Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MARK2
  • Mouse genes Mark2
  • Rat genes Mark2
  • Zfish genes mark2a,mark2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mark2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	MARK2	IDA		Human	PMID:14976552
Molecular Function	GO:0045296	cadherin binding	MARK2	HDA		Human	PMID:25468996
Molecular Function	GO:0000287	magnesium ion binding	MARK2	IDA		Human	PMID:14976552
Molecular Function	GO:0140677	molecular function activator activity	Mark2	EXP		Rat	PMID:16472737|RGD:152995552
Molecular Function	GO:0005515	protein binding	MARK2	IPI	UniProtKB:P63104	Human	PMID:14676191
Molecular Function	GO:0005515	protein binding	MARK2	IPI	UniProtKB:Q04917	Human	PMID:14676191
Molecular Function	GO:0005515	protein binding	MARK2	IPI	UniProtKB:Q9BYG4	Human	PMID:14676191
Molecular Function	GO:0005515	protein binding	MARK2	IPI	UniProtKB:P63104	Human	PMID:15161933
Molecular Function	GO:0005515	protein binding	MARK2	IPI	UniProtKB:P63104	Human	PMID:15324659
Molecular Function	GO:0005515	protein binding	MARK2	IPI	UniProtKB:P63104	Human	PMID:16306228
Molecular Function	GO:0005515	protein binding	MARK2	IPI	UniProtKB:Q7L804	Human	PMID:16775013
Molecular Function	GO:0005515	protein binding	MARK2	IPI	UniProtKB:P31946	Human	PMID:16959763
Molecular Function	GO:0005515	protein binding	MARK2	IPI	UniProtKB:P61981	Human	PMID:16959763
Molecular Function	GO:0005515	protein binding	MARK2	IPI	UniProtKB:Q04917	Human	PMID:16959763
Molecular Function	GO:0005515	protein binding	MARK2	IPI	UniProtKB:Q8WUI4	Human	PMID:16980613
Molecular Function	GO:0005515	protein binding	MARK2	IPI	UniProtKB:Q14012	Human	PMID:17442826
Molecular Function	GO:0005515	protein binding	MARK2	IPI	UniProtKB:Q04917	Human	PMID:17979178
Molecular Function	GO:0005515	protein binding	MARK2	IPI	UniProtKB:Q04917	Human	PMID:19553522
Molecular Function	GO:0005515	protein binding	MARK2	IPI	UniProtKB:Q04917	Human	PMID:19615732
Molecular Function	GO:0005515	protein binding	MARK2	IPI	UniProtKB:P55980	Human	PMID:19966800
Molecular Function	GO:0005515	protein binding	MARK2	IPI	UniProtKB:Q9NQT8	Human	PMID:20194617
Molecular Function	GO:0005515	protein binding	MARK2	IPI	UniProtKB:Q3UHU5-1	Human	PMID:23902687
Molecular Function	GO:0005515	protein binding	MARK2	IPI	UniProtKB:Q9Y4B5-2	Human	PMID:23902687
Molecular Function	GO:0005515	protein binding	MARK2	IPI	UniProtKB:P31946	Human	PMID:24255178
Molecular Function	GO:0005515	protein binding	MARK2	IPI	UniProtKB:P61981	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	MARK2	IPI	UniProtKB:P63104	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	MARK2	IPI	UniProtKB:Q04917	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	MARK2	IPI	UniProtKB:P31946	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	MARK2	IPI	UniProtKB:P61981	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	MARK2	IPI	UniProtKB:P63104	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	MARK2	IPI	UniProtKB:Q04917	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	Mark2	IPI	UniProtKB:O43602	Rat	PMID:14741102|RGD:8554024
Molecular Function	GO:0005515	protein binding	Mark2	IPI	UniProtKB:P10636	Rat	PMID:24251416|RGD:13602001
Molecular Function	GO:0004674	protein serine/threonine kinase activity	MARK2	IDA		Human	PMID:14976552
Molecular Function	GO:0004674	protein serine/threonine kinase activity	MARK2	IDA		Human	PMID:16775013
Molecular Function	GO:0004674	protein serine/threonine kinase activity	MARK2	IDA		Human	PMID:16980613
Molecular Function	GO:0004674	protein serine/threonine kinase activity	MARK2	IDA		Human	PMID:20194617
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Mark2	IDA		Rat	PMID:14741102|RGD:8554024
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Mark2	IMP		Rat	PMID:24251416|RGD:13602001
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Mark2	IMP		Rat	PMID:9108484|RGD:633320
Molecular Function	GO:0003723	RNA binding	MARK2	HDA		Human	PMID:22658674
Molecular Function	GO:0048156	tau protein binding	Mark2	IPI	UniProtKB:P10636	Rat	PMID:24251416|RGD:13602001
Molecular Function	GO:0050321	tau-protein kinase activity	MARK2	IMP		Human	PMID:23666762
Molecular Function	GO:0050321	tau-protein kinase activity	Mark2	IDA		Rat	PMID:14517247|RGD:8553906
Molecular Function	GO:0050321	tau-protein kinase activity	Mark2	IMP		Rat	PMID:24251416|RGD:13602001
Cellular Component	GO:0005884	actin filament	MARK2	IDA		Human	PMID:23902687
Cellular Component	GO:0045180	basal cortex	Mark2	IDA		Mouse	PMID:15950600
Cellular Component	GO:0005737	cytoplasm	MARK2	IDA		Human	PMID:23666762
Cellular Component	GO:0030425	dendrite	MARK2	IDA		Human	PMID:23666762
Cellular Component	GO:0098978	glutamatergic synapse	Mark2	IDA		Mouse	PMID:21865452
Cellular Component	GO:0098978	glutamatergic synapse	Mark2	IDA		Rat	PMID:22807451|RGD:155230723
Cellular Component	GO:0098978	glutamatergic synapse	Mark2	IMP		Rat	PMID:22807451|RGD:155230723
Cellular Component	GO:0016328	lateral plasma membrane	MARK2	IDA		Human	PMID:23902687
Cellular Component	GO:0016020	membrane	MARK2	IMP		Human	PMID:14976552
Cellular Component	GO:0016020	membrane	Mark2	IDA		Rat	PMID:14741102|RGD:8554024
Cellular Component	GO:0097427	microtubule bundle	MARK2	IDA		Human	PMID:23902687
Cellular Component	GO:0005654	nucleoplasm	MARK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Mark2	IDA		Mouse	PMID:15950600
Cellular Component	GO:0005886	plasma membrane	MARK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	MARK2	IDA		Human	PMID:23902687
Cellular Component	GO:0098794	postsynapse	Mark2	IDA		Mouse	PMID:21865452
Biological Process	GO:0061564	axon development	Mark2	IMP		Rat	PMID:16717194|RGD:13602002
Biological Process	GO:0030010	establishment of cell polarity	MARK2	IDA		Human	PMID:12429843
Biological Process	GO:0071963	establishment or maintenance of cell polarity regulating cell shape	Mark2	IMP		Rat	PMID:16717194|RGD:13602002
Biological Process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	MARK2	IDA		Human	PMID:15324659
Biological Process	GO:0035556	intracellular signal transduction	MARK2	IDA		Human	PMID:14976552
Biological Process	GO:0001764	neuron migration	Mark2	IDA		Rat	PMID:14741102|RGD:8554024
Biological Process	GO:0018105	peptidyl-serine phosphorylation	MARK2	IDA		Human	PMID:10542369
Biological Process	GO:0018105	peptidyl-serine phosphorylation	MARK2	IDA		Human	PMID:16717194
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Mark2	IDA		Rat	PMID:10542369|RGD:13524612
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Mark2	IMP		Rat	PMID:16717194|RGD:13602002
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Mark2	IMP		Rat	PMID:24251416|RGD:13602001
Biological Process	GO:0010976	positive regulation of neuron projection development	MARK2	IDA		Human	PMID:12429843
Biological Process	GO:0046777	protein autophosphorylation	Mark2	IDA		Rat	PMID:14517247|RGD:8553906
Biological Process	GO:0006468	protein phosphorylation	MARK2	IDA		Human	PMID:14976552
Biological Process	GO:0006468	protein phosphorylation	MARK2	IMP	UniProtKB:Q96L34	Human	PMID:23666762
Biological Process	GO:0006468	protein phosphorylation	Mark2	IMP		Rat	PMID:9108484|RGD:633320
Biological Process	GO:0050770	regulation of axonogenesis	MARK2	IMP		Human	PMID:20194617
Biological Process	GO:0051493	regulation of cytoskeleton organization	Mark2	IDA		Rat	PMID:14517247|RGD:8553906
Biological Process	GO:1904526	regulation of microtubule binding	Mark2	IMP	UniProtKB:P10636	Rat	PMID:24251416|RGD:13602001
Biological Process	GO:0070507	regulation of microtubule cytoskeleton organization	MARK2	IDA		Human	PMID:10542369
Biological Process	GO:0070507	regulation of microtubule cytoskeleton organization	Mark2	IDA		Rat	PMID:10542369|RGD:13524612
Biological Process	GO:0099175	regulation of postsynapse organization	Mark2	IDA		Rat	PMID:22807451|RGD:155230723
Biological Process	GO:0099175	regulation of postsynapse organization	Mark2	IMP		Rat	PMID:22807451|RGD:155230723

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern