Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MCOLN1
  • Mouse genes Mcoln1
  • Rat genes Mcoln1
  • Zfish genes mcoln1a,mcoln1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mcoln1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	MCOLN1	IPI	UniProtKB:Q9GZU1	Human	PMID:29019983
Molecular Function	GO:0042802	identical protein binding	MCOLN1	IPI	UniProtKB:Q9GZU1	Human	PMID:30305615
Molecular Function	GO:0097682	intracellular phosphatidylinositol-3,5-bisphosphate-sensitive monatomic cation channel activity	Mcoln1	IDA		Mouse	MGI:MGI:6103412|PMID:29019981
Molecular Function	GO:0099604	ligand-gated calcium channel activity	MCOLN1	IDA		Human	PMID:25720963
Molecular Function	GO:0099604	ligand-gated calcium channel activity	MCOLN1	IDA		Human	PMID:29019983
Molecular Function	GO:0072345	NAADP-sensitive calcium-release channel activity	Mcoln1	IDA		Rat	PMID:17613490|RGD:7205504
Molecular Function	GO:0005515	protein binding	MCOLN1	IPI	UniProtKB:Q13571|UniProtKB:Q15012|UniProtKB:Q86VI4	Human	PMID:21224396
Molecular Function	GO:0005515	protein binding	MCOLN1	IPI	UniProtKB:Q92624	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MCOLN1	IPI	UniProtKB:Q96IW7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Mcoln1	IPI	UniProtKB:Q8C996	Mouse	PMID:25130899
Cellular Component	GO:0005794	Golgi apparatus	MCOLN1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	MCOLN1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0097708	intracellular vesicle	Mcoln1	EXP		Mouse	PMID:25130899
Cellular Component	GO:0005770	late endosome	MCOLN1	IDA		Human	PMID:21224396
Cellular Component	GO:0005770	late endosome	mcoln1a	IDA		Zfish	PMID:23585356
Cellular Component	GO:0005770	late endosome	mcoln1b	IDA		Zfish	PMID:23585356
Cellular Component	GO:0005765	lysosomal membrane	MCOLN1	IDA		Human	PMID:25720963
Cellular Component	GO:0005765	lysosomal membrane	MCOLN1	HDA		Human	PMID:17897319
Cellular Component	GO:0005765	lysosomal membrane	Mcoln1	IDA		Rat	PMID:17613490|RGD:7205504
Cellular Component	GO:0005764	lysosome	MCOLN1	IDA		Human	PMID:21224396
Cellular Component	GO:0005764	lysosome	mcoln1a	IDA		Zfish	PMID:23585356
Cellular Component	GO:0005764	lysosome	mcoln1b	IDA		Zfish	PMID:23585356
Cellular Component	GO:0016020	membrane	MCOLN1	IDA		Human	PMID:29019983
Cellular Component	GO:0016020	membrane	Mcoln1	IDA		Mouse	MGI:MGI:6103412|PMID:29019981
Cellular Component	GO:0005654	nucleoplasm	MCOLN1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043235	receptor complex	MCOLN1	IDA		Human	PMID:23382219
Biological Process	GO:0097352	autophagosome maturation	Mcoln1	IMP	MGI:MGI:3794204	Mouse	PMID:20600908
Biological Process	GO:0006914	autophagy	mcoln1a	IGI	ZFIN:ZDB-GENO-180409-5	Zfish	PMID:28449103
Biological Process	GO:0006914	autophagy	mcoln1b	IGI	ZFIN:ZDB-GENO-180409-5	Zfish	PMID:28449103
Biological Process	GO:1901660	calcium ion export	MCOLN1	IDA		Human	PMID:25720963
Biological Process	GO:0070588	calcium ion transmembrane transport	MCOLN1	IDA		Human	PMID:29019983
Biological Process	GO:0071277	cellular response to calcium ion	Mcoln1	IMP		Mouse	MGI:MGI:6103412|PMID:29019981
Biological Process	GO:0071467	cellular response to pH	Mcoln1	IMP		Mouse	MGI:MGI:6103412|PMID:29019981
Biological Process	GO:0098655	monoatomic cation transmembrane transport	Mcoln1	IDA		Mouse	MGI:MGI:6103412|PMID:29019981
Biological Process	GO:0035675	neuromast hair cell development	mcoln1a	IGI	ZFIN:ZDB-GENO-180409-5	Zfish	PMID:28449103
Biological Process	GO:0035675	neuromast hair cell development	mcoln1b	IGI	ZFIN:ZDB-GENO-180409-5	Zfish	PMID:28449103
Biological Process	GO:0090382	phagosome maturation	MCOLN1	IDA		Human	PMID:27623384
Biological Process	GO:0090382	phagosome maturation	Mcoln1	IDA		Mouse	MGI:MGI:6436407|PMID:27623384
Biological Process	GO:1905673	positive regulation of lysosome organization	MCOLN1	IDA		Human	PMID:25720963
Biological Process	GO:0051289	protein homotetramerization	MCOLN1	IDA		Human	PMID:29019983
Biological Process	GO:0051289	protein homotetramerization	Mcoln1	IDA		Mouse	MGI:MGI:6103412|PMID:29019981
Biological Process	GO:1902822	regulation of late endosome to lysosome transport	mcoln1a	IMP	ZFIN:ZDB-GENO-191218-5	Zfish	PMID:30897512
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	Mcoln1	IDA		Rat	PMID:17613490|RGD:7205504
Biological Process	GO:0001895	retina homeostasis	mcoln1a	IGI	ZFIN:ZDB-GENO-180409-5	Zfish	PMID:28449103
Biological Process	GO:0001895	retina homeostasis	mcoln1b	IGI	ZFIN:ZDB-GENO-180409-5	Zfish	PMID:28449103

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern