Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MAP2K4
  • Mouse genes Map2k4
  • Rat genes Map2k4
  • Zfish genes map2k4a,map2k4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Map2k4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008545	JUN kinase kinase activity	Map2k4	IDA		Rat	PMID:17064355|RGD:2298577
Molecular Function	GO:0008545	JUN kinase kinase activity	Map2k4	IDA		Rat	PMID:7768885|RGD:2293351
Molecular Function	GO:0004708	MAP kinase kinase activity	Map2k4	IDA		Rat	PMID:7768885|RGD:2293351
Molecular Function	GO:0060090	molecular adaptor activity	MAP2K4	EXP		Human	PMID:34439869
Molecular Function	GO:0005515	protein binding	MAP2K4	IPI	UniProtKB:P45983	Human	PMID:16533805
Molecular Function	GO:0005515	protein binding	MAP2K4	IPI	UniProtKB:P45983	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	MAP2K4	IPI	UniProtKB:P45983,UniProtKB:Q16539	Human	PMID:34439869
Molecular Function	GO:0005515	protein binding	MAP2K4	IPI	UniProtKB:Q13233	Human	PMID:9808624
Molecular Function	GO:0005515	protein binding	Map2k4	IPI	UniProtKB:Q9ESN9	Mouse	MGI:MGI:1890011|PMID:10523642
Molecular Function	GO:0005515	protein binding	Map2k4	IPI	UniProtKB:P53349|UniProtKB:Q9ESN9-2	Mouse	MGI:MGI:1890011|PMID:10523642
Molecular Function	GO:0005515	protein binding	Map2k4	IPI	UniProtKB:P53349	Mouse	MGI:MGI:3688364|PMID:14500727
Molecular Function	GO:0005515	protein binding	Map2k4	IPI	RGD:1563691	Rat	PMID:16805806|RGD:2293339
Cellular Component	GO:0030424	axon	Map2k4	IDA		Rat	PMID:9714150|RGD:2293331
Cellular Component	GO:0005829	cytosol	Map2k4	IDA		Rat	PMID:16805806|RGD:2293339
Cellular Component	GO:0032839	dendrite cytoplasm	Map2k4	IDA		Rat	PMID:9714150|RGD:2293331
Cellular Component	GO:0005634	nucleus	Map2k4	IDA		Rat	PMID:16805806|RGD:2293339
Cellular Component	GO:0043204	perikaryon	Map2k4	IDA		Rat	PMID:9714150|RGD:2293331
Biological Process	GO:0061049	cell growth involved in cardiac muscle cell development	Map2k4	IMP		Rat	PMID:9769323|RGD:7495831
Biological Process	GO:0071260	cellular response to mechanical stimulus	MAP2K4	IEP		Human	PMID:19593445
Biological Process	GO:0072709	cellular response to sorbitol	Map2k4	IEP		Rat	PMID:20550965|RGD:7243113
Biological Process	GO:0060027	convergent extension involved in gastrulation	map2k4b	IMP	ZFIN:ZDB-MRPHLNO-110314-6	Zfish	PMID:20564202
Biological Process	GO:0060027	convergent extension involved in gastrulation	map2k4b	IMP	ZFIN:ZDB-MRPHLNO-110314-2	Zfish	PMID:20564202
Biological Process	GO:0048263	determination of dorsal identity	map2k4a	IMP	ZFIN:ZDB-MRPHLNO-071126-4	Zfish	PMID:17681137
Biological Process	GO:0007254	JNK cascade	Map2k4	IDA		Rat	PMID:17064355|RGD:2298577
Biological Process	GO:0007254	JNK cascade	map2k4a	IMP		Zfish	PMID:17681137|ZFIN:ZDB-PUB-070813-12
Biological Process	GO:0000165	MAPK cascade	Map2k4	IPI	PR:Q62073	Mouse	PMID:12556533
Biological Process	GO:2000672	negative regulation of motor neuron apoptotic process	Map2k4	IMP	MGI:MGI:3769117	Mouse	PMID:25100604
Biological Process	GO:0043065	positive regulation of apoptotic process	Map2k4	IMP		Rat	PMID:12029621|RGD:2293345
Biological Process	GO:0045740	positive regulation of DNA replication	Map2k4	IMP		Rat	PMID:9487126|RGD:2293350
Biological Process	GO:0046330	positive regulation of JNK cascade	Map2k4	IDA		Rat	PMID:17064355|RGD:2298577
Biological Process	GO:0043507	positive regulation of JUN kinase activity	map2k4a	IMP		Zfish	PMID:17681137|ZFIN:ZDB-PUB-070813-12
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Map2k4	IMP		Rat	PMID:12514131|RGD:2293340
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	Map2k4	IMP		Rat	PMID:10593906|RGD:2304240
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Map2k4	IDA		Rat	PMID:7768885|RGD:2293351
Biological Process	GO:0034393	positive regulation of smooth muscle cell apoptotic process	Map2k4	IDA		Mouse	MGI:MGI:5770039|PMID:24705900
Biological Process	GO:0006468	protein phosphorylation	Map2k4	IDA		Rat	PMID:17064355|RGD:2298577
Biological Process	GO:0006468	protein phosphorylation	Map2k4	IDA		Rat	PMID:7768885|RGD:2293351
Biological Process	GO:0009611	response to wounding	Map2k4	IMP	MGI:MGI:3769117	Mouse	PMID:25100604

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern