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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Mavs

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mavs
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0050700CARD domain bindingMAVSIPIUniProtKB:O95786HumanPMID:16127453
Molecular FunctionGO:0050700CARD domain bindingMAVSIPIUniProtKB:Q9BYX4HumanPMID:16127453
Molecular FunctionGO:0042802identical protein bindingMAVSIDAHumanPMID:16127453
Molecular FunctionGO:0042802identical protein bindingMAVSIDAHumanPMID:26803627
Molecular FunctionGO:0060090molecular adaptor activityMAVSIDAHumanPMID:16858409
Molecular FunctionGO:0060090molecular adaptor activityMAVSIDAHumanPMID:20451243
Molecular FunctionGO:0140693molecular condensate scaffold activityMAVSIDAHumanPMID:27992402
Molecular FunctionGO:0140677molecular function activator activityMAVSIDAHumanPMID:16127453
Molecular FunctionGO:0140677molecular function activator activityMAVSIDAHumanPMID:26803627
Molecular FunctionGO:0140677molecular function activator activityMAVSIDAHumanPMID:34880843
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q13158HumanPMID:16127453
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:O95786HumanPMID:16177806
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q14164HumanPMID:16177806
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q96EQ8HumanPMID:17460044
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q9BYX4HumanPMID:17600090
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q9NQC7HumanPMID:18636086
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q86WV6HumanPMID:18818105
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q14164HumanPMID:19153231
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:O95786HumanPMID:19164550
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q07021HumanPMID:19164550
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:O95786HumanPMID:19193793
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q86WV6HumanPMID:19416887
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:P12931HumanPMID:19419966
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q15366HumanPMID:19881509
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q13114HumanPMID:19893624
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:P00519HumanPMID:19914245
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:O95786HumanPMID:20007272
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q8IWA4HumanPMID:20019757
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:O00571HumanPMID:20127681
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:O94826HumanPMID:20628368
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q69027HumanPMID:21068253
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:O95786HumanPMID:21102435
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:O14879HumanPMID:21813773
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:O43353HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:O95786HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:P42224HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:P46379HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q12933HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q13137HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q13568HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q14139HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q14164HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q9BYX4HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q9UHD2HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q9Y4K3HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q9Y6K5HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q86WV6HumanPMID:22000020
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:O95786HumanPMID:22301138
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q9BYX4HumanPMID:22301138
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q86WV6HumanPMID:22312431
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:O75179HumanPMID:22328336
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:O95786HumanPMID:22623778
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q9BYX4HumanPMID:22623778
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:O43657HumanPMID:22908223
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q14653HumanPMID:22908223
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q86WV6HumanPMID:22908223
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q9Y4K3HumanPMID:22908223
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q86WV6HumanPMID:22911572
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q6WB96HumanPMID:23015697
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q969V5HumanPMID:23399697
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q96DX7HumanPMID:23460740
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q86WV6HumanPMID:23542348
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q96P20HumanPMID:23582325
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:O95786HumanPMID:24478431
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q86WV6HumanPMID:24622840
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:A2T3M4HumanPMID:24643253
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q9UHD2HumanPMID:24643253
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q14164HumanPMID:24706939
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:O43143HumanPMID:24990078
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:P59636HumanPMID:25135833
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q9Y2W7HumanPMID:25416956
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q9Y4K3HumanPMID:26385923
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:O00571HumanPMID:27980081
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q13114HumanPMID:27980081
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q14164HumanPMID:28011935
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q14166HumanPMID:28011935
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q9UHD2HumanPMID:28011935
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q96I76HumanPMID:28414768
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q12933HumanPMID:30561431
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q9H078HumanPMID:31522117
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:O75746HumanPMID:31767682
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q12933HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:P12830HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:P27797HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:P36957HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:P37173HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q8TDX7HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:P0DTC5HumanPMID:33110251
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:O95786HumanPMID:33372174
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:P0DTC5HumanPMID:33372174
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q9BYX4HumanPMID:33372174
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q9UHD2HumanPMID:33372174
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:P0DTD8HumanPMID:33845483
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:Q7TFA1HumanPMID:33845483
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:O95786HumanPMID:33976430
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:O95786HumanPMID:34544279
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:P0DTD1:PRO_0000449623HumanPMID:34544279
Molecular FunctionGO:0005515protein bindingMAVSIPIUniProtKB:O95786HumanPMID:35075101
Molecular FunctionGO:0005515protein bindingMavsIPIUniProtKB:Q60803MouseMGI:MGI:5508627|PMID:16858409
Molecular FunctionGO:0005515protein bindingMavsIPIUniProtKB:Q80VY9MouseMGI:MGI:6120210|PMID:24037184
Molecular FunctionGO:0005515protein bindingMavsIPIUniProtKB:Q3UDK1MouseMGI:MGI:3831253|PMID:18849341
Molecular FunctionGO:0046982protein heterodimerization activitymavsIPIZFIN:ZDB-GENE-081104-438ZfishPMID:24116956
Molecular FunctionGO:0019901protein kinase bindingMAVSIPIUniProtKB:Q13546HumanPMID:16127453
Molecular FunctionGO:0039552RIG-I bindingMAVSIDAHumanPMID:16127453
Molecular FunctionGO:0035591signaling adaptor activityMAVSIMPHumanPMID:20451243
Molecular FunctionGO:0035591signaling adaptor activityMAVSIDAHumanPMID:23582325
Molecular FunctionGO:0035591signaling adaptor activityMAVSIDAHumanPMID:26314863
Molecular FunctionGO:0035591signaling adaptor activityMAVSIDAHumanPMID:34880843
Molecular FunctionGO:0035591signaling adaptor activityMavsIMPMouseMGI:MGI:4881394|PMID:20451243
Molecular FunctionGO:0035591signaling adaptor activityMavsIDAMouseMGI:MGI:5492224|PMID:23582325
Cellular ComponentGO:0031966mitochondrial membraneMAVSIDAHumanPMID:20451243
Cellular ComponentGO:0005741mitochondrial outer membraneMAVSIDAHumanPMID:16127453
Cellular ComponentGO:0005741mitochondrial outer membraneMAVSIDAHumanPMID:26314863
Cellular ComponentGO:0005741mitochondrial outer membraneMAVSIDAHumanPMID:18818105
Cellular ComponentGO:0005739mitochondrionMAVSIDAHumanPMID:27992402
Cellular ComponentGO:0005739mitochondrionMAVSIDAHumanPMID:31390091
Cellular ComponentGO:0005739mitochondrionMAVSIDAHumanGO_REF:0000052
Cellular ComponentGO:0005739mitochondrionMAVSIDAHumanPMID:20628368
Cellular ComponentGO:0005739mitochondrionMAVSIDAHumanPMID:23582325
Cellular ComponentGO:0005739mitochondrionMavsIDAMouseMGI:MGI:4881394|PMID:20451243
Cellular ComponentGO:0005739mitochondrionMavsIDAMouseMGI:MGI:5492224|PMID:23582325
Cellular ComponentGO:0005739mitochondrionMavsHDAMousePMID:18614015
Cellular ComponentGO:0005739mitochondrionMavsIDAMousePMID:31390091
Cellular ComponentGO:0005739mitochondrionmavsIDAZfishPMID:23091644
Cellular ComponentGO:0005778peroxisomal membraneMAVSIDAHumanPMID:20451243
Cellular ComponentGO:0005777peroxisomeMavsIDAMouseMGI:MGI:4881394|PMID:20451243
Cellular ComponentGO:0005777peroxisomeMavsIDAMousePMID:22745163
Biological ProcessGO:0002218activation of innate immune responseMAVSIMPHumanPMID:18818105
Biological ProcessGO:0002218activation of innate immune responseMAVSIDAHumanPMID:20628368
Biological ProcessGO:0140374antiviral innate immune responseMAVSIDAHumanPMID:27992402
Biological ProcessGO:0071360cellular response to exogenous dsRNAMAVSIMPHumanPMID:16127453
Biological ProcessGO:0071360cellular response to exogenous dsRNAMAVSIMPHumanPMID:21957149
Biological ProcessGO:0002753cytosolic pattern recognition receptor signaling pathwayMAVSIDAHumanPMID:16125763
Biological ProcessGO:0002753cytosolic pattern recognition receptor signaling pathwaymavsIDAZfishPMID:23091644
Biological ProcessGO:0042742defense response to bacteriumMAVSIMPHumanPMID:19631370
Biological ProcessGO:0051607defense response to virusMAVSIDAHumanPMID:20451243
Biological ProcessGO:0051607defense response to virusmavsIDAZfishPMID:19474100
Biological ProcessGO:0045087innate immune responseMAVSIDAHumanPMID:23951545
Biological ProcessGO:0045087innate immune responseMAVSIMPHumanPMID:19609254
Biological ProcessGO:0045087innate immune responseMAVSIMPHumanPMID:19631370
Biological ProcessGO:0045071negative regulation of viral genome replicationMAVSIDAHumanPMID:20451243
Biological ProcessGO:0045071negative regulation of viral genome replicationMavsIMPMouseMGI:MGI:4881394|PMID:20451243
Biological ProcessGO:0071651positive regulation of chemokine (C-C motif) ligand 5 productionMAVSIDAHumanPMID:16127453
Biological ProcessGO:0002230positive regulation of defense response to virus by hostMAVSIDAHumanPMID:16127453
Biological ProcessGO:0002230positive regulation of defense response to virus by hostMAVSIMPHumanPMID:19609254
Biological ProcessGO:0002230positive regulation of defense response to virus by hostMAVSIDAHumanPMID:20628368
Biological ProcessGO:0002230positive regulation of defense response to virus by hostMavsIMPMGI:MGI:3654145MousePMID:18780793
Biological ProcessGO:0051091positive regulation of DNA-binding transcription factor activityMAVSIDAHumanPMID:16127453
Biological ProcessGO:0051091positive regulation of DNA-binding transcription factor activityMAVSIDAHumanPMID:18818105
Biological ProcessGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingMAVSHMPHumanPMID:12761501
Biological ProcessGO:0032727positive regulation of interferon-alpha productionMAVSIDAHumanPMID:16127453
Biological ProcessGO:0032727positive regulation of interferon-alpha productionMAVSIMPHumanPMID:19609254
Biological ProcessGO:0032727positive regulation of interferon-alpha productionMAVSIMPHumanPMID:21957149
Biological ProcessGO:0032727positive regulation of interferon-alpha productionMavsIMPMGI:MGI:6430641MousePMID:31390091
Biological ProcessGO:0032728positive regulation of interferon-beta productionMAVSIDAHumanPMID:16127453
Biological ProcessGO:0032728positive regulation of interferon-beta productionMAVSIMPHumanPMID:19609254
Biological ProcessGO:0032728positive regulation of interferon-beta productionMAVSIMPHumanPMID:19631370
Biological ProcessGO:0032728positive regulation of interferon-beta productionMAVSIDAHumanPMID:20628368
Biological ProcessGO:0032728positive regulation of interferon-beta productionMAVSIMPHumanPMID:21957149
Biological ProcessGO:0032728positive regulation of interferon-beta productionMavsIMPMGI:MGI:6430641MousePMID:31390091
Biological ProcessGO:0032755positive regulation of interleukin-6 productionMAVSIMPHumanPMID:21957149
Biological ProcessGO:0032755positive regulation of interleukin-6 productionMavsIMPMGI:MGI:6430641MousePMID:31390091
Biological ProcessGO:0032757positive regulation of interleukin-8 productionMAVSIDAHumanPMID:16127453
Biological ProcessGO:0071660positive regulation of IP-10 productionMAVSIDAHumanPMID:16127453
Biological ProcessGO:0002735positive regulation of myeloid dendritic cell cytokine productionMavsIMPMouseMGI:MGI:5050760|PMID:21703541
Biological ProcessGO:1900227positive regulation of NLRP3 inflammasome complex assemblyMAVSIDAHumanPMID:23582325
Biological ProcessGO:1900227positive regulation of NLRP3 inflammasome complex assemblyMavsIDAMouseMGI:MGI:5492224|PMID:23582325
Biological ProcessGO:0042307positive regulation of protein import into nucleusMAVSIDAHumanPMID:18818105
Biological ProcessGO:0001934positive regulation of protein phosphorylationMAVSIDAHumanPMID:16127453
Biological ProcessGO:0060760positive regulation of response to cytokine stimulusMAVSIMPHumanPMID:21957149
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIMAVSIDAHumanPMID:16127453
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIMAVSIDAHumanPMID:18818105
Biological ProcessGO:0032760positive regulation of tumor necrosis factor productionMAVSIDAHumanPMID:16127453
Biological ProcessGO:0032760positive regulation of tumor necrosis factor productionMAVSIMPHumanPMID:21957149
Biological ProcessGO:0032481positive regulation of type I interferon productionMAVSIDAHumanPMID:16858409
Biological ProcessGO:0032481positive regulation of type I interferon productionMavsIMPMGI:MGI:3654145MousePMID:18780793
Biological ProcessGO:0060340positive regulation of type I interferon-mediated signaling pathwayMAVSIDAHumanPMID:16127453
Biological ProcessGO:0060340positive regulation of type I interferon-mediated signaling pathwayMAVSIDAHumanPMID:20451243
Biological ProcessGO:0070585protein localization to mitochondrionMAVSIDAHumanPMID:23582325
Biological ProcessGO:0070585protein localization to mitochondrionMavsIDAMouseMGI:MGI:5492224|PMID:23582325
Biological ProcessGO:0006355regulation of DNA-templated transcriptionmavsIDAZfishPMID:27235368
Biological ProcessGO:0006355regulation of DNA-templated transcriptionmavsIGIZFIN:ZDB-GENE-081104-438ZfishPMID:24116956
Biological ProcessGO:0006355regulation of DNA-templated transcriptionmavsIGIZFIN:ZDB-GENE-061108-4ZfishPMID:27235368
Biological ProcessGO:0006355regulation of DNA-templated transcriptionmavsIDAZfishPMID:24116956
Biological ProcessGO:1900063regulation of peroxisome organizationMAVSIMPHumanPMID:20451243
Biological ProcessGO:1900063regulation of peroxisome organizationMavsIMPMouseMGI:MGI:4881394|PMID:20451243
Biological ProcessGO:0009617response to bacteriummavsIDAZfishPMID:27235368
Biological ProcessGO:0009615response to virusmavsIDAZfishPMID:27235368
Biological ProcessGO:0039529RIG-I signaling pathwayMavsIGIMGI:MGI:1914320MousePMID:22745163
Biological ProcessGO:0007165signal transductionMAVSIMPHumanPMID:20451243
Biological ProcessGO:0007165signal transductionMavsIMPMouseMGI:MGI:4881394|PMID:20451243

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory