Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MARK4
  • Mouse genes Mark4
  • Rat genes Mark4
  • Zfish genes mark4a,mark4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mark4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008093	cytoskeletal anchor activity	MARK4	IDA		Human	PMID:28656979
Molecular Function	GO:0008093	cytoskeletal anchor activity	Mark4	IDA		Mouse	MGI:MGI:5921465|PMID:28656979
Molecular Function	GO:0043015	gamma-tubulin binding	MARK4	IDA		Human	PMID:14594945
Molecular Function	GO:0008017	microtubule binding	MARK4	IDA		Human	PMID:14594945
Molecular Function	GO:0005515	protein binding	MARK4	IPI	UniProtKB:P23258	Human	PMID:14594945
Molecular Function	GO:0005515	protein binding	MARK4	IPI	UniProtKB:P23258	Human	PMID:14676191
Molecular Function	GO:0005515	protein binding	MARK4	IPI	UniProtKB:P41743	Human	PMID:14676191
Molecular Function	GO:0005515	protein binding	MARK4	IPI	UniProtKB:P60953	Human	PMID:14676191
Molecular Function	GO:0005515	protein binding	MARK4	IPI	UniProtKB:Q04917	Human	PMID:14676191
Molecular Function	GO:0005515	protein binding	MARK4	IPI	UniProtKB:Q15831	Human	PMID:14676191
Molecular Function	GO:0005515	protein binding	MARK4	IPI	UniProtKB:Q8ND90	Human	PMID:14676191
Molecular Function	GO:0005515	protein binding	MARK4	IPI	UniProtKB:Q9BYG4	Human	PMID:14676191
Molecular Function	GO:0005515	protein binding	MARK4	IPI	UniProtKB:Q04917	Human	PMID:16959763
Molecular Function	GO:0005515	protein binding	MARK4	IPI	UniProtKB:P10636	Human	PMID:23666762
Molecular Function	GO:0005515	protein binding	MARK4	IPI	UniProtKB:Q15323	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MARK4	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MARK4	IPI	UniProtKB:P07948	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MARK4	IPI	UniProtKB:P48730-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MARK4	IPI	UniProtKB:Q06481-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Mark4	IPI	RGD:1306533	Rat	PMID:22670221|RGD:6784500
Molecular Function	GO:0004674	protein serine/threonine kinase activity	MARK4	IDA		Human	PMID:15009667
Molecular Function	GO:0050321	tau-protein kinase activity	MARK4	IDA		Human	PMID:14594945
Molecular Function	GO:0050321	tau-protein kinase activity	MARK4	IMP		Human	PMID:23666762
Molecular Function	GO:0050321	tau-protein kinase activity	MARK4	IMP		Human	PMID:27708431
Cellular Component	GO:0005813	centrosome	MARK4	IDA		Human	PMID:14594945
Cellular Component	GO:0005813	centrosome	MARK4	IDA		Human	PMID:25123532
Cellular Component	GO:0036064	ciliary basal body	MARK4	IMP		Human	PMID:23400999
Cellular Component	GO:0005737	cytoplasm	MARK4	IDA		Human	PMID:23666762
Cellular Component	GO:0005829	cytosol	MARK4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030425	dendrite	MARK4	IDA		Human	PMID:23666762
Cellular Component	GO:0000930	gamma-tubulin complex	MARK4	IDA		Human	PMID:25123532
Cellular Component	GO:0015630	microtubule cytoskeleton	MARK4	IDA		Human	PMID:14594945
Cellular Component	GO:0005815	microtubule organizing center	MARK4	IDA		Human	PMID:28656979
Cellular Component	GO:0005815	microtubule organizing center	MARK4	IDA		Human	PMID:14594945
Cellular Component	GO:0005815	microtubule organizing center	Mark4	IDA		Mouse	MGI:MGI:5921465|PMID:28656979
Cellular Component	GO:0030496	midbody	MARK4	IDA		Human	PMID:25123532
Cellular Component	GO:0043005	neuron projection	MARK4	IDA		Human	PMID:14594945
Biological Process	GO:0044782	cilium organization	MARK4	IGI	UniProtKB:Q5BJF6	Human	PMID:23400999
Biological Process	GO:0001578	microtubule bundle formation	MARK4	IEP		Human	PMID:14594945
Biological Process	GO:0000226	microtubule cytoskeleton organization	MARK4	IMP		Human	PMID:14594945
Biological Process	GO:0007399	nervous system development	MARK4	IDA		Human	PMID:14594945
Biological Process	GO:0045787	positive regulation of cell cycle	MARK4	IDA		Human	PMID:26882547
Biological Process	GO:0045724	positive regulation of cilium assembly	MARK4	IMP		Human	PMID:23400999
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	MARK4	IDA		Human	PMID:28656979
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	Mark4	IDA		Mouse	MGI:MGI:5921465|PMID:28656979
Biological Process	GO:1904781	positive regulation of protein localization to centrosome	MARK4	IMP		Human	PMID:23400999
Biological Process	GO:0006468	protein phosphorylation	MARK4	IMP	UniProtKB:Q96L34	Human	PMID:23666762
Biological Process	GO:0046605	regulation of centrosome cycle	MARK4	IMP		Human	PMID:25123532

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern