Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MAP3K10
  • Mouse genes Map3k10
  • Rat genes Map3k10
  • Zfish genes map3k10
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Map3k10

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043425	bHLH transcription factor binding	MAP3K10	IPI	UniProtKB:P15923	Human	PMID:19801649
Molecular Function	GO:0005515	protein binding	MAP3K10	IPI	UniProtKB:Q5TCX8	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	MAP3K10	IPI	UniProtKB:Q5TCX8	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	Map3k10	IPI	UniProtKB:P61201	Mouse	PMID:15062575
Molecular Function	GO:0005515	protein binding	Map3k10	IPI	UniProtKB:Q498M5	Rat	PMID:22128169|RGD:13673844
Molecular Function	GO:0004672	protein kinase activity	Map3k10	IDA		Mouse	PMID:15062575
Molecular Function	GO:0004674	protein serine/threonine kinase activity	MAP3K10	IDA		Human	PMID:19801649
Molecular Function	GO:0003714	transcription corepressor activity	Map3k10	IDA		Mouse	PMID:15062575
Cellular Component	GO:0005737	cytoplasm	MAP3K10	IDA		Human	PMID:18455992
Biological Process	GO:0008219	cell death	Map3k10	IMP		Rat	PMID:11416147|RGD:2302272
Biological Process	GO:0006351	DNA-templated transcription	Map3k10	IDA		Mouse	MGI:MGI:3028428|PMID:15062575
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	MAP3K10	IMP		Human	PMID:19801649
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	MAP3K10	IMP		Human	PMID:19801649
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Map3k10	IDA		Mouse	PMID:15062575
Biological Process	GO:0018105	peptidyl-serine phosphorylation	MAP3K10	IDA		Human	PMID:19801649
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	MAP3K10	IDA		Human	PMID:19801649
Biological Process	GO:0043065	positive regulation of apoptotic process	Map3k10	IMP		Rat	PMID:15069087|RGD:1359762
Biological Process	GO:0046330	positive regulation of JNK cascade	MAP3K10	IMP		Human	PMID:17584736
Biological Process	GO:0043507	positive regulation of JUN kinase activity	MAP3K10	IMP		Human	PMID:17584736
Biological Process	GO:0006468	protein phosphorylation	Map3k10	IPI	UniProtKB:P61201	Mouse	PMID:15062575
Biological Process	GO:0007224	smoothened signaling pathway	MAP3K10	IMP		Human	PMID:18455992

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern