Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MCM8
  • Mouse genes Mcm8
  • Rat genes Mcm8
  • Zfish genes mcm8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mcm8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	MCM8	IDA		Human	PMID:23401855
Molecular Function	GO:0019899	enzyme binding	MCM8	IPI	UniProtKB:Q9NXL9	Human	PMID:23401855
Molecular Function	GO:0019899	enzyme binding	MCM8	IPI	UniProtKB:Q9NXL9	Human	PMID:26215093
Molecular Function	GO:0019899	enzyme binding	MCM8	IPI	UniProtKB:Q9NXL9	Human	PMID:26300262
Molecular Function	GO:0032406	MutLbeta complex binding	MCM8	IDA		Human	PMID:26300262
Molecular Function	GO:0032407	MutSalpha complex binding	MCM8	IDA		Human	PMID:26300262
Molecular Function	GO:0032408	MutSbeta complex binding	MCM8	IDA		Human	PMID:26300262
Molecular Function	GO:0005515	protein binding	MCM8	IPI	UniProtKB:Q9BTE3	Human	PMID:22540012
Molecular Function	GO:0005515	protein binding	MCM8	IPI	UniProtKB:Q06609	Human	PMID:23401855
Molecular Function	GO:0005515	protein binding	MCM8	IPI	UniProtKB:Q9BTE3	Human	PMID:24299456
Molecular Function	GO:0005515	protein binding	MCM8	IPI	UniProtKB:Q9BTE3	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	MCM8	IPI	UniProtKB:P40692|UniProtKB:P43246	Human	PMID:26300262
Molecular Function	GO:0005515	protein binding	MCM8	IPI	UniProtKB:Q9NXL9	Human	PMID:26300262
Molecular Function	GO:0005515	protein binding	MCM8	IPI	UniProtKB:Q8N3J3	Human	PMID:31467087
Cellular Component	GO:0097362	MCM8-MCM9 complex	MCM8	IPI		Human	PMID:26300262
Cellular Component	GO:0097362	MCM8-MCM9 complex	MCM8	IDA		Human	PMID:22771115
Cellular Component	GO:0097362	MCM8-MCM9 complex	MCM8	IDA		Human	PMID:23401855
Cellular Component	GO:0097362	MCM8-MCM9 complex	MCM8	IDA		Human	PMID:26215093
Cellular Component	GO:0097362	MCM8-MCM9 complex	MCM8	IDA		Human	PMID:26300262
Cellular Component	GO:0097362	MCM8-MCM9 complex	Mcm8	IDA		Mouse	MGI:MGI:5437561|PMID:22771120
Cellular Component	GO:0005634	nucleus	MCM8	IDA		Human	PMID:23401855
Cellular Component	GO:0005634	nucleus	MCM8	IDA		Human	PMID:26300262
Biological Process	GO:0006974	DNA damage response	MCM8	IDA		Human	PMID:22771115
Biological Process	GO:0006974	DNA damage response	Mcm8	IMP		Mouse	MGI:MGI:5437561|PMID:22771120
Biological Process	GO:0032508	DNA duplex unwinding	MCM8	IDA		Human	PMID:26300262
Biological Process	GO:0000724	double-strand break repair via homologous recombination	MCM8	IMP		Human	PMID:23401855
Biological Process	GO:0000724	double-strand break repair via homologous recombination	Mcm8	IMP		Mouse	MGI:MGI:5437561|PMID:22771120
Biological Process	GO:0007292	female gamete generation	Mcm8	IMP		Mouse	MGI:MGI:5437561|PMID:22771120
Biological Process	GO:0048232	male gamete generation	Mcm8	IMP		Mouse	MGI:MGI:5437561|PMID:22771120
Biological Process	GO:0071168	protein localization to chromatin	MCM8	IMP		Human	PMID:23401855
Biological Process	GO:0050821	protein stabilization	MCM8	IMP		Human	PMID:23401855
Biological Process	GO:0050821	protein stabilization	MCM8	IMP		Human	PMID:26215093
Biological Process	GO:0036298	recombinational interstrand cross-link repair	MCM8	IMP		Human	PMID:23401855

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern