Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MAP3K3
  • Mouse genes Map3k3
  • Rat genes Map3k3
  • Zfish genes map3k3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Map3k3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	MAP3K3	IPI	UniProtKB:P62258	Human	PMID:12392720
Molecular Function	GO:0005515	protein binding	MAP3K3	IPI	UniProtKB:P27348	Human	PMID:14743216
Molecular Function	GO:0005515	protein binding	MAP3K3	IPI	UniProtKB:P31946	Human	PMID:14743216
Molecular Function	GO:0005515	protein binding	MAP3K3	IPI	UniProtKB:P61981	Human	PMID:14743216
Molecular Function	GO:0005515	protein binding	MAP3K3	IPI	UniProtKB:P62258	Human	PMID:14743216
Molecular Function	GO:0005515	protein binding	MAP3K3	IPI	UniProtKB:P63104	Human	PMID:14743216
Molecular Function	GO:0005515	protein binding	MAP3K3	IPI	UniProtKB:Q04917	Human	PMID:14743216
Molecular Function	GO:0005515	protein binding	MAP3K3	IPI	UniProtKB:Q13163	Human	PMID:14743216
Molecular Function	GO:0005515	protein binding	MAP3K3	IPI	UniProtKB:Q6Q0C0	Human	PMID:14743216
Molecular Function	GO:0005515	protein binding	MAP3K3	IPI	UniProtKB:Q6Q0C0	Human	PMID:15001576
Molecular Function	GO:0005515	protein binding	MAP3K3	IPI	UniProtKB:P62258	Human	PMID:16407301
Molecular Function	GO:0005515	protein binding	MAP3K3	IPI	UniProtKB:P31946	Human	PMID:18308725
Molecular Function	GO:0005515	protein binding	MAP3K3	IPI	UniProtKB:Q13163	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	MAP3K3	IPI	UniProtKB:Q9BSQ5-1	Human	PMID:25982527
Molecular Function	GO:0005515	protein binding	MAP3K3	IPI	UniProtKB:Q9BSQ5-1	Human	PMID:27027284
Molecular Function	GO:0005515	protein binding	MAP3K3	IPI	UniProtKB:P27348	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	MAP3K3	IPI	UniProtKB:P61981	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	MAP3K3	IPI	UniProtKB:P63104	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	MAP3K3	IPI	UniProtKB:Q04917	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	MAP3K3	IPI	UniProtKB:P61981	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	MAP3K3	IPI	UniProtKB:Q04917	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	MAP3K3	IPI	UniProtKB:Q13163	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	MAP3K3	IPI	UniProtKB:Q6Q0C0	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	Map3k3	IPI	UniProtKB:P70196	Mouse	MGI:MGI:5508260|PMID:16362041
Molecular Function	GO:0005515	protein binding	Map3k3	IPI	UniProtKB:Q9WVS7	Mouse	MGI:MGI:2675918|PMID:12912994
Molecular Function	GO:0005515	protein binding	Map3k3	IPI	UniProtKB:Q9WVS7	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0005515	protein binding	Map3k3	IPI	UniProtKB:P70196	Mouse	MGI:MGI:3028350|PMID:14661019
Molecular Function	GO:0004672	protein kinase activity	MAP3K3	IDA		Human	PMID:15001576
Biological Process	GO:0009948	anterior/posterior axis specification	map3k3	IGI	ZFIN:ZDB-GENO-160218-8,ZFIN:ZDB-MRPHLNO-160205-1,ZFIN:ZDB-MRPHLNO-160205-3	Zfish	PMID:26540726
Biological Process	GO:0009948	anterior/posterior axis specification	map3k3	IGI	ZFIN:ZDB-MRPHLNO-160205-1,ZFIN:ZDB-MRPHLNO-160205-3	Zfish	PMID:26540726
Biological Process	GO:0001568	blood vessel development	Map3k3	IMP	MGI:MGI:2178133	Mouse	PMID:10700190
Biological Process	GO:0007507	heart development	map3k3	IGI	ZFIN:ZDB-GENO-220727-1,ZFIN:ZDB-MRPHLNO-220309-5	Zfish	PMID:25625206
Biological Process	GO:0007507	heart development	map3k3	IGI	ZFIN:ZDB-MRPHLNO-220309-1,ZFIN:ZDB-MRPHLNO-220309-5	Zfish	PMID:25625206
Biological Process	GO:0007507	heart development	map3k3	IGI	ZFIN:ZDB-GENO-160218-8,ZFIN:ZDB-MRPHLNO-160205-1,ZFIN:ZDB-MRPHLNO-160205-3	Zfish	PMID:26540726
Biological Process	GO:0007507	heart development	map3k3	IGI	ZFIN:ZDB-MRPHLNO-160205-1,ZFIN:ZDB-MRPHLNO-160205-3	Zfish	PMID:26540726
Biological Process	GO:0035556	intracellular signal transduction	MAP3K3	IDA		Human	PMID:15001576
Biological Process	GO:2000773	negative regulation of cellular senescence	MAP3K3	IMP		Human	PMID:28640956
Biological Process	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	MAP3K3	IGI	RNAcentral:URS0000083D87_9606	Human	PMID:28640956
Biological Process	GO:0071864	positive regulation of cell proliferation in bone marrow	MAP3K3	IMP		Human	PMID:28640956
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	MAP3K3	IEP		Human	PMID:12761501
Biological Process	GO:1900745	positive regulation of p38MAPK cascade	Map3k3	IDA		Mouse	PMID:10700190
Biological Process	GO:0046777	protein autophosphorylation	MAP3K3	IDA		Human	PMID:15001576

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern