Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MAD2L2
  • Mouse genes Mad2l2
  • Rat genes Mad2l2
  • Zfish genes mad2l2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mad2l2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008432	JUN kinase binding	MAD2L2	IDA		Human	PMID:17296730
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:O14672	Human	PMID:10527948
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:O35674	Human	PMID:10527948
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:P78536	Human	PMID:10527948
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q13443	Human	PMID:10527948
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q13443	Human	PMID:10531379
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q12834	Human	PMID:11459826
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q9UM11	Human	PMID:11459826
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q9UBZ9	Human	PMID:11485998
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q92733	Human	PMID:11717438
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:P19419	Human	PMID:17296730
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q9H869	Human	PMID:17541814
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:P18011	Human	PMID:17719540
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:P30260	Human	PMID:17719540
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q12834	Human	PMID:17719540
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q9UM11	Human	PMID:17719540
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q7Z3K3	Human	PMID:20850016
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q96JM3	Human	PMID:21063390
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:O60673	Human	PMID:22828282
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:A8K8P3-4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:P14373	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:P15884	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q04864	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q13422	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q13554	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q7L273	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q96JM3	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q6ZNX1	Human	PMID:29656893
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q86V20	Human	PMID:29656893
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q96JM3	Human	PMID:29656893
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q86V20	Human	PMID:29789392
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q96JM3	Human	PMID:29789392
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:O15499	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:O75140-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:O75688-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:O76011	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:O96006	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:P15884-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q04864-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q0VD86	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q6MZQ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q86YS3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q8N720	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q8NB15	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q8TBB0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q8WWY6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q96NG5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q9BYV2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q9C029	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q9C0B1-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q9H0C1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q9H1P6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q9NTX9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q9UKT9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:Q9UPG8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAD2L2	IPI	UniProtKB:P50570-2	Human	PMID:32814053
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	MAD2L2	IPI	UniProtKB:Q9NQB0	Human	PMID:19443654
Cellular Component	GO:0005829	cytosol	MAD2L2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	MAD2L2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	MAD2L2	IDA		Human	PMID:17541814
Cellular Component	GO:0005634	nucleus	MAD2L2	IDA		Human	PMID:19443654
Cellular Component	GO:0005819	spindle	MAD2L2	IDA		Human	PMID:21063390
Cellular Component	GO:0016035	zeta DNA polymerase complex	MAD2L2	IPI		Human	PMID:24449906
Cellular Component	GO:0016035	zeta DNA polymerase complex	MAD2L2	IDA		Human	PMID:20164194
Biological Process	GO:0007015	actin filament organization	MAD2L2	IMP		Human	PMID:19443654
Biological Process	GO:0042772	DNA damage response, signal transduction resulting in transcription	MAD2L2	IDA		Human	PMID:17296730
Biological Process	GO:0006302	double-strand break repair	MAD2L2	IGI		Human	PMID:15988022
Biological Process	GO:0042276	error-prone translesion synthesis	MAD2L2	IDA		Human	PMID:24449906
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	MAD2L2	IMP		Human	PMID:19443654
Biological Process	GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin	MAD2L2	IMP		Human	PMID:19443654
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	MAD2L2	IDA		Human	PMID:19443654
Biological Process	GO:2000042	negative regulation of double-strand break repair via homologous recombination	MAD2L2	IDA		Human	PMID:29656893
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition	MAD2L2	IMP		Human	PMID:19443654
Biological Process	GO:0042177	negative regulation of protein catabolic process	MAD2L2	IDA		Human	PMID:11459826
Biological Process	GO:0010944	negative regulation of transcription by competitive promoter binding	MAD2L2	IMP		Human	PMID:19443654
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	MAD2L2	IDA		Human	PMID:19443654
Biological Process	GO:2000678	negative regulation of transcription regulatory region DNA binding	MAD2L2	IMP		Human	PMID:19443654
Biological Process	GO:1904667	negative regulation of ubiquitin protein ligase activity	MAD2L2	IDA		Human	PMID:11459826
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	MAD2L2	IMP		Human	PMID:17296730
Biological Process	GO:2001034	positive regulation of double-strand break repair via nonhomologous end joining	MAD2L2	IDA		Human	PMID:29656893
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	Mad2l2	IMP		Rat	PMID:27488450|RGD:152995505
Biological Process	GO:1901203	positive regulation of extracellular matrix assembly	Mad2l2	IMP		Rat	PMID:27488450|RGD:152995505
Biological Process	GO:0010628	positive regulation of gene expression	Mad2l2	IMP		Rat	PMID:27488450|RGD:152995505
Biological Process	GO:0045830	positive regulation of isotype switching	MAD2L2	IDA		Human	PMID:29656893
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	MAD2L2	IDA		Human	PMID:17296730
Biological Process	GO:0001558	regulation of cell growth	MAD2L2	IGI		Human	PMID:15988022

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern