Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MAP2K2
  • Mouse genes Map2k2
  • Rat genes Map2k2
  • Zfish genes map2k2a,map2k2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Map2k2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	Map2k2	IDA		Rat	PMID:7611406|RGD:2298674
Molecular Function	GO:0004708	MAP kinase kinase activity	MAP2K2	IDA		Human	PMID:8388392
Molecular Function	GO:0004708	MAP kinase kinase activity	Map2k2	IDA		Mouse	PMID:8297798
Molecular Function	GO:0004708	MAP kinase kinase activity	Map2k2	IDA		Rat	PMID:7611406|RGD:2298674
Molecular Function	GO:0004708	MAP kinase kinase activity	Map2k2	IDA		Rat	PMID:8393135|RGD:61657
Molecular Function	GO:0005078	MAP-kinase scaffold activity	MAP2K2	IMP		Human	PMID:29433126
Molecular Function	GO:0060090	molecular adaptor activity	Map2k2	IDA		Mouse	MGI:MGI:5285164|PMID:20179103
Molecular Function	GO:0030165	PDZ domain binding	MAP2K2	IDA		Human	PMID:21615688
Molecular Function	GO:0005515	protein binding	MAP2K2	IPI	UniProtKB:P04049	Human	PMID:11909642
Molecular Function	GO:0005515	protein binding	MAP2K2	IPI	UniProtKB:P10398	Human	PMID:11909642
Molecular Function	GO:0005515	protein binding	MAP2K2	IPI	UniProtKB:Q8IVT5	Human	PMID:11909642
Molecular Function	GO:0005515	protein binding	MAP2K2	IPI	UniProtKB:P15056	Human	PMID:17979178
Molecular Function	GO:0005515	protein binding	MAP2K2	IPI	UniProtKB:Q12959	Human	PMID:21615688
Molecular Function	GO:0005515	protein binding	MAP2K2	IPI	UniProtKB:P04049	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	MAP2K2	IPI	UniProtKB:P10398	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	MAP2K2	IPI	UniProtKB:P04049	Human	PMID:24746704
Molecular Function	GO:0005515	protein binding	MAP2K2	IPI	UniProtKB:P10398	Human	PMID:24746704
Molecular Function	GO:0005515	protein binding	MAP2K2	IPI	UniProtKB:P15056	Human	PMID:24746704
Molecular Function	GO:0005515	protein binding	MAP2K2	IPI	UniProtKB:O95273	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MAP2K2	IPI	UniProtKB:P15056	Human	PMID:25600339
Molecular Function	GO:0005515	protein binding	MAP2K2	IPI	UniProtKB:P10398	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	MAP2K2	IPI	UniProtKB:Q8IVT5	Human	PMID:27086506
Molecular Function	GO:0005515	protein binding	MAP2K2	IPI	UniProtKB:P15056	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	MAP2K2	IPI	UniProtKB:P15056	Human	PMID:29433126
Molecular Function	GO:0005515	protein binding	MAP2K2	IPI	UniProtKB:Q8IVT5	Human	PMID:29433126
Molecular Function	GO:0005515	protein binding	MAP2K2	IPI	UniProtKB:P04049	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	MAP2K2	IPI	UniProtKB:P10398	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	MAP2K2	IPI	UniProtKB:P15056	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	MAP2K2	IPI	UniProtKB:Q8IVT5	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	MAP2K2	IPI	UniProtKB:P00540	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAP2K2	IPI	UniProtKB:P61978-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAP2K2	IPI	UniProtKB:Q96II5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAP2K2	IPI	UniProtKB:P04049	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	MAP2K2	IPI	UniProtKB:P10398	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	MAP2K2	IPI	UniProtKB:P15056	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	MAP2K2	IPI	UniProtKB:Q8IVT5	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	MAP2K2	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Map2k2	IPI	UniProtKB:Q13526	Mouse	MGI:MGI:5285164|PMID:20179103
Molecular Function	GO:0005515	protein binding	Map2k2	IPI	UniProtKB:P85298-4|UniProtKB:Q13526	Mouse	MGI:MGI:5285164|PMID:20179103
Molecular Function	GO:0005515	protein binding	Map2k2	IPI	UniProtKB:Q8CGE9	Mouse	MGI:MGI:5508605|PMID:17380122
Molecular Function	GO:0005515	protein binding	Map2k2	IPI	RGD:1308105	Rat	PMID:16272159|RGD:2298675
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	MAP2K2	IDA		Human	PMID:8388392
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	Map2k2	IDA		Mouse	PMID:8297798
Molecular Function	GO:0097110	scaffold protein binding	MAP2K2	IPI	UniProtKB:Q61097	Human	PMID:10409742
Molecular Function	GO:0097110	scaffold protein binding	MAP2K2	IPI	UniProtKB:Q12959	Human	PMID:21615688
Cellular Component	GO:0005938	cell cortex	Map2k2	IDA		Rat	PMID:16272159|RGD:2298675
Cellular Component	GO:0005911	cell-cell junction	MAP2K2	IDA		Human	PMID:21615688
Cellular Component	GO:0005737	cytoplasm	Map2k2	IDA		Mouse	PMID:23920377
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	MAP2K2	IDA		Human	PMID:21615688
Cellular Component	GO:0005829	cytosol	Map2k2	IDA		Rat	PMID:16272159|RGD:2298675
Cellular Component	GO:0005829	cytosol	Map2k2	IDA		Rat	PMID:9169613|RGD:155791633
Cellular Component	GO:0005829	cytosol	Map2k2	IDA		Rat	PMID:9397988|RGD:150530477
Cellular Component	GO:0005783	endoplasmic reticulum	MAP2K2	IDA		Human	PMID:21615688
Cellular Component	GO:0005794	Golgi apparatus	MAP2K2	IDA		Human	PMID:21615688
Cellular Component	GO:0005874	microtubule	MAP2K2	IDA		Human	PMID:21615688
Cellular Component	GO:0005634	nucleus	Map2k2	IDA		Rat	PMID:9169613|RGD:155791633
Cellular Component	GO:0048471	perinuclear region of cytoplasm	MAP2K2	IDA		Human	PMID:21615688
Cellular Component	GO:0005778	peroxisomal membrane	MAP2K2	HDA		Human	PMID:21525035
Biological Process	GO:0060502	epithelial cell proliferation involved in lung morphogenesis	Map2k2	IGI	MGI:MGI:1346866	Mouse	PMID:25100655
Biological Process	GO:0070371	ERK1 and ERK2 cascade	MAP2K2	IMP		Human	PMID:24375836
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Map2k2	IGI	MGI:MGI:1346866	Mouse	PMID:25100655
Biological Process	GO:0060324	face development	Map2k2	IGI	MGI:MGI:1346866	Mouse	PMID:18952847
Biological Process	GO:0007507	heart development	Map2k2	IGI	MGI:MGI:1346866	Mouse	PMID:18952847
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Map2k2	IMP		Mouse	PMID:21699731
Biological Process	GO:0060425	lung morphogenesis	Map2k2	IGI	MGI:MGI:1346866	Mouse	PMID:25100655
Biological Process	GO:0010629	negative regulation of gene expression	Map2k2	IGI	UniProtKB:Q01986	Rat	PMID:28947594|RGD:13524616
Biological Process	GO:0036289	peptidyl-serine autophosphorylation	MAP2K2	IDA		Human	PMID:8388392
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Map2k2	IDA		Rat	PMID:9169613|RGD:155791633
Biological Process	GO:0050772	positive regulation of axonogenesis	Map2k2	IGI	MGI:MGI:1346866	Mouse	PMID:24733831
Biological Process	GO:0050772	positive regulation of axonogenesis	Map2k2	IGI	MGI:MGI:88190	Mouse	PMID:24733831
Biological Process	GO:2000147	positive regulation of cell motility	Map2k2	IDA		Mouse	MGI:MGI:5285164|PMID:20179103
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	MAP2K2	IMP		Human	PMID:24375836
Biological Process	GO:0010628	positive regulation of gene expression	MAP2K2	IMP		Human	PMID:24375836
Biological Process	GO:0071902	positive regulation of protein serine/threonine kinase activity	MAP2K2	IDA		Human	PMID:8388392
Biological Process	GO:0006468	protein phosphorylation	Map2k2	IGI	MGI:MGI:1346866	Mouse	PMID:19047410
Biological Process	GO:0006468	protein phosphorylation	Map2k2	IDA		Rat	PMID:7611406|RGD:2298674
Biological Process	GO:0006468	protein phosphorylation	Map2k2	IDA		Rat	PMID:8393135|RGD:61657
Biological Process	GO:0048679	regulation of axon regeneration	Map2k2	IGI	MGI:MGI:1346866	Mouse	PMID:24733831
Biological Process	GO:0048679	regulation of axon regeneration	Map2k2	IGI	MGI:MGI:88190	Mouse	PMID:24733831
Biological Process	GO:0002931	response to ischemia	Map2k2	IDA		Rat	PMID:9169613|RGD:155791633
Biological Process	GO:0048538	thymus development	Map2k2	IGI	MGI:MGI:1346866	Mouse	PMID:18952847
Biological Process	GO:0030878	thyroid gland development	Map2k2	IGI	MGI:MGI:1346866	Mouse	PMID:18952847
Biological Process	GO:0060440	trachea formation	Map2k2	IGI	MGI:MGI:1346866	Mouse	PMID:25100655

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern