Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MAT2A
  • Mouse genes Mat2a
  • Rat genes Mat2a
  • Zfish genes mat2aa,mat2ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mat2a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016597	amino acid binding	Mat2a	IDA		Rat	PMID:12029623|RGD:727376
Molecular Function	GO:0005524	ATP binding	Mat2a	IDA		Rat	PMID:12029623|RGD:727376
Molecular Function	GO:0042802	identical protein binding	MAT2A	IPI	UniProtKB:P31153	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	MAT2A	IPI	UniProtKB:P31153	Human	PMID:32296183
Molecular Function	GO:0004478	methionine adenosyltransferase activity	MAT2A	IDA		Human	PMID:10644686
Molecular Function	GO:0004478	methionine adenosyltransferase activity	MAT2A	IDA		Human	PMID:25075345
Molecular Function	GO:0004478	methionine adenosyltransferase activity	MAT2A	IDA		Human	PMID:7665609
Molecular Function	GO:0004478	methionine adenosyltransferase activity	Mat2a	IDA		Mouse	PMID:12023972
Molecular Function	GO:0004478	methionine adenosyltransferase activity	Mat2a	IDA		Rat	PMID:10898761|RGD:7242777
Molecular Function	GO:0004478	methionine adenosyltransferase activity	Mat2a	IDA		Rat	PMID:12029623|RGD:727376
Molecular Function	GO:0005515	protein binding	MAT2A	IPI	UniProtKB:Q9NZL9	Human	PMID:10644686
Molecular Function	GO:0005515	protein binding	MAT2A	IPI	UniProtKB:Q9NZL9	Human	PMID:25075345
Molecular Function	GO:0005515	protein binding	MAT2A	IPI	UniProtKB:Q9NZL9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MAT2A	IPI	UniProtKB:Q00266	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	MAT2A	IPI	UniProtKB:O43663	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAT2A	IPI	UniProtKB:Q00266	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAT2A	IPI	UniProtKB:O43741	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAT2A	IPI	UniProtKB:O95789-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAT2A	IPI	UniProtKB:P02795	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAT2A	IPI	UniProtKB:P08195-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAT2A	IPI	UniProtKB:P15976-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAT2A	IPI	UniProtKB:P57052	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAT2A	IPI	UniProtKB:P80217-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAT2A	IPI	UniProtKB:Q13573	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAT2A	IPI	UniProtKB:Q6P1L5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAT2A	IPI	UniProtKB:Q6ZP82	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAT2A	IPI	UniProtKB:Q86W54-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAT2A	IPI	UniProtKB:Q8IUI8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAT2A	IPI	UniProtKB:Q8N488	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAT2A	IPI	UniProtKB:Q8WZ19	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAT2A	IPI	UniProtKB:Q96IK1-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAT2A	IPI	UniProtKB:Q96NX5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAT2A	IPI	UniProtKB:Q9BRX2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAT2A	IPI	UniProtKB:Q9UIH9	Human	PMID:32814053
Molecular Function	GO:0036094	small molecule binding	MAT2A	EXP		Human	PMID:26858410
Cellular Component	GO:0005829	cytosol	Mat2a	IDA		Rat	PMID:10898761|RGD:7242777
Cellular Component	GO:0048269	methionine adenosyltransferase complex	MAT2A	IPI		Human	PMID:25075345
Cellular Component	GO:0048269	methionine adenosyltransferase complex	MAT2A	IDA		Human	PMID:10644686
Cellular Component	GO:0048269	methionine adenosyltransferase complex	MAT2A	IDA		Human	PMID:25075345
Biological Process	GO:0055013	cardiac muscle cell development	mat2aa	IMP	ZFIN:ZDB-GENO-140212-3	Zfish	PMID:23283723
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Mat2a	IEP		Mouse	PMID:20439489
Biological Process	GO:0007623	circadian rhythm	Mat2a	IDA		Rat	PMID:15504733|RGD:1598692
Biological Process	GO:0072359	circulatory system development	mat2aa	IMP	ZFIN:ZDB-MRPHLNO-150225-4	Zfish	PMID:25557781
Biological Process	GO:0051291	protein heterooligomerization	MAT2A	IDA		Human	PMID:25075345
Biological Process	GO:0034214	protein hexamerization	MAT2A	IDA		Human	PMID:25075345
Biological Process	GO:0051591	response to cAMP	Mat2a	IDA		Rat	PMID:15504733|RGD:1598692
Biological Process	GO:0009725	response to hormone	Mat2a	IDA		Rat	PMID:15504733|RGD:1598692
Biological Process	GO:0009416	response to light stimulus	Mat2a	IEP		Rat	PMID:15504733|RGD:1598692
Biological Process	GO:0009410	response to xenobiotic stimulus	Mat2a	IDA		Rat	PMID:15504733|RGD:1598692
Biological Process	GO:0006556	S-adenosylmethionine biosynthetic process	MAT2A	IDA		Human	PMID:10644686
Biological Process	GO:0006556	S-adenosylmethionine biosynthetic process	MAT2A	IDA		Human	PMID:25075345
Biological Process	GO:0006556	S-adenosylmethionine biosynthetic process	Mat2a	IDA		Mouse	PMID:12023972
Biological Process	GO:0006556	S-adenosylmethionine biosynthetic process	Mat2a	IDA		Rat	PMID:10898761|RGD:7242777
Biological Process	GO:0006556	S-adenosylmethionine biosynthetic process	Mat2a	IDA		Rat	PMID:12029623|RGD:727376

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern