Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Map3k1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes MAP3K1
- Mouse genes Map3k1
- Rat genes Map3k1
- Zfish genes map3k1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Map3k1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008092	cytoskeletal protein binding	Map3k1	IDA		Mouse	PMID:25224220
Molecular Function	GO:0008432	JUN kinase binding	Map3k1	IPI	RGD:628847	Rat	PMID:16006144\|RGD:2293486
Molecular Function	GO:0004706	JUN kinase kinase kinase activity	Map3k1	IDA		Mouse	PMID:14967141
Molecular Function	GO:0004706	JUN kinase kinase kinase activity	Map3k1	IDA		Rat	PMID:9110999\|RGD:2293488
Molecular Function	GO:0004708	MAP kinase kinase activity	Map3k1	EXP		Mouse	MGI:MGI:5767077\|PMID:9065412
Molecular Function	GO:0004708	MAP kinase kinase activity	Map3k1	EXP		Mouse	MGI:MGI:5767078\|PMID:9078260
Molecular Function	GO:0004709	MAP kinase kinase kinase activity	Map3k1	IDA		Rat	PMID:7624324\|RGD:1582177
Molecular Function	GO:0004709	MAP kinase kinase kinase activity	Map3k1	IDA		Rat	PMID:9110999\|RGD:2293488
Molecular Function	GO:0051019	mitogen-activated protein kinase binding	Map3k1	IPI	RGD:70500	Rat	PMID:12049732\|RGD:729224
Molecular Function	GO:0031434	mitogen-activated protein kinase kinase binding	Map3k1	IPI	RGD:1560043	Rat	PMID:16006144\|RGD:2293486
Molecular Function	GO:0031434	mitogen-activated protein kinase kinase binding	Map3k1	IPI	RGD:70495	Rat	PMID:16006144\|RGD:2293486
Molecular Function	GO:0031434	mitogen-activated protein kinase kinase binding	Map3k1	IPI	RGD:1550208	Rat	PMID:7624324\|RGD:1582177
Molecular Function	GO:0005515	protein binding	MAP3K1	IPI	UniProtKB:Q12851	Human	PMID:11784851
Molecular Function	GO:0005515	protein binding	MAP3K1	IPI	UniProtKB:P61962	Human	PMID:14743216
Molecular Function	GO:0005515	protein binding	MAP3K1	IPI	UniProtKB:P15056	Human	PMID:16810323
Molecular Function	GO:0005515	protein binding	MAP3K1	IPI	UniProtKB:P15056	Human	PMID:16888650
Molecular Function	GO:0005515	protein binding	MAP3K1	IPI	UniProtKB:O75369	Human	PMID:19270716
Molecular Function	GO:0005515	protein binding	MAP3K1	IPI	UniProtKB:P61962	Human	PMID:20940704
Molecular Function	GO:0005515	protein binding	MAP3K1	IPI	UniProtKB:Q93009	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	MAP3K1	IPI	UniProtKB:P45985	Human	PMID:9808624
Molecular Function	GO:0005515	protein binding	Map3k1	IPI	UniProtKB:P47809	Mouse	MGI:MGI:3688364\|PMID:14500727
Molecular Function	GO:0005515	protein binding	Map3k1	IPI	UniProtKB:P47809\|UniProtKB:Q9ESN9-2	Mouse	MGI:MGI:1890011\|PMID:10523642
Molecular Function	GO:0005515	protein binding	Map3k1	IPI	UniProtKB:Q9ESN9	Mouse	MGI:MGI:1890011\|PMID:10523642
Molecular Function	GO:0005515	protein binding	Map3k1	IPI	UniProtKB:Q8CF89	Mouse	MGI:MGI:5607447\|PMID:25260751
Molecular Function	GO:0005515	protein binding	Map3k1	IPI	UniProtKB:Q14DJ8	Mouse	PMID:17681137
Molecular Function	GO:0005515	protein binding	Map3k1	IPI	PR:O35625	Mouse	PMID:12826667
Molecular Function	GO:0005515	protein binding	Map3k1	IPI	UniProtKB:P61088	Rat	PMID:25260751\|RGD:10047302
Molecular Function	GO:0005515	protein binding	Map3k1	IPI	UniProtKB:Q12933	Rat	PMID:25260751\|RGD:10047302
Molecular Function	GO:0004672	protein kinase activity	MAP3K1	IDA		Human	PMID:15001576
Molecular Function	GO:0019901	protein kinase binding	MAP3K1	IPI	UniProtKB:Q15208	Human	PMID:17906693
Molecular Function	GO:0004674	protein serine/threonine kinase activity	MAP3K1	EXP		Human	PMID:7997270
Molecular Function	GO:0004674	protein serine/threonine kinase activity	MAP3K1	EXP		Human	PMID:9639556
Molecular Function	GO:0044877	protein-containing complex binding	Map3k1	IDA		Rat	PMID:11784851\|RGD:70607
Molecular Function	GO:0046625	sphingolipid binding	Map3k1	IPI	CHEBI:17761	Rat	PMID:15164763\|RGD:2293487
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	Map3k1	IMP		Rat	PMID:12049732\|RGD:729224
Cellular Component	GO:0005737	cytoplasm	Map3k1	IDA		Rat	PMID:16427076\|RGD:2293541
Cellular Component	GO:0005856	cytoskeleton	Map3k1	IDA		Rat	PMID:16427076\|RGD:2293541
Cellular Component	GO:0031941	filamentous actin	Map3k1	IDA		Mouse	PMID:25224220
Cellular Component	GO:0016020	membrane	Map3k1	IDA		Rat	PMID:8643568\|RGD:729395
Biological Process	GO:0008637	apoptotic mitochondrial changes	Map3k1	IMP		Mouse	PMID:15882989
Biological Process	GO:0043010	camera-type eye development	Map3k1	IMP	MGI:MGI:2676654	Mouse	PMID:12941696
Biological Process	GO:0071260	cellular response to mechanical stimulus	MAP3K1	IEP		Human	PMID:19593445
Biological Process	GO:0003382	epithelial cell morphogenesis	Map3k1	IMP	MGI:MGI:2676654	Mouse	PMID:23201579
Biological Process	GO:0061029	eyelid development in camera-type eye	Map3k1	IMP	MGI:MGI:2676654	Mouse	PMID:23201579
Biological Process	GO:0061029	eyelid development in camera-type eye	Map3k1	IMP	MGI:MGI:2676654	Mouse	PMID:25224220
Biological Process	GO:0007254	JNK cascade	Map3k1	IDA		Mouse	PMID:14967141
Biological Process	GO:0000165	MAPK cascade	Map3k1	IDA		Rat	PMID:9110999\|RGD:2293488
Biological Process	GO:0002011	morphogenesis of an epithelial sheet	Map3k1	IMP	MGI:MGI:2676654	Mouse	PMID:25224220
Biological Process	GO:0032232	negative regulation of actin filament bundle assembly	Map3k1	IDA		Rat	PMID:9155015\|RGD:2293527
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Map3k1	IDA		Rat	PMID:7624324\|RGD:1582177
Biological Process	GO:0030838	positive regulation of actin filament polymerization	Map3k1	IMP	MGI:MGI:2676654	Mouse	PMID:12941696
Biological Process	GO:0030838	positive regulation of actin filament polymerization	Map3k1	IMP	MGI:MGI:2676654	Mouse	PMID:25224220
Biological Process	GO:0043065	positive regulation of apoptotic process	Map3k1	IMP		Rat	PMID:17101801\|RGD:2293490
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	Map3k1	IMP		Rat	PMID:20128690\|RGD:150573713
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Map3k1	IMP		Rat	PMID:20128690\|RGD:150573713
Biological Process	GO:0046330	positive regulation of JNK cascade	Map3k1	IDA		Rat	PMID:9110999\|RGD:2293488
Biological Process	GO:0043507	positive regulation of JUN kinase activity	Map3k1	IDA		Mouse	MGI:MGI:1890011\|PMID:10523642
Biological Process	GO:0043507	positive regulation of JUN kinase activity	Map3k1	IDA		Rat	PMID:9110999\|RGD:2293488
Biological Process	GO:0043406	positive regulation of MAP kinase activity	Map3k1	IDA		Rat	PMID:9110999\|RGD:2293488
Biological Process	GO:0043410	positive regulation of MAPK cascade	Map3k1	IDA		Rat	PMID:7624324\|RGD:1582177
Biological Process	GO:0043410	positive regulation of MAPK cascade	Map3k1	IDA		Rat	PMID:9110999\|RGD:2293488
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Map3k1	IDA		Rat	PMID:9155015\|RGD:2293527
Biological Process	GO:0050434	positive regulation of viral transcription	Map3k1	IDA		Rat	PMID:11746500\|RGD:2293493
Biological Process	GO:0046777	protein autophosphorylation	Map3k1	IMP		Rat	PMID:11784851\|RGD:70607
Biological Process	GO:0046777	protein autophosphorylation	Map3k1	IDA		Rat	PMID:12049732\|RGD:729224
Biological Process	GO:0006468	protein phosphorylation	Map3k1	IDA		Rat	PMID:9110999\|RGD:2293488
Biological Process	GO:0000209	protein polyubiquitination	Map3k1	IMP		Rat	PMID:12049732\|RGD:729224
Biological Process	GO:0030334	regulation of cell migration	Map3k1	IMP	MGI:MGI:2676654	Mouse	PMID:12941696
Biological Process	GO:0006970	response to osmotic stress	Map3k1	IMP		Rat	PMID:17101801\|RGD:2293490
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	Map3k1	IMP	MGI:MGI:2676654	Mouse	PMID:12941696
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	Map3k1	IGI	RGD:70500	Rat	PMID:12049732\|RGD:729224
Biological Process	GO:0042060	wound healing	Map3k1	IMP	MGI:MGI:2676654	Mouse	PMID:12941696

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.