transition	MACROH2A1	IMP		Human	PMID:22194607
Biological Process	GO:0045814	negative regulation of gene expression, epigenetic	MACROH2A1	IMP		Human	PMID:19734898
Biological Process	GO:0045814	negative regulation of gene expression, epigenetic	MACROH2A1	IMP		Human	PMID:23595991
Biological Process	GO:0045814	negative regulation of gene expression, epigenetic	MACROH2A1	IMP		Human	PMID:24071584
Biological Process	GO:1904815	negative regulation of protein localization to chromosome, telomeric region	MACROH2A1	IDA		Human	PMID:26373281
Biological Process	GO:0071901	negative regulation of protein serine/threonine kinase activity	MACROH2A1	IMP		Human	PMID:22194607
Biological Process	GO:1902883	negative regulation of response to oxidative stress	Macroh2a1	IMP		Mouse	MGI:MGI:5819339|PMID:23022728
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	MACROH2A1	IMP		Human	PMID:19734898
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Macroh2a1	IGI	MGI:MGI:3037658	Mouse	PMID:25312643
Biological Process	GO:1901837	negative regulation of transcription of nucleolar large rRNA by RNA polymerase I	MACROH2A1	IGI	UniProtKB:Q9P0M6	Human	PMID:24071584
Biological Process	GO:1901837	negative regulation of transcription of nucleolar large rRNA by RNA polymerase I	MACROH2A1	IMP		Human	PMID:24071584
Biological Process	GO:1901837	negative regulation of transcription of nucleolar large rRNA by RNA polymerase I	Macroh2a1	IMP		Mouse	MGI:MGI:5559643|PMID:24071584
Biological Process	GO:1903226	positive regulation of endodermal cell differentiation	MACROH2A1	IMP		Human	PMID:23595991
Biological Process	GO:0045618	positive regulation of keratinocyte differentiation	MACROH2A1	IMP		Human	PMID:23595991
Biological Process	GO:0034184	positive regulation of maintenance of mitotic sister chromatid cohesion	MACROH2A1	IDA		Human	PMID:26373281
Biological Process	GO:1902884	positive regulation of response to oxidative stress	Macroh2a1	IMP		Mouse	MGI:MGI:5819339|PMID:23022728
Biological Process	GO:0019216	regulation of lipid metabolic process	MACROH2A1	IMP		Human	PMID:25526730
Biological Process	GO:1902688	regulation of NAD metabolic process	Macroh2a1	IDA		Mouse	PMID:28991266
Biological Process	GO:0002082	regulation of oxidative phosphorylation	Macroh2a1	IDA		Mouse	PMID:28991266
Biological Process	GO:1902882	regulation of response to oxidative stress	MACROH2A1	IMP		Human	PMID:23022728
Biological Process	GO:1902882	regulation of response to oxidative stress	Macroh2a1	IMP		Mouse	MGI:MGI:5819339|PMID:23022728
Biological Process	GO:0045815	transcription initiation-coupled chromatin remodeling	MACROH2A1	IMP		Human	PMID:25526730

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern