Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MC5R
  • Mouse genes Mc5r
  • Rat genes Mc5r
  • Zfish genes mc5ra,mc5rb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mc5r

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042562	hormone binding	Mc5r	IMP		Rat	PMID:16454799|RGD:1626221
Molecular Function	GO:0042562	hormone binding	Mc5r	IDA		Rat	PMID:8179577|RGD:729030
Molecular Function	GO:0004977	melanocortin receptor activity	Mc5r	IMP		Rat	PMID:16454799|RGD:1626221
Molecular Function	GO:0004977	melanocortin receptor activity	Mc5r	IDA		Rat	PMID:8179577|RGD:729030
Molecular Function	GO:0005515	protein binding	MC5R	IPI	UniProtKB:Q8TCY5	Human	PMID:19329486
Molecular Function	GO:0005515	protein binding	MC5R	IPI	UniProtKB:Q96G30	Human	PMID:19329486
Molecular Function	GO:0046982	protein heterodimerization activity	mc5ra	IDA		Zfish	PMID:30400043
Molecular Function	GO:0046982	protein heterodimerization activity	mc5rb	IDA		Zfish	PMID:30400043
Cellular Component	GO:0005886	plasma membrane	MC5R	IDA		Human	GO_REF:0000052
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	MC5R	IDA		Human	PMID:19329486

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern