Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MARCO
  • Mouse genes Marco
  • Rat genes Marco
  • Zfish genes marco
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Marco

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001540	amyloid-beta binding	Marco	IMP		Rat	PMID:15987691|RGD:13432286
Molecular Function	GO:0038024	cargo receptor activity	Marco	IMP		Rat	PMID:15987691|RGD:13432286
Molecular Function	GO:0001664	G protein-coupled receptor binding	MARCO	IPI	UniProtKB:P25090	Human	PMID:20141570
Cellular Component	GO:0005737	cytoplasm	Marco	IDA		Rat	PMID:20141570|RGD:12907556
Cellular Component	GO:0005886	plasma membrane	Marco	IDA		Rat	PMID:20141570|RGD:12907556
Biological Process	GO:0097242	amyloid-beta clearance	Marco	IMP		Rat	PMID:15987691|RGD:13432286
Biological Process	GO:0043277	apoptotic cell clearance	Marco	IMP		Mouse	PMID:19201851
Biological Process	GO:0042742	defense response to bacterium	marco	IMP	ZFIN:ZDB-MRPHLNO-150107-3	Zfish	PMID:25086293
Biological Process	GO:0042742	defense response to bacterium	marco	IMP	ZFIN:ZDB-MRPHLNO-150107-2	Zfish	PMID:25086293
Biological Process	GO:0006897	endocytosis	Marco	IMP		Mouse	PMID:19201851
Biological Process	GO:0006909	phagocytosis	marco	IMP	ZFIN:ZDB-MRPHLNO-150107-3	Zfish	PMID:25086293
Biological Process	GO:0006909	phagocytosis	marco	IMP	ZFIN:ZDB-MRPHLNO-150107-2	Zfish	PMID:25086293
Biological Process	GO:0006911	phagocytosis, engulfment	Marco	IMP		Rat	PMID:15987691|RGD:13432286
Biological Process	GO:0006898	receptor-mediated endocytosis	Marco	IMP		Rat	PMID:15987691|RGD:13432286

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern