Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MBD3
  • Mouse genes Mbd3
  • Rat genes Mbd3
  • Zfish genes mbd3a,mbd3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mbd3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Mbd3	IDA		Mouse	PMID:16322236
Molecular Function	GO:0003677	DNA binding	Mbd3	IDA		Mouse	PMID:9774669
Molecular Function	GO:0008327	methyl-CpG binding	MBD3	IDA		Human	PMID:24307175
Molecular Function	GO:0031492	nucleosomal DNA binding	MBD3	HDA		Human	PMID:16217013
Molecular Function	GO:0005515	protein binding	MBD3	IPI	UniProtKB:Q86YP4	Human	PMID:12183469
Molecular Function	GO:0005515	protein binding	MBD3	IPI	UniProtKB:O60341	Human	PMID:19703393
Molecular Function	GO:0005515	protein binding	MBD3	IPI	UniProtKB:P17844	Human	PMID:20676135
Molecular Function	GO:0005515	protein binding	MBD3	IPI	UniProtKB:Q13547	Human	PMID:21258344
Molecular Function	GO:0005515	protein binding	MBD3	IPI	UniProtKB:O60341	Human	PMID:23455924
Molecular Function	GO:0005515	protein binding	MBD3	IPI	UniProtKB:Q13547	Human	PMID:23752268
Molecular Function	GO:0005515	protein binding	MBD3	IPI	UniProtKB:O43474	Human	PMID:24048479
Molecular Function	GO:0005515	protein binding	MBD3	IPI	UniProtKB:P01106	Human	PMID:24048479
Molecular Function	GO:0005515	protein binding	MBD3	IPI	UniProtKB:P48431	Human	PMID:24048479
Molecular Function	GO:0005515	protein binding	MBD3	IPI	UniProtKB:Q01860	Human	PMID:24048479
Molecular Function	GO:0005515	protein binding	MBD3	IPI	UniProtKB:Q13547	Human	PMID:24048479
Molecular Function	GO:0005515	protein binding	MBD3	IPI	UniProtKB:Q13547	Human	PMID:25123934
Molecular Function	GO:0005515	protein binding	MBD3	IPI	UniProtKB:Q8WXI9	Human	PMID:25123934
Molecular Function	GO:0005515	protein binding	MBD3	IPI	UniProtKB:O00560	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MBD3	IPI	UniProtKB:P19012	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MBD3	IPI	UniProtKB:Q05084	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MBD3	IPI	UniProtKB:Q08379	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MBD3	IPI	UniProtKB:Q8TAP6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MBD3	IPI	UniProtKB:Q8WWA6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MBD3	IPI	UniProtKB:Q8WXI9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MBD3	IPI	UniProtKB:Q96D15	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MBD3	IPI	UniProtKB:Q9BYV2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MBD3	IPI	UniProtKB:Q13547	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	Mbd3	IPI	UniProtKB:P14404	Mouse	MGI:MGI:3805072|PMID:18500823
Molecular Function	GO:0005515	protein binding	Mbd3	IPI	PR:Q9R190	Mouse	PMID:16462733
Molecular Function	GO:0005515	protein binding	Mbd3	IPI	PR:P59178	Mouse	PMID:22770845
Molecular Function	GO:0005515	protein binding	Mbd3	IPI	PR:Q8K4B0	Mouse	PMID:16462733
Molecular Function	GO:0005515	protein binding	Mbd3	IPI	PR:Q3TKT4	Mouse	PMID:16322236
Molecular Function	GO:0005515	protein binding	Mbd3	IPI	PR:O09106	Mouse	PMID:16462733
Cellular Component	GO:0000785	chromatin	MBD3	HDA		Human	PMID:16217013
Cellular Component	GO:0000785	chromatin	Mbd3	IDA		Mouse	PMID:9774669
Cellular Component	GO:0005737	cytoplasm	Mbd3	IDA		Mouse	PMID:17546630
Cellular Component	GO:0000792	heterochromatin	Mbd3	IDA		Mouse	PMID:14643676
Cellular Component	GO:0000792	heterochromatin	Mbd3	IDA		Mouse	PMID:16322236
Cellular Component	GO:0005634	nucleus	MBD3	IDA		Human	PMID:15701600
Cellular Component	GO:0005634	nucleus	MBD3	IDA		Human	PMID:20523938
Cellular Component	GO:0005634	nucleus	MBD3	IDA		Human	PMID:28977666
Cellular Component	GO:0005634	nucleus	MBD3	IDA		Human	PMID:33283408
Cellular Component	GO:0005634	nucleus	Mbd3	IDA		Mouse	PMID:14643676
Cellular Component	GO:0005634	nucleus	Mbd3	IDA		Mouse	PMID:20720167
Cellular Component	GO:0005634	nucleus	Mbd3	IDA		Mouse	PMID:17546630
Cellular Component	GO:0005634	nucleus	Mbd3	IDA		Mouse	PMID:9774669
Cellular Component	GO:0005634	nucleus	Mbd3	IDA		Mouse	PMID:17287250
Cellular Component	GO:0005634	nucleus	Mbd3	IDA		Mouse	PMID:22770845
Cellular Component	GO:0016581	NuRD complex	MBD3	IDA		Human	PMID:33283408
Cellular Component	GO:0016581	NuRD complex	Mbd3	IPI	PR:Q9R190	Mouse	PMID:16462733
Cellular Component	GO:0016581	NuRD complex	Mbd3	IPI	PR:O09106	Mouse	PMID:16462733
Cellular Component	GO:0016581	NuRD complex	Mbd3	IPI	PR:Q8K4B0	Mouse	PMID:16462733
Cellular Component	GO:0032991	protein-containing complex	MBD3	HDA		Human	PMID:16217013
Cellular Component	GO:0032991	protein-containing complex	Mbd3	IDA		Mouse	PMID:19796622
Biological Process	GO:0007568	aging	Mbd3	IEP		Rat	PMID:16702315|RGD:9588248
Biological Process	GO:0007420	brain development	Mbd3	IEP		Rat	PMID:12672019|RGD:9587841
Biological Process	GO:0006338	chromatin remodeling	MBD3	HDA		Human	PMID:16217013
Biological Process	GO:0006338	chromatin remodeling	MBD3	IDA		Human	PMID:16428440
Biological Process	GO:0006338	chromatin remodeling	MBD3	IDA		Human	PMID:9790534
Biological Process	GO:0060271	cilium assembly	mbd3b	IMP	ZFIN:ZDB-MRPHLNO-200323-12	Zfish	PMID:31513014
Biological Process	GO:0060216	definitive hemopoiesis	mbd3b	IMP	ZFIN:ZDB-MRPHLNO-141017-4	Zfish	PMID:24240475
Biological Process	GO:0061371	determination of heart left/right asymmetry	mbd3a	IMP	ZFIN:ZDB-MRPHLNO-141017-3	Zfish	PMID:31513014
Biological Process	GO:0061371	determination of heart left/right asymmetry	mbd3b	IMP	ZFIN:ZDB-MRPHLNO-200323-12	Zfish	PMID:31513014
Biological Process	GO:0006346	DNA methylation-dependent heterochromatin formation	Mbd3	IDA		Mouse	PMID:16322236
Biological Process	GO:0048568	embryonic organ development	Mbd3	IEP		Rat	PMID:12672019|RGD:9587841
Biological Process	GO:0007507	heart development	Mbd3	IEP		Rat	PMID:20735989|RGD:9588647
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	mbd3b	IMP		Zfish	PMID:24240475
Biological Process	GO:0016573	histone acetylation	Mbd3	IMP	MGI:MGI:2388006	Mouse	PMID:16462733
Biological Process	GO:0016575	histone deacetylation	MBD3	IDA		Human	PMID:10444591
Biological Process	GO:0001701	in utero embryonic development	Mbd3	IMP	MGI:MGI:2388006	Mouse	PMID:17287250
Biological Process	GO:0070121	Kupffer's vesicle development	mbd3b	IMP	ZFIN:ZDB-MRPHLNO-200323-12	Zfish	PMID:31513014
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Mbd3	IDA		Mouse	PMID:16322236
Biological Process	GO:0044030	regulation of DNA methylation	Mbd3	IEP		Rat	PMID:20735989|RGD:9588647
Biological Process	GO:0032355	response to estradiol	Mbd3	IEP		Rat	PMID:22109888|RGD:9588666
Biological Process	GO:0031667	response to nutrient levels	Mbd3	IEP		Rat	PMID:16702315|RGD:9588248
Biological Process	GO:0014070	response to organic cyclic compound	Mbd3	IEP		Rat	PMID:22109888|RGD:9588666
Biological Process	GO:0009888	tissue development	Mbd3	IMP	MGI:MGI:2388006	Mouse	PMID:17287250

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern