Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MAPK6
  • Mouse genes Mapk6
  • Rat genes Mapk6
  • Zfish genes mapk6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mapk6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004707	MAP kinase activity	Mapk6	IDA		Mouse	MGI:MGI:5306310|PMID:15577943
Molecular Function	GO:0005515	protein binding	MAPK6	IPI	UniProtKB:Q8IW41	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	MAPK6	IPI	UniProtKB:Q8IW41	Human	PMID:21900206
Molecular Function	GO:0005515	protein binding	MAPK6	IPI	UniProtKB:Q9H6Z9	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	MAPK6	IPI	UniProtKB:P12504	Human	PMID:22190034
Molecular Function	GO:0005515	protein binding	MAPK6	IPI	UniProtKB:Q8IW41	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	MAPK6	IPI	UniProtKB:Q8IW41	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MAPK6	IPI	UniProtKB:Q8IW41	Human	PMID:26972000
Molecular Function	GO:0005515	protein binding	MAPK6	IPI	UniProtKB:Q9H6Z9	Human	PMID:26972000
Molecular Function	GO:0005515	protein binding	MAPK6	IPI	UniProtKB:Q8IW41-2	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	MAPK6	IPI	UniProtKB:Q8IW41-2	Human	PMID:29426014
Molecular Function	GO:0005515	protein binding	MAPK6	IPI	UniProtKB:Q8IW41-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAPK6	IPI	UniProtKB:Q9GZV1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAPK6	IPI	UniProtKB:Q8IW41	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	Mapk6	IPI	PR:O54992	Mouse	PMID:22508986
Molecular Function	GO:0005515	protein binding	Mapk6	IPI	PR:O54992	Mouse	PMID:15538386
Molecular Function	GO:0005515	protein binding	Mapk6	IPI	PR:O55131	Mouse	PMID:22508986
Molecular Function	GO:0046982	protein heterodimerization activity	Mapk6	IPI	UniProtKB:Q6P5G0	Mouse	MGI:MGI:5306302|PMID:16973613
Molecular Function	GO:0004672	protein kinase activity	Mapk6	IDA		Mouse	PMID:22508986
Molecular Function	GO:0019901	protein kinase binding	Mapk6	IPI	UniProtKB:O54992	Mouse	MGI:MGI:5306310|PMID:15577943
Cellular Component	GO:0005737	cytoplasm	Mapk6	IDA		Mouse	MGI:MGI:5306310|PMID:15577943
Cellular Component	GO:0005737	cytoplasm	Mapk6	IDA		Mouse	PMID:15538386
Cellular Component	GO:0005829	cytosol	MAPK6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Mapk6	IDA		Mouse	MGI:MGI:5306310|PMID:15577943
Cellular Component	GO:0032991	protein-containing complex	Mapk6	IDA		Mouse	PMID:22508986
Cellular Component	GO:0032156	septin cytoskeleton	Mapk6	IDA		Mouse	PMID:22508986
Biological Process	GO:0060999	positive regulation of dendritic spine development	Mapk6	IGI	MGI:MGI:1333110	Mouse	PMID:22508986
Biological Process	GO:0006468	protein phosphorylation	Mapk6	IDA		Mouse	MGI:MGI:5306310|PMID:15577943

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern