Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Mcl1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes MCL1
- Mouse genes Mcl1
- Rat genes Mcl1
- Zfish genes mcl1a,mcl1b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mcl1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051400	BH domain binding	Mcl1	IPI	RGD:2192	Rat	PMID:9356461\|RGD:70678
Molecular Function	GO:0051400	BH domain binding	Mcl1	IPI	RGD:621547	Rat	PMID:9356461\|RGD:70678
Molecular Function	GO:0051400	BH domain binding	Mcl1	IPI	RGD:621635	Rat	PMID:9356461\|RGD:70678
Molecular Function	GO:0051400	BH domain binding	Mcl1	IPI	RGD:70984	Rat	PMID:9356461\|RGD:70678
Molecular Function	GO:0051434	BH3 domain binding	MCL1	IPI	UniProtKB:P55957	Human	PMID:21036904
Molecular Function	GO:0051434	BH3 domain binding	MCL1	IPI	UniProtKB:Q16611	Human	PMID:21036904
Molecular Function	GO:0051434	BH3 domain binding	Mcl1	IPI	UniProtKB:Q16611	Mouse	MGI:MGI:3689797\|PMID:15901672
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q13794	Human	PMID:15901672
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q16611	Human	PMID:15901672
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:O43521	Human	PMID:16697956
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:P55957	Human	PMID:16697956
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q9BXH1	Human	PMID:16697956
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q9JM54	Human	PMID:16697956
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q16611	Human	PMID:17097560
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:P59635	Human	PMID:17428862
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:O43521	Human	PMID:17525735
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q07812	Human	PMID:17525735
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q16611	Human	PMID:18040043
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q07812	Human	PMID:18981409
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:P55957	Human	PMID:19074266
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q91AU0	Human	PMID:19605477
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q07812	Human	PMID:19968986
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q16611	Human	PMID:19968986
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q16611	Human	PMID:20023629
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q7Z6Z7	Human	PMID:20023629
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q93008	Human	PMID:20023629
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:O43521	Human	PMID:20085765
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q13794	Human	PMID:20085765
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:O43521	Human	PMID:21132008
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q13794	Human	PMID:21132008
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q16611	Human	PMID:21132008
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q14457	Human	PMID:21139567
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:O43521	Human	PMID:21199865
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q07812	Human	PMID:21199865
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q13794	Human	PMID:21454712
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q07812	Human	PMID:21458670
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:O43521	Human	PMID:21507240
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q7Z6Z7	Human	PMID:21507240
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:P49817	Human	PMID:22277751
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q03135	Human	PMID:22277751
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:O43521	Human	PMID:22516262
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q16611	Human	PMID:22516262
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q9BXH1	Human	PMID:22516262
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q7L3V2	Human	PMID:23055042
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:O43521	Human	PMID:23245996
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q16611	Human	PMID:23680104
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q14457	Human	PMID:24113155
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q9BXH1	Human	PMID:26431330
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q9BXH1-2	Human	PMID:26431330
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:O43521	Human	PMID:26859456
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:O54918	Human	PMID:27013495
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q16611	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q9BXH1	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q16611	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q96LC9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q9H3M0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MCL1	IPI	UniProtKB:Q9UNK0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Mcl1	IPI	UniProtKB:O54918	Mouse	MGI:MGI:5514334\|PMID:16543145
Molecular Function	GO:0005515	protein binding	Mcl1	IPI	UniProtKB:O43521\|UniProtKB:O54918\|UniProtKB:Q9BXH1\|UniProtKB:Q9JM54	Mouse	MGI:MGI:3689775\|PMID:15694340
Molecular Function	GO:0005515	protein binding	Mcl1	IPI	UniProtKB:Q16611	Mouse	MGI:MGI:3689797\|PMID:15901672
Molecular Function	GO:0005515	protein binding	Mcl1	IPI	UniProtKB:O43521\|UniProtKB:Q9BXH1\|UniProtKB:Q9JM54	Mouse	MGI:MGI:4822083\|PMID:20627101
Molecular Function	GO:0005515	protein binding	Mcl1	IPI	UniProtKB:O43521\|UniProtKB:O54918\|UniProtKB:Q07812	Mouse	MGI:MGI:5315340\|PMID:17289999
Molecular Function	GO:0005515	protein binding	Mcl1	IPI	UniProtKB:O54918	Mouse	MGI:MGI:5315677\|PMID:20921992
Molecular Function	GO:0005515	protein binding	Mcl1	IPI	UniProtKB:O08734	Mouse	MGI:MGI:5009775\|PMID:21041309
Molecular Function	GO:0005515	protein binding	Mcl1	IPI	UniProtKB:O08734	Mouse	MGI:MGI:5796067\|PMID:26949185
Molecular Function	GO:0005515	protein binding	Mcl1	IPI	UniProtKB:O08734\|UniProtKB:O54918\|UniProtKB:Q99ML1\|UniProtKB:Q9JM54	Mouse	MGI:MGI:4939122\|PMID:18589438
Molecular Function	GO:0005515	protein binding	Mcl1	IPI	UniProtKB:Q0VBL6	Mouse	MGI:MGI:5526927\|PMID:21546903
Molecular Function	GO:0005515	protein binding	Mcl1	IPI	UniProtKB:Q9JM54	Mouse	MGI:MGI:6093095\|PMID:17389404
Molecular Function	GO:0005515	protein binding	Mcl1	IPI	RGD:620103	Rat	PMID:10579309\|RGD:633263
Molecular Function	GO:0005515	protein binding	Mcl1	IPI	RGD:628774	Rat	PMID:10579309\|RGD:633263
Molecular Function	GO:0005515	protein binding	Mcl1	IPI	UniProtKB:Q792S6	Rat	PMID:9356461\|RGD:70678
Molecular Function	GO:0046983	protein dimerization activity	Mcl1	IPI	UniProtKB:Q792S6	Rat	PMID:9356461\|RGD:70678
Molecular Function	GO:0046982	protein heterodimerization activity	MCL1	IPI	UniProtKB:P04637	Human	PMID:10837489
Molecular Function	GO:0046982	protein heterodimerization activity	MCL1	IPI	UniProtKB:Q16611	Human	PMID:10837489
Molecular Function	GO:0046982	protein heterodimerization activity	mcl1a	IPI	ZFIN:ZDB-GENE-070119-3	Zfish	PMID:24608793
Molecular Function	GO:0046982	protein heterodimerization activity	mcl1b	IPI	ZFIN:ZDB-GENE-070119-3	Zfish	PMID:24608793
Molecular Function	GO:0044877	protein-containing complex binding	Mcl1	IPI	RGD:2192	Rat	PMID:9356461\|RGD:70678
Molecular Function	GO:0044877	protein-containing complex binding	Mcl1	IPI	RGD:621547	Rat	PMID:9356461\|RGD:70678
Molecular Function	GO:0044877	protein-containing complex binding	Mcl1	IPI	RGD:621635	Rat	PMID:9356461\|RGD:70678
Molecular Function	GO:0044877	protein-containing complex binding	Mcl1	IPI	RGD:70984	Rat	PMID:9356461\|RGD:70678
Cellular Component	GO:0097136	Bcl-2 family protein complex	MCL1	IPI		Human	PMID:21132008
Cellular Component	GO:0097136	Bcl-2 family protein complex	MCL1	IDA		Human	PMID:21199865
Cellular Component	GO:0005737	cytoplasm	Mcl1	IDA		Mouse	PMID:20467439
Cellular Component	GO:0005829	cytosol	Mcl1	IDA		Mouse	MGI:MGI:5514334\|PMID:16543145
Cellular Component	GO:0016020	membrane	MCL1	IDA		Human	PMID:7896880
Cellular Component	GO:0016020	membrane	Mcl1	IDA		Mouse	MGI:MGI:5514334\|PMID:16543145
Cellular Component	GO:0005739	mitochondrion	MCL1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	MCL1	IDA		Human	PMID:7896880
Cellular Component	GO:0005739	mitochondrion	Mcl1	IDA		Mouse	MGI:MGI:5543313\|PMID:23858059
Cellular Component	GO:0005739	mitochondrion	Mcl1	IDA		Mouse	PMID:23926254
Cellular Component	GO:0005634	nucleus	MCL1	IDA		Human	PMID:20467439
Cellular Component	GO:0005634	nucleus	Mcl1	IDA		Mouse	PMID:20467439
Biological Process	GO:0043009	chordate embryonic development	mcl1a	IGI	ZFIN:ZDB-MRPHLNO-070125-1,ZFIN:ZDB-MRPHLNO-070125-2	Zfish	PMID:16888646
Biological Process	GO:0043009	chordate embryonic development	mcl1b	IGI	ZFIN:ZDB-MRPHLNO-070125-1,ZFIN:ZDB-MRPHLNO-070125-2	Zfish	PMID:16888646
Biological Process	GO:0006974	DNA damage response	MCL1	IMP		Human	PMID:20467439
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	MCL1	IMP		Human	PMID:16543145
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	Mcl1	IMP		Mouse	MGI:MGI:5514334\|PMID:16543145
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	Mcl1	IDA		Mouse	PMID:15901672
Biological Process	GO:2000811	negative regulation of anoikis	MCL1	IMP		Human	PMID:22277751
Biological Process	GO:0043066	negative regulation of apoptotic process	MCL1	IDA		Human	PMID:20041405
Biological Process	GO:0043066	negative regulation of apoptotic process	Mcl1	IMP		Mouse	MGI:MGI:5315340\|PMID:17289999
Biological Process	GO:0043066	negative regulation of apoptotic process	Mcl1	IDA		Rat	PMID:9356461\|RGD:70678
Biological Process	GO:0043066	negative regulation of apoptotic process	mcl1a	IGI	ZFIN:ZDB-GENE-070119-3	Zfish	PMID:16888646
Biological Process	GO:0043066	negative regulation of apoptotic process	mcl1a	IGI	ZFIN:ZDB-GENE-000511-6	Zfish	PMID:16888646
Biological Process	GO:0043066	negative regulation of apoptotic process	mcl1a	IGI	ZFIN:ZDB-MRPHLNO-070125-1,ZFIN:ZDB-MRPHLNO-070125-2	Zfish	PMID:24608793
Biological Process	GO:0043066	negative regulation of apoptotic process	mcl1a	IGI	ZFIN:ZDB-GENE-041210-319	Zfish	PMID:16888646
Biological Process	GO:0043066	negative regulation of apoptotic process	mcl1a	IGI	ZFIN:ZDB-GENE-041210-181	Zfish	PMID:16888646
Biological Process	GO:0043066	negative regulation of apoptotic process	mcl1a	IGI	ZFIN:ZDB-GENE-070119-4	Zfish	PMID:16888646
Biological Process	GO:0043066	negative regulation of apoptotic process	mcl1a	IGI	ZFIN:ZDB-GENE-050227-21	Zfish	PMID:16888646
Biological Process	GO:0043066	negative regulation of apoptotic process	mcl1a	IGI	ZFIN:ZDB-MRPHLNO-070125-1,ZFIN:ZDB-MRPHLNO-070125-2	Zfish	PMID:16888646
Biological Process	GO:0043066	negative regulation of apoptotic process	mcl1a	IGI	ZFIN:ZDB-GENE-070119-1	Zfish	PMID:16888646
Biological Process	GO:0043066	negative regulation of apoptotic process	mcl1a	IGI	ZFIN:ZDB-GENE-050419-35	Zfish	PMID:16888646
Biological Process	GO:0043066	negative regulation of apoptotic process	mcl1b	IGI	ZFIN:ZDB-GENE-070119-4	Zfish	PMID:16888646
Biological Process	GO:0043066	negative regulation of apoptotic process	mcl1b	IGI	ZFIN:ZDB-GENE-050227-21	Zfish	PMID:16888646
Biological Process	GO:0043066	negative regulation of apoptotic process	mcl1b	IGI	ZFIN:ZDB-GENE-000511-6	Zfish	PMID:16888646
Biological Process	GO:0043066	negative regulation of apoptotic process	mcl1b	IGI	ZFIN:ZDB-GENE-070119-1	Zfish	PMID:16888646
Biological Process	GO:0043066	negative regulation of apoptotic process	mcl1b	IGI	ZFIN:ZDB-MRPHLNO-070125-1,ZFIN:ZDB-MRPHLNO-070125-2	Zfish	PMID:24608793
Biological Process	GO:0043066	negative regulation of apoptotic process	mcl1b	IGI	ZFIN:ZDB-GENE-041210-319	Zfish	PMID:16888646
Biological Process	GO:0043066	negative regulation of apoptotic process	mcl1b	IGI	ZFIN:ZDB-GENE-050419-35	Zfish	PMID:16888646
Biological Process	GO:0043066	negative regulation of apoptotic process	mcl1b	IGI	ZFIN:ZDB-GENE-041210-181	Zfish	PMID:16888646
Biological Process	GO:0043066	negative regulation of apoptotic process	mcl1b	IGI	ZFIN:ZDB-MRPHLNO-070125-1,ZFIN:ZDB-MRPHLNO-070125-2	Zfish	PMID:16888646
Biological Process	GO:0043066	negative regulation of apoptotic process	mcl1b	IGI	ZFIN:ZDB-GENE-070119-3	Zfish	PMID:16888646
Biological Process	GO:0010507	negative regulation of autophagy	MCL1	IMP		Human	PMID:24113155
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	mcl1a	IDA		Zfish	PMID:16888646
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	mcl1b	IDA		Zfish	PMID:16888646
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	MCL1	IMP		Human	PMID:20921992
Biological Process	GO:0045839	negative regulation of mitotic nuclear division	mcl1a	IGI	ZFIN:ZDB-MRPHLNO-070125-1,ZFIN:ZDB-MRPHLNO-070125-2	Zfish	PMID:24608793
Biological Process	GO:0045839	negative regulation of mitotic nuclear division	mcl1b	IGI	ZFIN:ZDB-MRPHLNO-070125-1,ZFIN:ZDB-MRPHLNO-070125-2	Zfish	PMID:24608793
Biological Process	GO:0043065	positive regulation of apoptotic process	MCL1	IDA		Human	PMID:21132008
Biological Process	GO:1903378	positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	MCL1	IGI	UniProtKB:Q9WVS6	Human	PMID:23858059
Biological Process	GO:1903378	positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	Mcl1	IMP		Mouse	MGI:MGI:5543313\|PMID:23858059
Biological Process	GO:0042981	regulation of apoptotic process	mcl1a	IGI	ZFIN:ZDB-GENE-030825-1,ZFIN:ZDB-GENE-070119-3	Zfish	PMID:24608793
Biological Process	GO:0042981	regulation of apoptotic process	mcl1b	IGI	ZFIN:ZDB-GENE-000511-7,ZFIN:ZDB-GENE-070119-3	Zfish	PMID:24608793
Biological Process	GO:0007088	regulation of mitotic nuclear division	mcl1a	IGI	ZFIN:ZDB-GENE-030825-1,ZFIN:ZDB-GENE-070119-3	Zfish	PMID:24608793
Biological Process	GO:0007088	regulation of mitotic nuclear division	mcl1b	IGI	ZFIN:ZDB-GENE-000511-7,ZFIN:ZDB-GENE-070119-3	Zfish	PMID:24608793
Biological Process	GO:0034097	response to cytokine	MCL1	IDA		Human	PMID:9184696
Biological Process	GO:0001894	tissue homeostasis	mcl1a	IMP		Zfish	PMID:16273521

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 07/02/2024 MGI 6.13

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.