Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MAPK7
  • Mouse genes Mapk7
  • Rat genes Mapk7
  • Zfish genes mapk7
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mapk7

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	Mapk7	IDA		Rat	PMID:11782488|RGD:2298794
Molecular Function	GO:0005524	ATP binding	Mapk7	IDA		Rat	PMID:8663194|RGD:2298793
Molecular Function	GO:0004707	MAP kinase activity	Mapk7	IDA		Rat	PMID:11782488|RGD:2298794
Molecular Function	GO:0004707	MAP kinase activity	Mapk7	IDA		Rat	PMID:8663194|RGD:2298793
Molecular Function	GO:0051019	mitogen-activated protein kinase binding	MAPK7	IPI	UniProtKB:Q16236	Human	PMID:23043106
Molecular Function	GO:0005515	protein binding	MAPK7	IPI	UniProtKB:Q13163	Human	PMID:18588859
Molecular Function	GO:0005515	protein binding	MAPK7	IPI	UniProtKB:P29590	Human	PMID:20832753
Molecular Function	GO:0005515	protein binding	MAPK7	IPI	UniProtKB:P29590	Human	PMID:22869143
Molecular Function	GO:0005515	protein binding	MAPK7	IPI	UniProtKB:P08238|UniProtKB:Q16543	Human	PMID:23428871
Molecular Function	GO:0005515	protein binding	MAPK7	IPI	UniProtKB:Q5TZN3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MAPK7	IPI	UniProtKB:Q02078-6	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	MAPK7	IPI	UniProtKB:Q13163	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	MAPK7	IPI	UniProtKB:O95816	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	MAPK7	IPI	UniProtKB:O00762	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAPK7	IPI	UniProtKB:P17029	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAPK7	IPI	UniProtKB:Q13163	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAPK7	IPI	UniProtKB:Q16204	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAPK7	IPI	UniProtKB:Q13163	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	MAPK7	IPI	UniProtKB:Q13163	Human	PMID:7759517
Molecular Function	GO:0005515	protein binding	Mapk7	IPI	UniProtKB:Q8CFN5	Mouse	MGI:MGI:5284808|PMID:14515274
Molecular Function	GO:0005515	protein binding	Mapk7	IPI	UniProtKB:P11499|UniProtKB:Q61081	Mouse	MGI:MGI:5525979|PMID:23428871
Molecular Function	GO:0005515	protein binding	Mapk7	IPI	UniProtKB:A0A096MJY4	Rat	PMID:19103177|RGD:8554846
Molecular Function	GO:0005515	protein binding	Mapk7	IPI	UniProtKB:P34058|UniProtKB:Q63692	Rat	PMID:23428871|RGD:12790637
Molecular Function	GO:0004672	protein kinase activity	Mapk7	IDA		Mouse	MGI:MGI:5284808|PMID:14515274
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Mapk7	IDA		Mouse	PMID:18347059
Cellular Component	GO:0005737	cytoplasm	MAPK7	IDA		Human	PMID:22869143
Cellular Component	GO:0005829	cytosol	MAPK7	IDA		Human	PMID:23043106
Cellular Component	GO:0005829	cytosol	Mapk7	IDA		Mouse	PMID:18347059
Cellular Component	GO:0005654	nucleoplasm	MAPK7	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	MAPK7	IDA		Human	PMID:18588859
Cellular Component	GO:0005634	nucleus	MAPK7	IDA		Human	PMID:22869143
Cellular Component	GO:0005634	nucleus	MAPK7	IDA		Human	PMID:23043106
Cellular Component	GO:0005634	nucleus	Mapk7	IDA		Mouse	PMID:18347059
Cellular Component	GO:0005634	nucleus	Mapk7	IDA		Rat	PMID:11782488|RGD:2298794
Cellular Component	GO:0005634	nucleus	Mapk7	IDA		Rat	PMID:15075238|RGD:1582267
Cellular Component	GO:0016605	PML body	MAPK7	IDA		Human	PMID:22869143
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	Mapk7	IMP		Mouse	PMID:18347059
Biological Process	GO:0071363	cellular response to growth factor stimulus	MAPK7	IGI	UniProtKB:Q62862	Human	PMID:20551324
Biological Process	GO:0070301	cellular response to hydrogen peroxide	MAPK7	IMP		Human	PMID:23043106
Biological Process	GO:0071499	cellular response to laminar fluid shear stress	MAPK7	IMP		Human	PMID:23043106
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	MAPK7	IDA		Human	PMID:18588859
Biological Process	GO:0070375	ERK5 cascade	Mapk7	IMP		Rat	PMID:11782488|RGD:2298794
Biological Process	GO:0000165	MAPK cascade	Mapk7	IMP		Rat	PMID:11782488|RGD:2298794
Biological Process	GO:0043066	negative regulation of apoptotic process	Mapk7	IDA		Mouse	PMID:14675480
Biological Process	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	Mapk7	IMP		Mouse	PMID:18347059
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	MAPK7	IMP		Human	PMID:23043106
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	MAPK7	IGI	UniProtKB:Q62862	Human	PMID:20551324
Biological Process	GO:0034115	negative regulation of heterotypic cell-cell adhesion	MAPK7	IGI	UniProtKB:Q62862	Human	PMID:20551324
Biological Process	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	MAPK7	IMP		Human	PMID:23043106
Biological Process	GO:0060761	negative regulation of response to cytokine stimulus	MAPK7	IGI	UniProtKB:Q62862	Human	PMID:20551324
Biological Process	GO:0001503	ossification	mapk7	IGI	ZFIN:ZDB-GENE-070209-74,ZFIN:ZDB-MRPHLNO-181127-1	Zfish	PMID:30032135
Biological Process	GO:0001503	ossification	mapk7	IMP	ZFIN:ZDB-MRPHLNO-181127-1	Zfish	PMID:30032135
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Mapk7	IDA		Mouse	PMID:18347059
Biological Process	GO:0051247	positive regulation of protein metabolic process	MAPK7	IGI	UniProtKB:Q62862	Human	PMID:20551324
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	MAPK7	IGI	UniProtKB:Q62862	Human	PMID:20551324
Biological Process	GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress	MAPK7	IMP		Human	PMID:23043106
Biological Process	GO:0046777	protein autophosphorylation	Mapk7	IDA		Rat	PMID:11782488|RGD:2298794
Biological Process	GO:0006468	protein phosphorylation	Mapk7	IDA		Mouse	MGI:MGI:5284808|PMID:14515274
Biological Process	GO:0006468	protein phosphorylation	Mapk7	IDA		Rat	PMID:8663194|RGD:2298793
Biological Process	GO:0045765	regulation of angiogenesis	Mapk7	IMP	MGI:MGI:2445409	Mouse	PMID:12221099

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern