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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Map3k7

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Map3k7
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0005524ATP bindingMap3k7IDARatPMID:16183734|RGD:2298758
Molecular FunctionGO:0140297DNA-binding transcription factor bindingMap3k7IPIRGD:3369RatPMID:28821620|RGD:155804266
Molecular FunctionGO:0035173histone kinase activityMap3k7IDARatPMID:16125722|RGD:155804267
Molecular FunctionGO:0042802identical protein bindingMAP3K7IPIUniProtKB:O43318HumanPMID:27426733
Molecular FunctionGO:1990450linear polyubiquitin bindingMAP3K7IDAHumanPMID:35952808
Molecular FunctionGO:0004707MAP kinase activityMAP3K7IDAHumanPMID:11865055
Molecular FunctionGO:0004708MAP kinase kinase activityMap3k7IDAMousePMID:12464436
Molecular FunctionGO:0004709MAP kinase kinase kinase activityMAP3K7EXPHumanPMID:11460167
Molecular FunctionGO:0004709MAP kinase kinase kinase activityMAP3K7IDAHumanPMID:11460167
Molecular FunctionGO:0004709MAP kinase kinase kinase activityMAP3K7IDAHumanPMID:8663074
Molecular FunctionGO:0004709MAP kinase kinase kinase activityMAP3K7IDAHumanPMID:9079627
Molecular FunctionGO:0004709MAP kinase kinase kinase activityMap3k7IDARatPMID:16183734|RGD:2298758
Molecular FunctionGO:0004709MAP kinase kinase kinase activityMap3k7IDARatPMID:20659889|RGD:155804281
Molecular FunctionGO:0008349MAP kinase kinase kinase kinase activityMap3k7IMPMGI:MGI:3696052MousePMID:20551513
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q9Y4K3HumanPMID:10094049
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q15750HumanPMID:11460167
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q9NYJ8HumanPMID:11460167
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:P45983HumanPMID:11865055
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:P98170HumanPMID:11865055
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q13075HumanPMID:11865055
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q9Y4K3HumanPMID:12496252
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q9HC29HumanPMID:15075345
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:P40763HumanPMID:15764709
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q9UQF2HumanPMID:16840345
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:P0CG48HumanPMID:16845370
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q15750HumanPMID:16845370
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q9NYJ8HumanPMID:16845370
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:O00743HumanPMID:17079228
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:O14733HumanPMID:17110930
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q9NYJ8HumanPMID:17158449
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:O14920HumanPMID:17363973
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q9BYM8HumanPMID:17449468
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:O14733HumanPMID:17709393
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q9UQF2HumanPMID:17709393
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q9UQF2HumanPMID:18286207
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q969V5HumanPMID:18591963
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:P36897HumanPMID:18758450
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:B5Z6S0HumanPMID:19820695
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:P0CG48HumanPMID:19820695
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q9Y4K3HumanPMID:19820695
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q9C035HumanPMID:21512573
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q8N5C8HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q9NYJ8HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q8N5C8HumanPMID:22081109
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q9NYJ8HumanPMID:22081109
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q15750HumanPMID:22158122
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q9NYJ8HumanPMID:22158122
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q9UKE5HumanPMID:22904686
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:O14733HumanPMID:25241761
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q15750HumanPMID:25241761
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q13325HumanPMID:26334375
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q9NYJ8HumanPMID:27426733
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q15750HumanPMID:27880917
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q16543HumanPMID:31980649
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q15750HumanPMID:32707033
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q16543HumanPMID:32707033
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q8N5C8HumanPMID:32707033
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:Q9NYJ8HumanPMID:32707033
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:O14920HumanPMID:33895773
Molecular FunctionGO:0005515protein bindingMAP3K7IPIUniProtKB:P0DTC9HumanPMID:33895773
Molecular FunctionGO:0005515protein bindingMap3k7IPIUniProtKB:Q7TSI1MouseMGI:MGI:5806241|PMID:27777970
Molecular FunctionGO:0005515protein bindingMap3k7IPIUniProtKB:P70340MouseMGI:MGI:3851881|PMID:19536134
Molecular FunctionGO:0005515protein bindingMap3k7IPIUniProtKB:Q60855MouseMGI:MGI:6362574|PMID:31519887
Molecular FunctionGO:0005515protein bindingMap3k7IPIUniProtKB:Q86Y07-1|UniProtKB:Q9WVI9-2MouseMGI:MGI:3843421|PMID:17709393
Molecular FunctionGO:0005515protein bindingMap3k7IPIUniProtKB:Q8CF89|UniProtKB:Q99K90MouseMGI:MGI:5512957|PMID:19026643
Molecular FunctionGO:0005515protein bindingMap3k7IPIUniProtKB:Q99K90MouseMGI:MGI:5553034|PMID:24270572
Molecular FunctionGO:0005515protein bindingMap3k7IPIUniProtKB:Q8N5C8|UniProtKB:Q99K90|UniProtKB:Q9NYJ8MouseMGI:MGI:3708399|PMID:17158449
Molecular FunctionGO:0005515protein bindingMap3k7IPIUniProtKB:Q9DCP9MouseMGI:MGI:6148351|PMID:18762249
Molecular FunctionGO:0005515protein bindingMap3k7IPIUniProtKB:Q9NYJ8MouseMGI:MGI:5917470|PMID:19675569
Molecular FunctionGO:0005515protein bindingMap3k7IPIUniProtKB:P39429MouseMGI:MGI:5300860|PMID:22057290
Molecular FunctionGO:0005515protein bindingMap3k7IPIUniProtKB:Q8CF89MouseMGI:MGI:4839696|PMID:20813258
Molecular FunctionGO:0005515protein bindingMap3k7IPIPR:Q8BHN0MousePMID:12556533
Molecular FunctionGO:0005515protein bindingMap3k7IPIPR:P97433MousePMID:23892723
Molecular FunctionGO:0005515protein bindingMap3k7IPIPR:P70236MousePMID:12556533
Molecular FunctionGO:0005515protein bindingMap3k7IPIRGD:1306216RatPMID:35352799|RGD:155804287
Molecular FunctionGO:0004672protein kinase activityMAP3K7IDAHumanPMID:10094049
Molecular FunctionGO:0004674protein serine/threonine kinase activityMAP3K7EXPHumanPMID:10702308
Molecular FunctionGO:0004674protein serine/threonine kinase activityMAP3K7IDAHumanPMID:10702308
Molecular FunctionGO:0004674protein serine/threonine kinase activityMAP3K7EXPHumanPMID:11460167
Molecular FunctionGO:0004674protein serine/threonine kinase activityMAP3K7EXPHumanPMID:20538596
Molecular FunctionGO:0004674protein serine/threonine kinase activityMap3k7IDAMouseMGI:MGI:6148351|PMID:18762249
Molecular FunctionGO:0120283protein serine/threonine kinase bindingMap3k7IDARatPMID:34733837|RGD:155791674
Molecular FunctionGO:0030971receptor tyrosine kinase bindingMAP3K7IPIUniProtKB:Q01974HumanPMID:18762249
Molecular FunctionGO:0030971receptor tyrosine kinase bindingMap3k7IPIUniProtKB:Q9Z138MouseMGI:MGI:6148351|PMID:18762249
Molecular FunctionGO:0097110scaffold protein bindingMAP3K7IDAHumanPMID:23776175
Molecular FunctionGO:0001223transcription coactivator bindingMap3k7IPIRGD:1585223RatPMID:27956576|RGD:155791649
Molecular FunctionGO:0005114type II transforming growth factor beta receptor bindingMap3k7IPIRGD:69651RatPMID:16360132|RGD:1579925
Molecular FunctionGO:0031625ubiquitin protein ligase bindingMap3k7IPIRGD:1562778RatPMID:30760025|RGD:155804274
Cellular ComponentGO:0140672ATAC complexMAP3K7IDAHumanPMID:18838386
Cellular ComponentGO:0005737cytoplasmMAP3K7IDAHumanPMID:12242293
Cellular ComponentGO:0005829cytosolMAP3K7IDAHumanGO_REF:0000052
Cellular ComponentGO:0005634nucleusMAP3K7HDAHumanPMID:21630459
Cellular ComponentGO:0005886plasma membraneMAP3K7IDAHumanGO_REF:0000052
Cellular ComponentGO:0014069postsynaptic densityMap3k7IDAMousePMID:17114649
Biological ProcessGO:0007250activation of NF-kappaB-inducing kinase activityMAP3K7IMPHumanPMID:10094049
Biological ProcessGO:0007250activation of NF-kappaB-inducing kinase activityMAP3K7IMPHumanPMID:15125833
Biological ProcessGO:0001525angiogenesisMap3k7IMPMGI:MGI:3608889MousePMID:16556914
Biological ProcessGO:0043276anoikisMap3k7IMPMouseMGI:MGI:5819337|PMID:23778976
Biological ProcessGO:0097190apoptotic signaling pathwayMap3k7IGIMGI:MGI:104798MousePMID:16260493
Biological ProcessGO:0097190apoptotic signaling pathwayMap3k7IMPMousePMID:16260493
Biological ProcessGO:0048514blood vessel morphogenesismap3k7IGIZFIN:ZDB-MRPHLNO-060411-2,ZFIN:ZDB-MRPHLNO-060411-3,ZFIN:ZDB-MRPHLNO-060411-4ZfishPMID:16556914
Biological ProcessGO:0060348bone developmentMap3k7IMPMGI:MGI:3696052MousePMID:20551513
Biological ProcessGO:1904385cellular response to angiotensinMap3k7IDARatPMID:20659889|RGD:155804281
Biological ProcessGO:1904385cellular response to angiotensinMap3k7IDARatPMID:27956576|RGD:155791649
Biological ProcessGO:1904385cellular response to angiotensinMap3k7IDARatPMID:34733837|RGD:155791674
Biological ProcessGO:0090650cellular response to oxygen-glucose deprivationMap3k7IEPRatPMID:32734729|RGD:155804275
Biological ProcessGO:0071560cellular response to transforming growth factor beta stimulusMap3k7IDARatPMID:16125722|RGD:155804267
Biological ProcessGO:0071560cellular response to transforming growth factor beta stimulusMap3k7IEPRatPMID:32581266|RGD:155804294
Biological ProcessGO:0071356cellular response to tumor necrosis factorMap3k7IDARatPMID:20659889|RGD:155804281
Biological ProcessGO:0043966histone H3 acetylationMAP3K7IDAHumanPMID:18838386
Biological ProcessGO:0007249I-kappaB kinase/NF-kappaB signalingMAP3K7IDAHumanPMID:19675569
Biological ProcessGO:0007249I-kappaB kinase/NF-kappaB signalingMAP3K7IDAHumanPMID:34871740
Biological ProcessGO:0007249I-kappaB kinase/NF-kappaB signalingMAP3K7IDAHumanPMID:35952808
Biological ProcessGO:0007249I-kappaB kinase/NF-kappaB signalingMap3k7IGIMGI:MGI:2156367MousePMID:16260493
Biological ProcessGO:0007249I-kappaB kinase/NF-kappaB signalingMap3k7IGIMGI:MGI:104798MousePMID:16260493
Biological ProcessGO:0007249I-kappaB kinase/NF-kappaB signalingMap3k7IGIMGI:MGI:96536MousePMID:16260493
Biological ProcessGO:0007252I-kappaB phosphorylationMAP3K7IDAHumanPMID:11460167
Biological ProcessGO:0007252I-kappaB phosphorylationMap3k7IGIMGI:MGI:104798MousePMID:16260493
Biological ProcessGO:0007252I-kappaB phosphorylationMap3k7IGIMGI:MGI:96536MousePMID:16260493
Biological ProcessGO:0038173interleukin-17A-mediated signaling pathwayMAP3K7IDAHumanPMID:31376257
Biological ProcessGO:0007254JNK cascadeMAP3K7IDAHumanPMID:9079627
Biological ProcessGO:0007254JNK cascadeMap3k7IDAMouseMGI:MGI:6162308|PMID:29291351
Biological ProcessGO:0007254JNK cascadeMap3k7IGIMGI:MGI:96536MousePMID:16260493
Biological ProcessGO:0007254JNK cascadeMap3k7IGIMGI:MGI:104798MousePMID:16260493
Biological ProcessGO:0007254JNK cascadeMap3k7IGIMGI:MGI:96824MousePMID:16260493
Biological ProcessGO:0000165MAPK cascadeMAP3K7IDAHumanPMID:11865055
Biological ProcessGO:0000165MAPK cascadeMAP3K7IDAHumanPMID:8663074
Biological ProcessGO:0000165MAPK cascadeMap3k7IMPMousePMID:20551513
Biological ProcessGO:0000165MAPK cascadeMap3k7IDAMousePMID:12556533
Biological ProcessGO:0000165MAPK cascadeMap3k7IDARatPMID:16183734|RGD:2298758
Biological ProcessGO:2001234negative regulation of apoptotic signaling pathwayMap3k7IGIMGI:MGI:104798MousePMID:16260493
Biological ProcessGO:2001234negative regulation of apoptotic signaling pathwayMap3k7IMPMousePMID:16260493
Biological ProcessGO:0010629negative regulation of gene expressionMap3k7IMPRatPMID:26002466|RGD:155804277
Biological ProcessGO:0060546negative regulation of necroptotic processMap3k7IMPMouseMGI:MGI:5315337|PMID:21052097
Biological ProcessGO:2000378negative regulation of reactive oxygen species metabolic processMap3k7IMPMouseMGI:MGI:5315337|PMID:21052097
Biological ProcessGO:1902443negative regulation of ripoptosome assembly involved in necroptotic processMap3k7IGIMGI:MGI:104798MousePMID:21052097
Biological ProcessGO:1902443negative regulation of ripoptosome assembly involved in necroptotic processMap3k7IGIMGI:MGI:108212MousePMID:21052097
Biological ProcessGO:1901386negative regulation of voltage-gated calcium channel activityMap3k7IMPRatPMID:26584289|RGD:155804278
Biological ProcessGO:0001841neural tube formationMap3k7IMPMousePMID:16260493
Biological ProcessGO:0001649osteoblast differentiationMap3k7IMPMGI:MGI:3696052MousePMID:20551513
Biological ProcessGO:0018107peptidyl-threonine phosphorylationMap3k7IDAMouseMGI:MGI:6148351|PMID:18762249
Biological ProcessGO:0010508positive regulation of autophagyMap3k7IMPRatPMID:35078016|RGD:155804282
Biological ProcessGO:0045787positive regulation of cell cycleMap3k7IMPRatPMID:35078016|RGD:155804282
Biological ProcessGO:0045793positive regulation of cell sizeMap3k7IMPRatPMID:32971071|RGD:155791643
Biological ProcessGO:0045793positive regulation of cell sizeMap3k7IMPRatPMID:34733837|RGD:155791674
Biological ProcessGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingMAP3K7IMPHumanPMID:14982987
Biological ProcessGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingMap3k7IGIMGI:MGI:96536MousePMID:16260493
Biological ProcessGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingMap3k7IGIMGI:MGI:104798MousePMID:16260493
Biological ProcessGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingMap3k7IGIMGI:MGI:2156367MousePMID:16260493
Biological ProcessGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingMap3k7IMPRatPMID:17947700|RGD:5508194
Biological ProcessGO:0032743positive regulation of interleukin-2 productionMAP3K7IMPHumanPMID:15125833
Biological ProcessGO:0046330positive regulation of JNK cascadeMap3k7IGIMGI:MGI:96536MousePMID:16260493
Biological ProcessGO:0046330positive regulation of JNK cascadeMap3k7IGIMGI:MGI:96824MousePMID:16260493
Biological ProcessGO:0046330positive regulation of JNK cascadeMap3k7IGIMGI:MGI:104798MousePMID:16260493
Biological ProcessGO:0043507positive regulation of JUN kinase activityMAP3K7IMPHumanPMID:10094049
Biological ProcessGO:0043507positive regulation of JUN kinase activityMAP3K7IDAHumanPMID:11460167
Biological ProcessGO:0016239positive regulation of macroautophagyMap3k7IMPMouseMGI:MGI:5819337|PMID:23778976
Biological ProcessGO:0043410positive regulation of MAPK cascadeMap3k7IDARatPMID:16183734|RGD:2298758
Biological ProcessGO:0002726positive regulation of T cell cytokine productionMAP3K7IMPHumanPMID:15125833
Biological ProcessGO:1904754positive regulation of vascular associated smooth muscle cell migrationMap3k7IMPRatPMID:35078016|RGD:155804282
Biological ProcessGO:1904707positive regulation of vascular associated smooth muscle cell proliferationMap3k7IMPRatPMID:35078016|RGD:155804282
Biological ProcessGO:0036211protein modification processMap3k7IMPRatPMID:20659889|RGD:155804281
Biological ProcessGO:0006468protein phosphorylationMap3k7IDAMouseMGI:MGI:5926457|PMID:28842570
Biological ProcessGO:0006468protein phosphorylationMap3k7IDAMousePMID:12464436
Biological ProcessGO:0006468protein phosphorylationMap3k7IDARatPMID:16125722|RGD:155804267
Biological ProcessGO:0006468protein phosphorylationMap3k7IDARatPMID:16183734|RGD:2298758
Biological ProcessGO:0010468regulation of gene expressionMap3k7IMPRatPMID:34733837|RGD:155791674
Biological ProcessGO:2000377regulation of reactive oxygen species metabolic processMap3k7IMPMousePMID:21052097
Biological ProcessGO:1990776response to angiotensinMap3k7IEPRatPMID:30854566|RGD:155791647
Biological ProcessGO:0001666response to hypoxiaMap3k7IEPRatPMID:22388934|RGD:155791648
Biological ProcessGO:0051403stress-activated MAPK cascadeMAP3K7IDAHumanPMID:9079627
Biological ProcessGO:0007179transforming growth factor beta receptor signaling pathwayMap3k7IMPMousePMID:16145668

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory