Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MAPKAPK2
  • Mouse genes Mapkapk2
  • Rat genes Mapkapk2
  • Zfish genes mapkapk2a,mapkapk2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mapkapk2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016301	kinase activity	mapkapk2a	IMP		Zfish	PMID:19282986
Molecular Function	GO:0005515	protein binding	MAPKAPK2	IPI	UniProtKB:Q15717	Human	PMID:14517288
Molecular Function	GO:0005515	protein binding	MAPKAPK2	IPI	UniProtKB:P26651	Human	PMID:15014438
Molecular Function	GO:0005515	protein binding	MAPKAPK2	IPI	UniProtKB:Q00613	Human	PMID:16278218
Molecular Function	GO:0005515	protein binding	MAPKAPK2	IPI	UniProtKB:Q16539	Human	PMID:17255097
Molecular Function	GO:0005515	protein binding	MAPKAPK2	IPI	UniProtKB:Q9QWH1	Human	PMID:19369945
Molecular Function	GO:0005515	protein binding	MAPKAPK2	IPI	UniProtKB:O95453	Human	PMID:20932473
Molecular Function	GO:0005515	protein binding	MAPKAPK2	IPI	UniProtKB:Q13151	Human	PMID:20932473
Molecular Function	GO:0005515	protein binding	MAPKAPK2	IPI	UniProtKB:P04792	Human	PMID:21575178
Molecular Function	GO:0005515	protein binding	MAPKAPK2	IPI	UniProtKB:Q16539	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	MAPKAPK2	IPI	UniProtKB:Q16539	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	MAPKAPK2	IPI	UniProtKB:Q16539	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	MAPKAPK2	IPI	UniProtKB:P04792	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	MAPKAPK2	IPI	UniProtKB:Q16539	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	MAPKAPK2	IPI	UniProtKB:Q16539	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	MAPKAPK2	IPI	UniProtKB:Q16539	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	MAPKAPK2	IPI	UniProtKB:Q16539	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	MAPKAPK2	IPI	UniProtKB:Q16539	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	MAPKAPK2	IPI	UniProtKB:P04792	Human	PMID:8774846
Molecular Function	GO:0005515	protein binding	Mapkapk2	IPI	UniProtKB:P47811|UniProtKB:Q64028|UniProtKB:Q9QWH1	Mouse	MGI:MGI:3846485|PMID:19369945
Molecular Function	GO:0005515	protein binding	Mapkapk2	IPI	UniProtKB:P18654	Mouse	MGI:MGI:3761050|PMID:17906627
Molecular Function	GO:0004674	protein serine/threonine kinase activity	MAPKAPK2	IDA		Human	PMID:14517288
Molecular Function	GO:0004674	protein serine/threonine kinase activity	MAPKAPK2	IDA		Human	PMID:15014438
Molecular Function	GO:0004674	protein serine/threonine kinase activity	MAPKAPK2	IDA		Human	PMID:15850461
Molecular Function	GO:0004674	protein serine/threonine kinase activity	MAPKAPK2	EXP		Human	PMID:16278218
Molecular Function	GO:0004674	protein serine/threonine kinase activity	MAPKAPK2	IDA		Human	PMID:20932473
Molecular Function	GO:0004674	protein serine/threonine kinase activity	MAPKAPK2	IDA		Human	PMID:24020373
Molecular Function	GO:0004674	protein serine/threonine kinase activity	MAPKAPK2	EXP		Human	PMID:28506461
Molecular Function	GO:0004674	protein serine/threonine kinase activity	MAPKAPK2	EXP		Human	PMID:28920952
Molecular Function	GO:0004674	protein serine/threonine kinase activity	MAPKAPK2	EXP		Human	PMID:7799959
Molecular Function	GO:0004674	protein serine/threonine kinase activity	MAPKAPK2	IDA		Human	PMID:8774846
Molecular Function	GO:0004674	protein serine/threonine kinase activity	MAPKAPK2	IDA		Human	PMID:8846784
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Mapkapk2	IDA		Mouse	MGI:MGI:5306322|PMID:12456657
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Mapkapk2	IDA		Mouse	MGI:MGI:5306333|PMID:9628873
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Mapkapk2	IDA		Mouse	MGI:MGI:3761050|PMID:17906627
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Mapkapk2	IDA		Mouse	PMID:24020373
Cellular Component	GO:0005813	centrosome	MAPKAPK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005737	cytoplasm	MAPKAPK2	IDA		Human	PMID:20932473
Cellular Component	GO:0005737	cytoplasm	Mapkapk2	IDA		Mouse	MGI:MGI:5306333|PMID:9628873
Cellular Component	GO:0005737	cytoplasm	Mapkapk2	IDA		Mouse	PMID:15538386
Cellular Component	GO:0070062	extracellular exosome	MAPKAPK2	HDA		Human	PMID:18570454
Cellular Component	GO:0005654	nucleoplasm	MAPKAPK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	MAPKAPK2	IDA		Human	PMID:20932473
Cellular Component	GO:0005634	nucleus	Mapkapk2	IDA		Mouse	MGI:MGI:5306333|PMID:9628873
Cellular Component	GO:0005634	nucleus	Mapkapk2	IDA		Mouse	PMID:15538386
Biological Process	GO:0070935	3'-UTR-mediated mRNA stabilization	MAPKAPK2	IDA		Human	PMID:14517288
Biological Process	GO:0070935	3'-UTR-mediated mRNA stabilization	MAPKAPK2	IDA		Human	PMID:15014438
Biological Process	GO:0070935	3'-UTR-mediated mRNA stabilization	MAPKAPK2	IDA		Human	PMID:20932473
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	MAPKAPK2	IMP		Human	PMID:18440775
Biological Process	GO:0006974	DNA damage response	MAPKAPK2	IMP		Human	PMID:20932473
Biological Process	GO:0055113	epiboly involved in gastrulation with mouth forming second	mapkapk2a	IMP	ZFIN:ZDB-GENO-090424-5	Zfish	PMID:19282986
Biological Process	GO:0006954	inflammatory response	Mapkapk2	IMP		Mouse	MGI:MGI:1352048|PMID:10559880
Biological Process	GO:0048839	inner ear development	Mapkapk2	IDA		Mouse	PMID:21795542
Biological Process	GO:0010934	macrophage cytokine production	Mapkapk2	IMP		Mouse	PMID:24020373
Biological Process	GO:0044351	macropinocytosis	Mapkapk2	IMP		Mouse	MGI:MGI:3761050|PMID:17906627
Biological Process	GO:0048255	mRNA stabilization	Mapkapk2	IMP	MGI:MGI:2179724	Mouse	PMID:11741878
Biological Process	GO:0038066	p38MAPK cascade	Mapkapk2	IMP		Mouse	PMID:24020373
Biological Process	GO:0018105	peptidyl-serine phosphorylation	MAPKAPK2	IDA		Human	PMID:15850461
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Mapkapk2	IMP		Mouse	PMID:24020373
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Mapkapk2	IMP		Mouse	PMID:24020373
Biological Process	GO:0006468	protein phosphorylation	Mapkapk2	IDA		Mouse	MGI:MGI:5306333|PMID:9628873
Biological Process	GO:0032675	regulation of interleukin-6 production	Mapkapk2	IMP		Mouse	MGI:MGI:1352048|PMID:10559880
Biological Process	GO:0032680	regulation of tumor necrosis factor production	MAPKAPK2	IDA		Human	PMID:15014438
Biological Process	GO:0032680	regulation of tumor necrosis factor production	Mapkapk2	IMP		Mouse	MGI:MGI:1352048|PMID:10559880
Biological Process	GO:0034097	response to cytokine	MAPKAPK2	IDA		Human	PMID:8774846
Biological Process	GO:0032496	response to lipopolysaccharide	Mapkapk2	IMP		Mouse	MGI:MGI:1352048|PMID:10559880
Biological Process	GO:0032496	response to lipopolysaccharide	Mapkapk2	IMP		Mouse	MGI:MGI:3761050|PMID:17906627
Biological Process	GO:0002224	toll-like receptor signaling pathway	Mapkapk2	IMP		Mouse	MGI:MGI:3761050|PMID:17906627
Biological Process	GO:0032640	tumor necrosis factor production	Mapkapk2	IMP		Mouse	PMID:24020373
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	MAPKAPK2	IMP		Human	PMID:18440775

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern