Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MAP4K1
  • Mouse genes Map4k1
  • Rat genes Map4k1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Map4k1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	MAP4K1	IDA		Human	PMID:8824585
Molecular Function	GO:0005524	ATP binding	Map4k1	IDA		Mouse	MGI:MGI:84934|PMID:9003777
Molecular Function	GO:0008349	MAP kinase kinase kinase kinase activity	MAP4K1	IDA		Human	PMID:11053428
Molecular Function	GO:0005515	protein binding	MAP4K1	IPI	UniProtKB:P00519	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	MAP4K1	IPI	UniProtKB:P06241	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	MAP4K1	IPI	UniProtKB:P16333	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	MAP4K1	IPI	UniProtKB:P19174	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	MAP4K1	IPI	UniProtKB:P27986	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	MAP4K1	IPI	UniProtKB:P46108	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	MAP4K1	IPI	UniProtKB:P62993	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	MAP4K1	IPI	UniProtKB:Q13291	Human	PMID:20231852
Molecular Function	GO:0005515	protein binding	MAP4K1	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	MAP4K1	IPI	UniProtKB:Q8N3Y1	Human	PMID:24362026
Molecular Function	GO:0005515	protein binding	MAP4K1	IPI	UniProtKB:P08238	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	MAP4K1	IPI	UniProtKB:P08238	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	MAP4K1	IPI	UniProtKB:P62993	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	MAP4K1	IPI	UniProtKB:P46108	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	MAP4K1	IPI	UniProtKB:P00519	Human	PMID:9346925
Molecular Function	GO:0005515	protein binding	MAP4K1	IPI	UniProtKB:P16333	Human	PMID:9346925
Molecular Function	GO:0005515	protein binding	MAP4K1	IPI	UniProtKB:P62993	Human	PMID:9346925
Molecular Function	GO:0005515	protein binding	MAP4K1	IPI	UniProtKB:P46108	Human	PMID:9788432
Molecular Function	GO:0005515	protein binding	MAP4K1	IPI	UniProtKB:P46109	Human	PMID:9788432
Molecular Function	GO:0005515	protein binding	Map4k1	IPI	UniProtKB:Q9BXL7	Mouse	MGI:MGI:6092704|PMID:19706536
Molecular Function	GO:0005515	protein binding	Map4k1	IPI	UniProtKB:Q16584	Mouse	MGI:MGI:84934|PMID:9003777
Molecular Function	GO:0005515	protein binding	Map4k1	IPI	PR:O89100	Mouse	PMID:15100220
Molecular Function	GO:0004674	protein serine/threonine kinase activity	MAP4K1	IDA		Human	PMID:8824585
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Map4k1	IDA		Mouse	MGI:MGI:84934|PMID:9003777
Cellular Component	GO:0016020	membrane	MAP4K1	HDA		Human	PMID:19946888
Biological Process	GO:0008283	cell population proliferation	MAP4K1	IMP		Human	PMID:24362026
Biological Process	GO:1904628	cellular response to phorbol 13-acetate 12-myristate	MAP4K1	IDA		Human	PMID:8824585
Biological Process	GO:0035556	intracellular signal transduction	Map4k1	IDA		Mouse	MGI:MGI:84934|PMID:9003777
Biological Process	GO:0007254	JNK cascade	MAP4K1	IDA		Human	PMID:8824585
Biological Process	GO:0018105	peptidyl-serine phosphorylation	MAP4K1	IDA		Human	PMID:11053428
Biological Process	GO:0018105	peptidyl-serine phosphorylation	MAP4K1	IDA		Human	PMID:24362026
Biological Process	GO:0043410	positive regulation of MAPK cascade	MAP4K1	IDA		Human	PMID:11053428
Biological Process	GO:0046777	protein autophosphorylation	MAP4K1	IDA		Human	PMID:24362026
Biological Process	GO:0046777	protein autophosphorylation	MAP4K1	IDA		Human	PMID:8824585
Biological Process	GO:0006468	protein phosphorylation	MAP4K1	IDA		Human	PMID:8824585
Biological Process	GO:0006468	protein phosphorylation	Map4k1	IDA		Mouse	MGI:MGI:84934|PMID:9003777

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern