Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MAP3K12
  • Mouse genes Map3k12
  • Rat genes Map3k12
  • Zfish genes map3k12
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Map3k12

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	MAP3K12	IPI	UniProtKB:Q70Z53	Human	PMID:16169070
Molecular Function	GO:0005515	protein binding	MAP3K12	IPI	UniProtKB:P00533	Human	PMID:20029029
Molecular Function	GO:0005515	protein binding	MAP3K12	IPI	UniProtKB:P00533	Human	PMID:31980649
Molecular Function	GO:0042803	protein homodimerization activity	Map3k12	IDA		Mouse	MGI:MGI:3687417|PMID:8663324
Molecular Function	GO:0019901	protein kinase binding	MAP3K12	IPI	UniProtKB:O14733	Human	PMID:14697235
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	Map3k12	IMP		Mouse	MGI:MGI:5810221|PMID:27511108
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Map3k12	IMP		Mouse	MGI:MGI:5810221|PMID:27511108
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Map3k12	IDA		Mouse	MGI:MGI:3687417|PMID:8663324
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Map3k12	IDA		Mouse	MGI:MGI:69622|PMID:7983011
Cellular Component	GO:0030424	axon	Map3k12	IDA		Mouse	PMID:18031680
Cellular Component	GO:0005829	cytosol	Map3k12	IDA		Mouse	MGI:MGI:3687417|PMID:8663324
Cellular Component	GO:0030426	growth cone	Map3k12	IDA		Mouse	PMID:18031680
Cellular Component	GO:0005886	plasma membrane	Map3k12	IDA		Mouse	MGI:MGI:3687417|PMID:8663324
Biological Process	GO:0007254	JNK cascade	Map3k12	IMP		Mouse	MGI:MGI:5810221|PMID:27511108
Biological Process	GO:2000672	negative regulation of motor neuron apoptotic process	Map3k12	IMP	MGI:MGI:3760641	Mouse	PMID:25100604
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Map3k12	IMP		Mouse	MGI:MGI:5810221|PMID:27511108
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Map3k12	IDA		Mouse	MGI:MGI:69622|PMID:7983011
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	Map3k12	IDA		Mouse	MGI:MGI:69622|PMID:7983011
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	MAP3K12	IMP		Human	PMID:28111074
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	MAP3K12	IMP		Human	PMID:28111074
Biological Process	GO:0043507	positive regulation of JUN kinase activity	Map3k12	IMP		Mouse	MGI:MGI:5810221|PMID:27511108
Biological Process	GO:0045860	positive regulation of protein kinase activity	Map3k12	IMP		Mouse	MGI:MGI:5810221|PMID:27511108
Biological Process	GO:0043687	post-translational protein modification	Map3k12	IDA		Mouse	MGI:MGI:3687417|PMID:8663324
Biological Process	GO:0046777	protein autophosphorylation	Map3k12	IDA		Mouse	MGI:MGI:3687417|PMID:8663324
Biological Process	GO:0046777	protein autophosphorylation	Map3k12	IDA		Mouse	MGI:MGI:69622|PMID:7983011
Biological Process	GO:0006468	protein phosphorylation	MAP3K12	IDA		Human	PMID:14697235

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern