Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MBD2
  • Mouse genes Mbd2
  • Rat genes Mbd2
  • Zfish genes mbd2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mbd2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0070742	C2H2 zinc finger domain binding	MBD2	IPI	UniProtKB:Q9BQA5	Human	PMID:11553631
Molecular Function	GO:0003682	chromatin binding	Mbd2	IDA		Mouse	PMID:16608912
Molecular Function	GO:0003682	chromatin binding	Mbd2	IDA		Mouse	PMID:18644872
Molecular Function	GO:0003682	chromatin binding	Mbd2	IDA		Rat	PMID:25135974|RGD:9589119
Molecular Function	GO:0003677	DNA binding	Mbd2	IDA		Mouse	PMID:9774669
Molecular Function	GO:0008327	methyl-CpG binding	MBD2	IDA		Human	PMID:21029866
Molecular Function	GO:0008327	methyl-CpG binding	MBD2	IDA		Human	PMID:24307175
Molecular Function	GO:0008327	methyl-CpG binding	Mbd2	IDA		Mouse	PMID:15342650
Molecular Function	GO:0060090	molecular adaptor activity	MBD2	EXP		Human	PMID:25753662
Molecular Function	GO:0003729	mRNA binding	Mbd2	IDA		Mouse	PMID:15342650
Molecular Function	GO:0031492	nucleosomal DNA binding	MBD2	HDA		Human	PMID:16217013
Molecular Function	GO:0005515	protein binding	MBD2	IPI	UniProtKB:Q86YP4	Human	PMID:12183469
Molecular Function	GO:0005515	protein binding	MBD2	IPI	UniProtKB:Q86YP4	Human	PMID:16415179
Molecular Function	GO:0005515	protein binding	MBD2	IPI	UniProtKB:Q13547,UniProtKB:Q92769,UniProtKB:Q96ST3,UniProtKB:Q9NRA0	Human	PMID:19729656
Molecular Function	GO:0005515	protein binding	MBD2	IPI	UniProtKB:Q16637	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	MBD2	IPI	UniProtKB:Q86YP4	Human	PMID:25753662
Molecular Function	GO:0005515	protein binding	MBD2	IPI	UniProtKB:Q86YP4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MBD2	IPI	UniProtKB:Q96QR8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MBD2	IPI	UniProtKB:Q86YP4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Mbd2	IPI	PR:Q9QVP9	Mouse	PMID:24841674
Molecular Function	GO:0019904	protein domain specific binding	MBD2	IPI	UniProtKB:Q99698	Human	PMID:11984006
Molecular Function	GO:0035197	siRNA binding	Mbd2	IDA		Mouse	PMID:15342650
Cellular Component	GO:0000785	chromatin	MBD2	HDA		Human	PMID:16217013
Cellular Component	GO:0000785	chromatin	MBD2	IDA		Human	PMID:20523938
Cellular Component	GO:0000785	chromatin	MBD2	IDA		Human	PMID:23770133
Cellular Component	GO:0000785	chromatin	Mbd2	IDA		Mouse	PMID:9774669
Cellular Component	GO:0000785	chromatin	Mbd2	IDA		Rat	PMID:25135974|RGD:9589119
Cellular Component	GO:0005737	cytoplasm	Mbd2	IDA		Mouse	PMID:17546630
Cellular Component	GO:0005829	cytosol	MBD2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0000792	heterochromatin	Mbd2	IDA		Mouse	PMID:14519686
Cellular Component	GO:0000792	heterochromatin	Mbd2	IDA		Mouse	PMID:14643676
Cellular Component	GO:0000118	histone deacetylase complex	Mbd2	IDA		Mouse	PMID:11274056
Cellular Component	GO:0005654	nucleoplasm	MBD2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	MBD2	IDA		Human	PMID:11553631
Cellular Component	GO:0005634	nucleus	MBD2	IDA		Human	PMID:15701600
Cellular Component	GO:0005634	nucleus	MBD2	IDA		Human	PMID:20523938
Cellular Component	GO:0005634	nucleus	MBD2	IDA		Human	PMID:28977666
Cellular Component	GO:0005634	nucleus	MBD2	IDA		Human	PMID:33283408
Cellular Component	GO:0005634	nucleus	Mbd2	IDA		Mouse	PMID:17546630
Cellular Component	GO:0005634	nucleus	Mbd2	IDA		Mouse	PMID:9774669
Cellular Component	GO:0005634	nucleus	Mbd2	IDA		Mouse	PMID:11274056
Cellular Component	GO:0016581	NuRD complex	MBD2	IDA		Human	PMID:33283408
Cellular Component	GO:0032991	protein-containing complex	MBD2	HDA		Human	PMID:16217013
Biological Process	GO:0007568	aging	Mbd2	IEP		Rat	PMID:16702315|RGD:9588248
Biological Process	GO:0071407	cellular response to organic cyclic compound	Mbd2	IEP		Rat	PMID:25135974|RGD:9589119
Biological Process	GO:0006338	chromatin remodeling	MBD2	HDA		Human	PMID:16217013
Biological Process	GO:0006338	chromatin remodeling	MBD2	IDA		Human	PMID:16428440
Biological Process	GO:0006338	chromatin remodeling	MBD2	IDA		Human	PMID:9790534
Biological Process	GO:0006346	DNA methylation-dependent heterochromatin formation	MBD2	IGI	UniProtKB:Q13547	Human	PMID:23770133
Biological Process	GO:0048568	embryonic organ development	Mbd2	IEP		Rat	PMID:12672019|RGD:9587841
Biological Process	GO:0007507	heart development	Mbd2	IEP		Rat	PMID:20735989|RGD:9588647
Biological Process	GO:0016575	histone deacetylation	MBD2	IDA		Human	PMID:10444591
Biological Process	GO:0042711	maternal behavior	Mbd2	IMP	MGI:MGI:2388002	Mouse	PMID:11274056
Biological Process	GO:0042711	maternal behavior	Mbd2	IEP		Rat	PMID:25135974|RGD:9589119
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	MBD2	IGI	UniProtKB:Q13547	Human	PMID:23770133
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Mbd2	IMP	MGI:MGI:2388002	Mouse	PMID:11274056
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Mbd2	IMP	MGI:MGI:2388002	Mouse	PMID:18644872
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Mbd2	IMP	MGI:MGI:2388002	Mouse	PMID:11242117
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Mbd2	IMP		Rat	PMID:25135974|RGD:9589119
Biological Process	GO:0035563	positive regulation of chromatin binding	Mbd2	IMP		Rat	PMID:25135974|RGD:9589119
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	Mbd2	IGI	MGI:MGI:88039	Mouse	PMID:18644872
Biological Process	GO:0065003	protein-containing complex assembly	Mbd2	IMP	MGI:MGI:2388002	Mouse	PMID:11274056
Biological Process	GO:0042127	regulation of cell population proliferation	Mbd2	IGI	MGI:MGI:88039	Mouse	PMID:18644872
Biological Process	GO:0044030	regulation of DNA methylation	Mbd2	IEP		Rat	PMID:20735989|RGD:9588647
Biological Process	GO:0032355	response to estradiol	Mbd2	IEP		Rat	PMID:22109888|RGD:9588666
Biological Process	GO:0009612	response to mechanical stimulus	Mbd2	IEP		Rat	PMID:25135974|RGD:9589119
Biological Process	GO:0031667	response to nutrient levels	Mbd2	IEP		Rat	PMID:16702315|RGD:9588248
Biological Process	GO:0014070	response to organic cyclic compound	Mbd2	IEP		Rat	PMID:22109888|RGD:9588666
Biological Process	GO:0016055	Wnt signaling pathway	Mbd2	IGI	MGI:MGI:88039	Mouse	PMID:18644872

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern