Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MBL2
  • Mouse genes Mbl2
  • Rat genes Mbl2
  • Zfish genes hbl1,hbl2,hbl4,mbl2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mbl2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	Mbl2	IDA		Rat	PMID:9922166|RGD:6903270
Molecular Function	GO:0048306	calcium-dependent protein binding	MBL2	IPI	UniProtKB:O00187	Human	PMID:12421953
Molecular Function	GO:0048306	calcium-dependent protein binding	MBL2	IPI	UniProtKB:P48740	Human	PMID:12421953
Molecular Function	GO:0048306	calcium-dependent protein binding	MBL2	IPI	UniProtKB:P48740	Human	PMID:18596036
Molecular Function	GO:0048306	calcium-dependent protein binding	MBL2	IPI	UniProtKB:P0DTC2	Human	PMID:35102342
Molecular Function	GO:0005534	galactose binding	Mbl2	IDA		Rat	PMID:8557671|RGD:6903273
Molecular Function	GO:0042802	identical protein binding	MBL2	IPI	UniProtKB:P11226	Human	PMID:21106539
Molecular Function	GO:0042802	identical protein binding	MBL2	IPI	UniProtKB:P11226	Human	PMID:21383675
Molecular Function	GO:0042802	identical protein binding	MBL2	IPI	UniProtKB:P11226	Human	PMID:22607836
Molecular Function	GO:0042802	identical protein binding	MBL2	IPI	UniProtKB:P11226	Human	PMID:25579818
Molecular Function	GO:0042802	identical protein binding	MBL2	IPI	UniProtKB:P11226	Human	PMID:27104295
Molecular Function	GO:0042802	identical protein binding	Mbl2	IPI	RGD:67380	Rat	PMID:20118239|RGD:7242176
Molecular Function	GO:0042802	identical protein binding	Mbl2	IPI	RGD:67380	Rat	PMID:9230118|RGD:1582157
Molecular Function	GO:0005537	mannose binding	MBL2	IDA		Human	PMID:23544079
Molecular Function	GO:0005537	mannose binding	Mbl2	IDA		Rat	PMID:10589993|RGD:1582160
Molecular Function	GO:0070273	phosphatidylinositol-4-phosphate binding	Mbl2	IDA		Rat	PMID:9315725|RGD:6903277
Molecular Function	GO:0002020	protease binding	Mbl2	IPI	RGD:620213|RGD:620214	Rat	PMID:11337510|RGD:4889149
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:O00187	Human	PMID:11290788
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:O00187-2	Human	PMID:11290788
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:O00187:PRO_0000027598	Human	PMID:11290788
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:P48740:PRO_0000027592	Human	PMID:11290788
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:P48740-2	Human	PMID:11485744
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:O00187-2	Human	PMID:15117939
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:O00187-2	Human	PMID:18177377
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:O00187:PRO_0000027598	Human	PMID:18177377
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:P27797	Human	PMID:18177377
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:P48740-2	Human	PMID:18177377
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:P48740-2	Human	PMID:19939495
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:P48740	Human	PMID:20956340
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:P48740-3	Human	PMID:21035894
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:Q07954	Human	PMID:21054788
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:P02743	Human	PMID:21106539
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:P27958:PRO_0000037570	Human	PMID:21203938
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:P10124	Human	PMID:21268013
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:O00206	Human	PMID:21383675
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:O00187-2	Human	PMID:22607836
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:P48740	Human	PMID:22607836
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:P48740-2	Human	PMID:22607836
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:Q9UGM3	Human	PMID:22811680
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:P48740-2	Human	PMID:22854970
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:P48740-3	Human	PMID:22854970
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:P17927	Human	PMID:23460739
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:P48740-1	Human	PMID:25579818
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:O00187	Human	PMID:27104295
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:P48740-1	Human	PMID:27104295
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:P48740-2	Human	PMID:27104295
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:P48740-3	Human	PMID:27104295
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:P17927	Human	PMID:29563915
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:P48740-1	Human	PMID:32041782
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:P48740-2	Human	PMID:32041782
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:P48740-3	Human	PMID:32041782
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:Q9UHD9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MBL2	IPI	UniProtKB:P02749	Human	PMID:32759297
Molecular Function	GO:0043621	protein self-association	Mbl2	IDA		Rat	PMID:8557671|RGD:6903273
Molecular Function	GO:0005102	signaling receptor binding	MBL2	IPI	UniProtKB:P04264	Human	PMID:11549596
Cellular Component	GO:0005615	extracellular space	MBL2	IDA		Human	PMID:23544079
Cellular Component	GO:0005615	extracellular space	Mbl2	IDA		Mouse	PMID:15148336
Cellular Component	GO:0005615	extracellular space	Mbl2	IDA		Rat	PMID:3124748|RGD:4889498
Cellular Component	GO:0032991	protein-containing complex	Mbl2	IMP		Rat	PMID:9920905|RGD:4889148
Cellular Component	GO:1905370	serine-type endopeptidase complex	MBL2	IPI		Human	PMID:25579818
Biological Process	GO:0140374	antiviral innate immune response	MBL2	IDA		Human	PMID:35102342
Biological Process	GO:0002752	cell surface pattern recognition receptor signaling pathway	MBL2	IDA		Human	PMID:22966085
Biological Process	GO:0001867	complement activation, lectin pathway	MBL2	IDA		Human	PMID:15148336
Biological Process	GO:0001867	complement activation, lectin pathway	MBL2	IPI	UniProtKB:P04264	Human	PMID:11549596
Biological Process	GO:0001867	complement activation, lectin pathway	MBL2	IDA		Human	PMID:22691502
Biological Process	GO:0001867	complement activation, lectin pathway	MBL2	IDA		Human	PMID:35102342
Biological Process	GO:0001867	complement activation, lectin pathway	Mbl2	IMP	MGI:MGI:3577339	Mouse	PMID:15148336
Biological Process	GO:0001867	complement activation, lectin pathway	Mbl2	IDA		Mouse	PMID:15148336
Biological Process	GO:0001867	complement activation, lectin pathway	Mbl2	IGI	MGI:MGI:96923	Mouse	PMID:15148336
Biological Process	GO:0050830	defense response to Gram-positive bacterium	MBL2	IDA		Human	PMID:15148336
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Mbl2	IGI	MGI:MGI:96923	Mouse	PMID:15148336
Biological Process	GO:0045087	innate immune response	MBL2	IDA		Human	PMID:23544079
Biological Process	GO:0051873	killing by host of symbiont cells	Mbl2	IGI	MGI:MGI:96923	Mouse	PMID:15148336
Biological Process	GO:0048525	negative regulation of viral process	MBL2	IDA		Human	PMID:23544079
Biological Process	GO:0045917	positive regulation of complement activation	Mbl2	IDA		Rat	PMID:9920905|RGD:4889148
Biological Process	GO:1903028	positive regulation of opsonization	MBL2	IDA		Human	PMID:22966085
Biological Process	GO:0050766	positive regulation of phagocytosis	Mbl2	IGI	MGI:MGI:96923	Mouse	PMID:15148336
Biological Process	GO:0010954	positive regulation of protein processing	Mbl2	IDA		Rat	PMID:20118239|RGD:7242176
Biological Process	GO:0006508	proteolysis	MBL2	IDA		Human	PMID:22691502

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern