Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MCM2
  • Mouse genes Mcm2
  • Rat genes Mcm2
  • Zfish genes mcm2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mcm2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	mcm2	IDA		Zfish	PMID:18974873
Molecular Function	GO:0003688	DNA replication origin binding	Mcm2	IDA		Mouse	PMID:12941272
Molecular Function	GO:0019899	enzyme binding	Mcm2	IPI	UniProtKB:Q0VGM9	Mouse	MGI:MGI:5522574|PMID:24115439
Molecular Function	GO:0042393	histone binding	Mcm2	IDA		Mouse	PMID:10531422
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:Q7L590	Human	PMID:11095689
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:O43823	Human	PMID:12740381
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:P25205	Human	PMID:15232106
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:P33992	Human	PMID:15232106
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:P33993	Human	PMID:15232106
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:P53350	Human	PMID:15654075
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:Q14566	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:O95251	Human	PMID:16387653
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:P25205	Human	PMID:16899510
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:P33992	Human	PMID:16899510
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:P33993	Human	PMID:16899510
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:Q14566	Human	PMID:16899510
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:Q08945	Human	PMID:16902406
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:P25205	Human	PMID:17296731
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:P33992	Human	PMID:17296731
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:P33993	Human	PMID:17296731
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:Q14566	Human	PMID:17296731
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:O75419	Human	PMID:19805216
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:Q96H20	Human	PMID:19819239
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:P62805	Human	PMID:19862764
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:Q14566	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:Q9NYB0	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:Q9Y468	Human	PMID:21149733
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:P25205	Human	PMID:22540012
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:P33992	Human	PMID:22540012
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:P33993	Human	PMID:22540012
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:Q14566	Human	PMID:22540012
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:Q9BTE3	Human	PMID:22540012
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:P33993	Human	PMID:23764002
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:Q9BTE3	Human	PMID:24299456
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:Q08945	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:Q9Y294	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:Q9BTE3	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:Q14566	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:O75419	Human	PMID:26167883
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:P25205	Human	PMID:26167883
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:P49450	Human	PMID:26167883
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:P62805	Human	PMID:26167883
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:P68431	Human	PMID:26167883
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:Q14566	Human	PMID:26167883
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:Q9Y294	Human	PMID:26167883
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:Q14566	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:P53350	Human	PMID:27173435
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:P12004,UniProtKB:P33993,UniProtKB:Q7Z2Z1,UniProtKB:Q9NYP3	Human	PMID:28191891
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:P25205	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:P62805	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:P68431	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:Q08945	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:Q9Y294	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:P25205	Human	PMID:31467278
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:Q9Y294	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MCM2	IPI	UniProtKB:Q8WXX5	Human	PMID:33857403
Cellular Component	GO:0000785	chromatin	MCM2	IDA		Human	PMID:16899510
Cellular Component	GO:0000781	chromosome, telomeric region	MCM2	HDA		Human	PMID:19135898
Cellular Component	GO:0071162	CMG complex	MCM2	IPI		Human	PMID:22474384
Cellular Component	GO:0005737	cytoplasm	MCM2	IDA		Human	PMID:26196677
Cellular Component	GO:0042555	MCM complex	MCM2	IPI		Human	PMID:22540012
Cellular Component	GO:0042555	MCM complex	MCM2	IDA		Human	PMID:17296731
Cellular Component	GO:0042555	MCM complex	Mcm2	IDA		Mouse	MGI:MGI:1353541|PMID:10567526
Cellular Component	GO:0005664	nuclear origin of replication recognition complex	Mcm2	IDA		Mouse	PMID:12941272
Cellular Component	GO:0005654	nucleoplasm	MCM2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	MCM2	IDA		Human	PMID:16899510
Cellular Component	GO:0005634	nucleus	MCM2	IDA		Human	PMID:21383955
Cellular Component	GO:0005634	nucleus	MCM2	IDA		Human	PMID:22474384
Cellular Component	GO:0005634	nucleus	Mcm2	IDA		Mouse	PMID:10531422
Cellular Component	GO:0005634	nucleus	Mcm2	IDA		Mouse	PMID:24367100
Cellular Component	GO:0005634	nucleus	Mcm2	IDA		Rat	PMID:17931356|RGD:10412049
Biological Process	GO:0006915	apoptotic process	MCM2	IMP		Human	PMID:26196677
Biological Process	GO:0071353	cellular response to interleukin-4	Mcm2	IDA		Mouse	PMID:9798653
Biological Process	GO:0090102	cochlea development	MCM2	IMP		Human	PMID:26196677
Biological Process	GO:0006270	DNA replication initiation	MCM2	IMP		Human	PMID:16899510
Biological Process	GO:0006268	DNA unwinding involved in DNA replication	MCM2	IDA		Human	PMID:22474384
Biological Process	GO:0006268	DNA unwinding involved in DNA replication	Mcm2	IDA		Mouse	PMID:10531422
Biological Process	GO:0006334	nucleosome assembly	Mcm2	IDA		Mouse	PMID:10531422
Biological Process	GO:1902017	regulation of cilium assembly	mcm2	IMP	ZFIN:ZDB-MRPHLNO-190530-3	Zfish	PMID:30329080
Biological Process	GO:0060041	retina development in camera-type eye	mcm2	IMP	ZFIN:ZDB-GENO-040312-3	Zfish	PMID:15716491
Biological Process	GO:0060041	retina development in camera-type eye	mcm2	IMP	ZFIN:ZDB-GENO-020430-2	Zfish	PMID:15716491
Biological Process	GO:0048538	thymus development	mcm2	IMP	ZFIN:ZDB-MRPHLNO-130213-3	Zfish	PMID:23213226

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern