Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MAX
  • Mouse genes Max
  • Rat genes Max
  • Zfish genes max
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Max

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	MAX	IDA		Human	PMID:9399572
Molecular Function	GO:0003677	DNA binding	Max	IDA		Mouse	PMID:12970171
Molecular Function	GO:0003677	DNA binding	Max	IDA		Mouse	PMID:8521822
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Max	IMP		Rat	PMID:17341548|RGD:2290581
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	MAX	IDA		Human	PMID:8425218
Molecular Function	GO:0140297	DNA-binding transcription factor binding	MAX	IPI	UniProtKB:P01106	Human	PMID:15674325
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	MAX	IDA		Human	PMID:8521822
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	MAX	IDA		Human	PMID:26070438
Molecular Function	GO:0070888	E-box binding	MAX	IMP		Human	PMID:16171389
Molecular Function	GO:0042802	identical protein binding	Max	IPI	RGD:621101	Rat	PMID:7791753|RGD:2316831
Molecular Function	GO:0003676	nucleic acid binding	MAX	EXP		Human	PMID:9399572
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P04198	Human	PMID:10597290
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P50539	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:Q9H8W4	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P01106	Human	PMID:16352593
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P01106	Human	PMID:16606833
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P01106	Human	PMID:17157259
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P01106	Human	PMID:17314511
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P01106	Human	PMID:17418410
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:Q05195	Human	PMID:17418410
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:Q99814	Human	PMID:17418410
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P04198	Human	PMID:18003922
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P01106	Human	PMID:18620061
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P02794	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:Q9UBS5	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P01106	Human	PMID:20691906
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P01106	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:Q8IWI9	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P01106	Human	PMID:21150319
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P01106	Human	PMID:21807113
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P01106	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:Q8IWI9	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P04198	Human	PMID:23792191
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P01106	Human	PMID:24951594
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:Q14186	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:Q8IWI9	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:Q969R5	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P04198	Human	PMID:25175806
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P50539	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:Q8N9N5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:Q9H3U1	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:O75367	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:O75461	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P01106	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P05549	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P18887	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P29692	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P49916	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P50539	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P51608	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:Q01167	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:Q14186	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:Q8IV63	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:Q8IWI9	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:Q969R5	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P01106	Human	PMID:26267534
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:O75461	Human	PMID:27705803
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P01106	Human	PMID:27705803
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P50539	Human	PMID:27705803
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:Q05195	Human	PMID:27705803
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:Q14186	Human	PMID:27705803
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:Q8IWI9	Human	PMID:27705803
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:Q969R5	Human	PMID:27705803
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P04198	Human	PMID:27728805
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:Q9H3U1	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P01106	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:Q9H8W4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAX	IPI	UniProtKB:P01106	Human	PMID:35140242
Molecular Function	GO:0005515	protein binding	Max	IPI	UniProtKB:P01108	Mouse	MGI:MGI:5142396|PMID:9764821
Molecular Function	GO:0005515	protein binding	Max	IPI	UniProtKB:Q99J95|UniProtKB:Q9QWV9	Mouse	MGI:MGI:4839428|PMID:20434984
Molecular Function	GO:0005515	protein binding	Max	IPI	UniProtKB:Q15327	Mouse	MGI:MGI:5294529|PMID:20599664
Molecular Function	GO:0005515	protein binding	Max	IPI	UniProtKB:P01108	Mouse	MGI:MGI:4889165|PMID:20946988
Molecular Function	GO:0005515	protein binding	Max	IPI	UniProtKB:P01108	Mouse	MGI:MGI:4839428|PMID:20434984
Molecular Function	GO:0005515	protein binding	Max	IPI	UniProtKB:P01108	Mouse	MGI:MGI:4455093|PMID:20211142
Molecular Function	GO:0005515	protein binding	Max	IPI	UniProtKB:P01106	Rat	PMID:11891322|RGD:8553449
Molecular Function	GO:0005515	protein binding	Max	IPI	UniProtKB:Q9QZM5	Rat	PMID:17304222|RGD:8553800
Molecular Function	GO:0005515	protein binding	max	IPI	ZFIN:ZDB-GENE-030603-1,ZFIN:ZDB-GENE-990603-8	Zfish	PMID:24525188
Molecular Function	GO:0044877	protein-containing complex binding	Max	IPI	RGD:3130	Rat	PMID:17341548|RGD:2290581
Molecular Function	GO:0044877	protein-containing complex binding	Max	IDA		Rat	PMID:18271930|RGD:2306213
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Max	IDA		Mouse	MGI:MGI:77472|PMID:8521822
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	MAX	IDA		Human	PMID:8425219
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	MAX	IDA		Human	PMID:8521822
Molecular Function	GO:0043565	sequence-specific DNA binding	Max	IDA		Rat	PMID:17341548|RGD:2290581
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	MAX	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	max	IDA		Zfish	PMID:24525188
Cellular Component	GO:0000785	chromatin	MAX	IDA		Human	PMID:12837246
Cellular Component	GO:0005737	cytoplasm	Max	IDA		Rat	PMID:14603520|RGD:2316820
Cellular Component	GO:0030425	dendrite	Max	IDA		Rat	PMID:14603520|RGD:2316820
Cellular Component	GO:0070443	Mad-Max complex	MAX	IPI		Human	PMID:12553908
Cellular Component	GO:0071339	MLL1 complex	MAX	IDA		Human	PMID:15960975
Cellular Component	GO:0071943	Myc-Max complex	MAX	IPI		Human	PMID:12553908
Cellular Component	GO:0071943	Myc-Max complex	Max	IPI		Mouse	MGI:MGI:4839428|PMID:20434984
Cellular Component	GO:0005634	nucleus	MAX	IDA		Human	PMID:15358760
Cellular Component	GO:0005634	nucleus	Max	IDA		Mouse	PMID:22770845
Cellular Component	GO:0005634	nucleus	Max	IDA		Rat	PMID:9130602|RGD:1599896
Cellular Component	GO:0016605	PML body	Max	IDA		Rat	PMID:15503302|RGD:2316819
Cellular Component	GO:0032993	protein-DNA complex	MAX	IMP		Human	PMID:16171389
Cellular Component	GO:0032993	protein-DNA complex	MAX	IDA		Human	PMID:9399572
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	MAX	IDA		Human	PMID:8425219
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	MAX	IDA		Human	PMID:8521822
Cellular Component	GO:0071141	SMAD protein complex	max	IPI	ZFIN:ZDB-GENE-030603-1,ZFIN:ZDB-GENE-990603-8	Zfish	PMID:24525188
Biological Process	GO:0071375	cellular response to peptide hormone stimulus	Max	IEP		Rat	PMID:10446908|RGD:2316822
Biological Process	GO:0009267	cellular response to starvation	Max	IEP		Rat	PMID:10446908|RGD:2316822
Biological Process	GO:0048264	determination of ventral identity	max	IMP	ZFIN:ZDB-MRPHLNO-110607-1	Zfish	PMID:24525188
Biological Process	GO:0048264	determination of ventral identity	max	IGI	ZFIN:ZDB-MRPHLNO-110607-1,ZFIN:ZDB-MRPHLNO-140701-1	Zfish	PMID:24525188
Biological Process	GO:0048264	determination of ventral identity	max	IGI	ZFIN:ZDB-MRPHLNO-110607-1,ZFIN:ZDB-MRPHLNO-140701-1,ZFIN:ZDB-MRPHLNO-140701-4	Zfish	PMID:24525188
Biological Process	GO:0009953	dorsal/ventral pattern formation	max	IDA		Zfish	PMID:22522081
Biological Process	GO:0009953	dorsal/ventral pattern formation	max	IMP	ZFIN:ZDB-MRPHLNO-110607-1	Zfish	PMID:22522081
Biological Process	GO:0030097	hemopoiesis	max	IMP	ZFIN:ZDB-MRPHLNO-110607-1	Zfish	PMID:21571218
Biological Process	GO:0010629	negative regulation of gene expression	Max	IDA		Rat	PMID:7791753|RGD:2316831
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	MAX	IDA		Human	PMID:8521822
Biological Process	GO:0051402	neuron apoptotic process	Max	IEP		Rat	PMID:14603520|RGD:2316820
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	MAX	IDA		Human	PMID:8425218
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Max	IDA		Mouse	MGI:MGI:4839428|PMID:20434984
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Max	IDA		Mouse	MGI:MGI:1351065|PMID:10601024
Biological Process	GO:0065003	protein-containing complex assembly	Max	IDA		Rat	PMID:18271930|RGD:2306213
Biological Process	GO:0006355	regulation of DNA-templated transcription	Max	IGI	MGI:MGI:97250	Mouse	PMID:8521822
Biological Process	GO:0006355	regulation of DNA-templated transcription	Max	IGI	MGI:MGI:104987	Mouse	PMID:8521822
Biological Process	GO:0006355	regulation of DNA-templated transcription	Max	IGI	MGI:MGI:104991	Mouse	PMID:8521822
Biological Process	GO:0006355	regulation of DNA-templated transcription	Max	IMP		Rat	PMID:17341548|RGD:2290581
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	MAX	IDA		Human	PMID:8425218
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Max	IDA		Mouse	MGI:MGI:77472|PMID:8521822
Biological Process	GO:0048678	response to axon injury	Max	IEP		Rat	PMID:14603520|RGD:2316820
Biological Process	GO:0032868	response to insulin	Max	IEP		Rat	PMID:10072196|RGD:2316824
Biological Process	GO:0010243	response to organonitrogen compound	Max	IEP		Rat	PMID:18271930|RGD:2306213
Biological Process	GO:0060041	retina development in camera-type eye	Max	IEP		Rat	PMID:14603520|RGD:2316820

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern