Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MCM4
  • Mouse genes Mcm4
  • Rat genes Mcm4
  • Zfish genes mcm4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mcm4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	mcm4	IDA		Zfish	PMID:18974873
Molecular Function	GO:0003678	DNA helicase activity	MCM4	IDA		Human	PMID:25661590
Molecular Function	GO:0003678	DNA helicase activity	MCM4	IDA		Human	PMID:9305914
Molecular Function	GO:0003678	DNA helicase activity	Mcm4	IMP		Mouse	MGI:MGI:1353541|PMID:10567526
Molecular Function	GO:0003678	DNA helicase activity	Mcm4	IMP		Mouse	MGI:MGI:2429455|PMID:12207017
Molecular Function	GO:0003678	DNA helicase activity	Mcm4	IDA		Mouse	PMID:15917436
Molecular Function	GO:0005515	protein binding	MCM4	IPI	UniProtKB:P33993	Human	PMID:12364596
Molecular Function	GO:0005515	protein binding	MCM4	IPI	UniProtKB:P33993	Human	PMID:15232106
Molecular Function	GO:0005515	protein binding	MCM4	IPI	UniProtKB:Q08945	Human	PMID:16902406
Molecular Function	GO:0005515	protein binding	MCM4	IPI	UniProtKB:Q9Y5B9	Human	PMID:16902406
Molecular Function	GO:0005515	protein binding	MCM4	IPI	UniProtKB:P33993	Human	PMID:17296731
Molecular Function	GO:0005515	protein binding	MCM4	IPI	UniProtKB:Q9BTE3	Human	PMID:17296731
Molecular Function	GO:0005515	protein binding	MCM4	IPI	UniProtKB:Q9Q2G4	Human	PMID:22190034
Molecular Function	GO:0005515	protein binding	MCM4	IPI	UniProtKB:P33993	Human	PMID:22540012
Molecular Function	GO:0005515	protein binding	MCM4	IPI	UniProtKB:Q9BTE3	Human	PMID:22540012
Molecular Function	GO:0005515	protein binding	MCM4	IPI	UniProtKB:P33993	Human	PMID:23764002
Molecular Function	GO:0005515	protein binding	MCM4	IPI	UniProtKB:P33993	Human	PMID:24299456
Molecular Function	GO:0005515	protein binding	MCM4	IPI	UniProtKB:Q9BTE3	Human	PMID:24299456
Molecular Function	GO:0005515	protein binding	MCM4	IPI	UniProtKB:Q9ULZ3	Human	PMID:24407287
Molecular Function	GO:0005515	protein binding	MCM4	IPI	UniProtKB:Q9BTE3	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	MCM4	IPI	UniProtKB:Q08945	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	Mcm4	IPI	PR:Q61881	Mouse	PMID:15917436
Molecular Function	GO:0005515	protein binding	Mcm4	IPI	PR:P97311	Mouse	PMID:15917436
Molecular Function	GO:0003697	single-stranded DNA binding	MCM4	IDA		Human	PMID:25661590
Molecular Function	GO:0003697	single-stranded DNA binding	Mcm4	IMP		Mouse	MGI:MGI:2429455|PMID:12207017
Molecular Function	GO:0003697	single-stranded DNA binding	Mcm4	IMP		Mouse	MGI:MGI:1353541|PMID:10567526
Molecular Function	GO:0003697	single-stranded DNA binding	Mcm4	IPI	PR:P97311	Mouse	PMID:15917436
Molecular Function	GO:0003697	single-stranded DNA binding	Mcm4	IPI	PR:Q61881	Mouse	PMID:15917436
Cellular Component	GO:0000781	chromosome, telomeric region	MCM4	HDA		Human	PMID:19135898
Cellular Component	GO:0071162	CMG complex	MCM4	IPI		Human	PMID:22474384
Cellular Component	GO:0042555	MCM complex	MCM4	IPI		Human	PMID:22540012
Cellular Component	GO:0042555	MCM complex	MCM4	IDA		Human	PMID:17296731
Cellular Component	GO:0042555	MCM complex	MCM4	IDA		Human	PMID:25661590
Cellular Component	GO:0042555	MCM complex	Mcm4	IDA		Mouse	MGI:MGI:2429455|PMID:12207017
Cellular Component	GO:0042555	MCM complex	Mcm4	IDA		Mouse	MGI:MGI:1353541|PMID:10567526
Cellular Component	GO:0016020	membrane	MCM4	HDA		Human	PMID:19946888
Cellular Component	GO:0005654	nucleoplasm	MCM4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	MCM4	IDA		Human	PMID:22474384
Biological Process	GO:0006268	DNA unwinding involved in DNA replication	MCM4	IDA		Human	PMID:22474384
Biological Process	GO:0006268	DNA unwinding involved in DNA replication	Mcm4	IPI	PR:P97311	Mouse	PMID:15917436
Biological Process	GO:0006268	DNA unwinding involved in DNA replication	Mcm4	IPI	PR:Q61881	Mouse	PMID:15917436
Biological Process	GO:0001878	response to yeast	mcm4	IDA		Zfish	PMID:23947337

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern