Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MAP2K6
  • Mouse genes Map2k6
  • Rat genes Map2k6
  • Zfish genes map2k6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Map2k6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004708	MAP kinase kinase activity	MAP2K6	IDA		Human	PMID:8663074
Molecular Function	GO:0004708	MAP kinase kinase activity	MAP2K6	IDA		Human	PMID:8663524
Molecular Function	GO:0004708	MAP kinase kinase activity	MAP2K6	IDA		Human	PMID:9218798
Molecular Function	GO:0004708	MAP kinase kinase activity	Map2k6	IMP		Mouse	PMID:20551513
Molecular Function	GO:0004708	MAP kinase kinase activity	Map2k6	IDA		Rat	PMID:20550965|RGD:7243113
Molecular Function	GO:0005515	protein binding	MAP2K6	IPI	UniProtKB:Q16539	Human	PMID:11035004
Molecular Function	GO:0005515	protein binding	MAP2K6	IPI	UniProtKB:P19525	Human	PMID:15229216
Molecular Function	GO:0005515	protein binding	MAP2K6	IPI	UniProtKB:Q16539	Human	PMID:17255949
Molecular Function	GO:0005515	protein binding	MAP2K6	IPI	UniProtKB:Q5S007	Human	PMID:20067578
Molecular Function	GO:0005515	protein binding	MAP2K6	IPI	UniProtKB:Q9NRD5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAP2K6	IPI	UniProtKB:Q16539	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	MAP2K6	IPI	UniProtKB:O76024	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAP2K6	IPI	UniProtKB:Q16236	Human	PMID:32911434
Molecular Function	GO:0005515	protein binding	Map2k6	IPI	PR:Q62073	Mouse	PMID:12556533
Molecular Function	GO:0019901	protein kinase binding	MAP2K6	IPI	UniProtKB:Q9UL54	Human	PMID:11279118
Cellular Component	GO:0005829	cytosol	MAP2K6	IDA		Human	PMID:9768359
Cellular Component	GO:0005829	cytosol	MAP2K6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	MAP2K6	IDA		Human	GO_REF:0000052
Biological Process	GO:0006915	apoptotic process	Map2k6	IEP		Rat	PMID:17007737|RGD:1582278
Biological Process	GO:0060348	bone development	Map2k6	IMP	MGI:MGI:3696052	Mouse	PMID:20551513
Biological Process	GO:0060048	cardiac muscle contraction	Map2k6	IMP	MGI:MGI:2385922,MGI:MGI:3581034	Mouse	PMID:11593045
Biological Process	GO:0072709	cellular response to sorbitol	Map2k6	IEP		Rat	PMID:20550965|RGD:7243113
Biological Process	GO:0000165	MAPK cascade	MAP2K6	IDA		Human	PMID:8663074
Biological Process	GO:0000165	MAPK cascade	Map2k6	IMP		Mouse	PMID:20551513
Biological Process	GO:0000165	MAPK cascade	Map2k6	IPI	PR:Q62073	Mouse	PMID:12556533
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	Map2k6	IMP		Mouse	MGI:MGI:6100652|PMID:29021624
Biological Process	GO:0001649	osteoblast differentiation	Map2k6	IMP		Mouse	PMID:20551513
Biological Process	GO:0022602	ovulation cycle process	Map2k6	IEP		Rat	PMID:11328854|RGD:7495835
Biological Process	GO:0043065	positive regulation of apoptotic process	Map2k6	IMP		Rat	PMID:12029621|RGD:2293345
Biological Process	GO:0043406	positive regulation of MAP kinase activity	Map2k6	IDA		Mouse	PMID:14744933
Biological Process	GO:0043410	positive regulation of MAPK cascade	Map2k6	IDA		Mouse	PMID:15767678
Biological Process	GO:0043410	positive regulation of MAPK cascade	Map2k6	IGI	MGI:MGI:1346868	Mouse	PMID:15767678
Biological Process	GO:0043410	positive regulation of MAPK cascade	Map2k6	IGI	MGI:MGI:1918084	Mouse	PMID:15767678
Biological Process	GO:0043410	positive regulation of MAPK cascade	Map2k6	IMP	MGI:MGI:2385922,MGI:MGI:3581034	Mouse	PMID:11593045
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	Map2k6	IMP		Rat	PMID:10593906|RGD:2304240
Biological Process	GO:1900745	positive regulation of p38MAPK cascade	map2k6	IMP		Zfish	PMID:10995439|ZFIN:ZDB-PUB-001017-5
Biological Process	GO:0032308	positive regulation of prostaglandin secretion	Map2k6	IMP		Rat	PMID:12649265|RGD:7495834
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Map2k6	IDA		Rat	PMID:20550965|RGD:7243113
Biological Process	GO:0006468	protein phosphorylation	Map2k6	IDA		Mouse	PMID:14744933
Biological Process	GO:0006468	protein phosphorylation	Map2k6	IDA		Mouse	PMID:12213961
Biological Process	GO:0002931	response to ischemia	Map2k6	IEP		Rat	PMID:20550965|RGD:7243113
Biological Process	GO:0009410	response to xenobiotic stimulus	Map2k6	IEP		Rat	PMID:16755153|RGD:1582279
Biological Process	GO:0051403	stress-activated MAPK cascade	MAP2K6	IDA		Human	PMID:8663524
Biological Process	GO:0051403	stress-activated MAPK cascade	MAP2K6	IDA		Human	PMID:9218798
Biological Process	GO:0031098	stress-activated protein kinase signaling cascade	MAP2K6	IDA		Human	PMID:35857590

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern