Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MAP3K5
  • Mouse genes Map3k5
  • Rat genes Map3k5
  • Zfish genes map3k5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Map3k5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	MAP3K5	IDA		Human	PMID:17210579
Molecular Function	GO:0042802	identical protein binding	MAP3K5	IPI	UniProtKB:Q99683	Human	PMID:17937911
Molecular Function	GO:0042802	identical protein binding	MAP3K5	IPI	UniProtKB:Q99683	Human	PMID:19805025
Molecular Function	GO:0042802	identical protein binding	MAP3K5	IPI	UniProtKB:Q99683	Human	PMID:9743501
Molecular Function	GO:0004706	JUN kinase kinase kinase activity	MAP3K5	IDA		Human	PMID:11959862
Molecular Function	GO:0000287	magnesium ion binding	MAP3K5	IDA		Human	PMID:17210579
Molecular Function	GO:0004709	MAP kinase kinase kinase activity	MAP3K5	IDA		Human	PMID:17210579
Molecular Function	GO:0004709	MAP kinase kinase kinase activity	Map3k5	IDA		Mouse	MGI:MGI:3829088|PMID:18948261
Molecular Function	GO:0004709	MAP kinase kinase kinase activity	Map3k5	IDA		Rat	PMID:20550965|RGD:7243113
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:Q9UER7	Human	PMID:11003656
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:P31749	Human	PMID:11154276
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:P03406	Human	PMID:11298454
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:Q9UER7	Human	PMID:11495919
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:P08069	Human	PMID:12556535
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:Q5VWQ8	Human	PMID:12813029
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:Q9D1C8	Human	PMID:14557248
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:Q16890	Human	PMID:14761963
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:P31946	Human	PMID:15023544
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:P63104	Human	PMID:15023544
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:Q04917	Human	PMID:15023544
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:P10599	Human	PMID:15246877
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:Q9UER7	Human	PMID:15983381
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:P63104	Human	PMID:16449798
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:Q12933	Human	PMID:16636664
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:P63098	Human	PMID:16648474
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:Q9WTR2	Human	PMID:17210579
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:Q5VWQ8	Human	PMID:17389591
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:Q04917	Human	PMID:17700517
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:P17302	Human	PMID:17761141
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:Q96HS1	Human	PMID:19590015
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:P32121	Human	PMID:19782076
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:P49407	Human	PMID:19782076
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:P10599	Human	PMID:19805025
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:P46734	Human	PMID:19805025
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:Q12933	Human	PMID:19805025
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:Q99828	Human	PMID:19805025
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:Q16637	Human	PMID:21496457
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:P10599	Human	PMID:21771788
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:P31946	Human	PMID:21771788
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:P46734	Human	PMID:21771788
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:Q969S3	Human	PMID:21771788
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:Q12933	Human	PMID:22095282
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:Q99873	Human	PMID:22095282
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:Q96EZ8	Human	PMID:22609355
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:Q9UER7	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:P63104	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:P62937	Human	PMID:26095851
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:Q04917	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:P46734	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:O43464	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:O60333-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:P02489	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:P04792	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:P20042	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:P28799	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:P41091	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:P50570-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:P54652	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:P60891	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:Q0VDC6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:Q14114-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:Q14204	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:Q8TB36	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:Q92876	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:Q9UBQ0-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAP3K5	IPI	UniProtKB:Q9UER7	Human	PMID:9743501
Molecular Function	GO:0005515	protein binding	Map3k5	IPI	UniProtKB:Q63810	Mouse	MGI:MGI:3625665|PMID:16648474
Molecular Function	GO:0005515	protein binding	Map3k5	IPI	UniProtKB:Q9D1C8	Mouse	MGI:MGI:6294156|PMID:14557248
Molecular Function	GO:0005515	protein binding	Map3k5	IPI	UniProtKB:O09110	Mouse	MGI:MGI:3829088|PMID:18948261
Molecular Function	GO:0005515	protein binding	Map3k5	IPI	PR:Q9ESN9	Mouse	PMID:15767678
Molecular Function	GO:0005515	protein binding	Map3k5	IPI	PR:P63101	Mouse	PMID:19451227
Molecular Function	GO:0005515	protein binding	Map3k5	IPI	PR:Q58A65	Mouse	PMID:15767678
Molecular Function	GO:0005515	protein binding	Map3k5	IPI	PR:Q8CE90	Mouse	PMID:11959862
Molecular Function	GO:0005515	protein binding	Map3k5	IPI	RGD:1310457	Rat	PMID:12050113|RGD:2298760
Molecular Function	GO:0005515	protein binding	Map3k5	IPI	UniProtKB:B5DFH7	Rat	PMID:12050113|RGD:2298760
Molecular Function	GO:0005515	protein binding	Map3k5	IPI	RGD:61998	Rat	PMID:12786973|RGD:2298728
Molecular Function	GO:0005515	protein binding	Map3k5	IPI	RGD:68415	Rat	PMID:12786973|RGD:2298728
Molecular Function	GO:0005515	protein binding	Map3k5	IPI	RGD:621227	Rat	PMID:21843499|RGD:9587791
Molecular Function	GO:0019904	protein domain specific binding	MAP3K5	IPI	UniProtKB:P47897	Human	PMID:11096076
Molecular Function	GO:0042803	protein homodimerization activity	MAP3K5	IDA		Human	PMID:11920685
Molecular Function	GO:0004672	protein kinase activity	MAP3K5	IDA		Human	PMID:11096076
Molecular Function	GO:0004672	protein kinase activity	MAP3K5	IDA		Human	PMID:21771788
Molecular Function	GO:0019901	protein kinase binding	Map3k5	IPI	UniProtKB:Q61846	Mouse	MGI:MGI:3829088|PMID:18948261
Molecular Function	GO:0019903	protein phosphatase binding	MAP3K5	IPI	UniProtKB:Q8K4T5	Human	PMID:11959862
Molecular Function	GO:0019903	protein phosphatase binding	MAP3K5	IPI	UniProtKB:O14830	Human	PMID:20674765
Cellular Component	GO:0005737	cytoplasm	MAP3K5	IDA		Human	PMID:26095851
Cellular Component	GO:0005737	cytoplasm	Map3k5	IDA		Rat	PMID:12786973|RGD:2298728
Cellular Component	GO:0005829	cytosol	Map3k5	IDA		Rat	PMID:20716917|RGD:10412640
Cellular Component	GO:0009897	external side of plasma membrane	Map3k5	IDA		Rat	PMID:12786973|RGD:2298728
Cellular Component	GO:1990604	IRE1-TRAF2-ASK1 complex	MAP3K5	IDA		Human	PMID:12050113
Cellular Component	GO:1990604	IRE1-TRAF2-ASK1 complex	MAP3K5	IDA		Human	PMID:23000344
Cellular Component	GO:1902911	protein kinase complex	MAP3K5	IDA		Human	PMID:15983381
Cellular Component	GO:0032991	protein-containing complex	MAP3K5	IMP		Human	PMID:11096076
Biological Process	GO:0034198	cellular response to amino acid starvation	MAP3K5	IDA		Human	PMID:11096076
Biological Process	GO:0070301	cellular response to hydrogen peroxide	MAP3K5	IDA		Human	PMID:20674765
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Map3k5	IEP		Rat	PMID:16157298|RGD:152025207
Biological Process	GO:1902170	cellular response to reactive nitrogen species	Map3k5	IMP		Mouse	PMID:18007661
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Map3k5	IEP		Rat	PMID:20716917|RGD:10412640
Biological Process	GO:0042742	defense response to bacterium	map3k5	IMP	ZFIN:ZDB-MRPHLNO-191118-1	Zfish	PMID:31314784
Biological Process	GO:0072577	endothelial cell apoptotic process	Map3k5	IEP		Rat	PMID:17932313|RGD:10412644
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Map3k5	IMP		Mouse	MGI:MGI:5616327|PMID:12050113
Biological Process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	MAP3K5	IDA		Human	PMID:21771788
Biological Process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	MAP3K5	IDA		Human	PMID:26095851
Biological Process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	Map3k5	IDA		Mouse	PMID:18948261
Biological Process	GO:0007254	JNK cascade	MAP3K5	IDA		Human	PMID:11959862
Biological Process	GO:0007254	JNK cascade	MAP3K5	IDA		Human	PMID:21771788
Biological Process	GO:0007254	JNK cascade	MAP3K5	IMP		Human	PMID:22095282
Biological Process	GO:0007254	JNK cascade	Map3k5	IDA		Rat	PMID:12524169|RGD:2298708
Biological Process	GO:0000165	MAPK cascade	MAP3K5	IDA		Human	PMID:17210579
Biological Process	GO:0000165	MAPK cascade	MAP3K5	IDA		Human	PMID:21771788
Biological Process	GO:0038066	p38MAPK cascade	Map3k5	IEP		Mouse	MGI:MGI:5320687|PMID:22337877
Biological Process	GO:0043065	positive regulation of apoptotic process	MAP3K5	IDA		Human	PMID:21771788
Biological Process	GO:0043065	positive regulation of apoptotic process	Map3k5	IDA		Mouse	MGI:MGI:3829088|PMID:18948261
Biological Process	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	Map3k5	IMP		Rat	PMID:22635076|RGD:10412335
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	MAP3K5	IDA		Human	PMID:20674765
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	MAP3K5	IDA		Human	PMID:11096076
Biological Process	GO:0046330	positive regulation of JNK cascade	Map3k5	IMP		Mouse	MGI:MGI:5616327|PMID:12050113
Biological Process	GO:0043507	positive regulation of JUN kinase activity	MAP3K5	IMP		Human	PMID:23000344
Biological Process	GO:0043507	positive regulation of JUN kinase activity	Map3k5	IMP		Rat	PMID:20716917|RGD:10412640
Biological Process	GO:0043410	positive regulation of MAPK cascade	Map3k5	IDA		Mouse	PMID:15767678
Biological Process	GO:0045663	positive regulation of myoblast differentiation	Map3k5	IDA		Mouse	MGI:MGI:5320687|PMID:22337877
Biological Process	GO:1901216	positive regulation of neuron death	MAP3K5	IGI	UniProtKB:Q9UER7	Human	PMID:15983381
Biological Process	GO:1901216	positive regulation of neuron death	Map3k5	IMP		Mouse	MGI:MGI:5616327|PMID:12050113
Biological Process	GO:1900745	positive regulation of p38MAPK cascade	Map3k5	IMP		Rat	PMID:20716917|RGD:10412640
Biological Process	GO:0045860	positive regulation of protein kinase activity	MAP3K5	IDA		Human	PMID:11959862
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Map3k5	IDA		Rat	PMID:20550965|RGD:7243113
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	Map3k5	IMP		Rat	PMID:14638553|RGD:10412321
Biological Process	GO:0097300	programmed necrotic cell death	Map3k5	IMP		Mouse	PMID:18007661
Biological Process	GO:0006468	protein phosphorylation	MAP3K5	IDA		Human	PMID:11096076
Biological Process	GO:0006468	protein phosphorylation	MAP3K5	IDA		Human	PMID:15983381
Biological Process	GO:0043067	regulation of programmed cell death	Map3k5	IGI	MGI:MGI:109484	Mouse	PMID:19451227
Biological Process	GO:0034976	response to endoplasmic reticulum stress	MAP3K5	IMP		Human	PMID:23000344
Biological Process	GO:0034976	response to endoplasmic reticulum stress	Map3k5	IMP		Mouse	MGI:MGI:5616327|PMID:12050113
Biological Process	GO:0034976	response to endoplasmic reticulum stress	Map3k5	IEP		Rat	PMID:12050113|RGD:2298760
Biological Process	GO:0002931	response to ischemia	Map3k5	IEP		Rat	PMID:20550965|RGD:7243113
Biological Process	GO:0051403	stress-activated MAPK cascade	MAP3K5	IDA		Human	PMID:11096076
Biological Process	GO:0042060	wound healing	Map3k5	IEP		Rat	PMID:9564892|RGD:10412333

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern