Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Mcu

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes MCU
- Mouse genes Mcu
- Rat genes Mcu
- Zfish genes mcu
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mcu

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005262	calcium channel activity	MCU	IDA		Human	PMID:21685888
Molecular Function	GO:0005262	calcium channel activity	MCU	IMP		Human	PMID:23755363
Molecular Function	GO:0005262	calcium channel activity	MCU	IDA		Human	PMID:24560927
Molecular Function	GO:0042802	identical protein binding	mcu	IPI	UniProtKB:Q08BI9	Zfish	PMID:29995857\|ZFIN:ZDB-PUB-180713-9
Molecular Function	GO:0005515	protein binding	MCU	IPI	UniProtKB:Q9BPX6	Human	PMID:21685886
Molecular Function	GO:0005515	protein binding	MCU	IPI	UniProtKB:Q9BPX6	Human	PMID:23101630
Molecular Function	GO:0005515	protein binding	MCU	IPI	UniProtKB:Q96AQ8	Human	PMID:23178883
Molecular Function	GO:0005515	protein binding	MCU	IPI	UniProtKB:Q9BPX6	Human	PMID:23178883
Molecular Function	GO:0005515	protein binding	MCU	IPI	UniProtKB:Q9BV35	Human	PMID:24430870
Molecular Function	GO:0005515	protein binding	MCU	IPI	UniProtKB:Q9BPX6	Human	PMID:26387864
Molecular Function	GO:0005515	protein binding	MCU	IPI	UniProtKB:Q9H4I9	Human	PMID:27099988
Molecular Function	GO:0005515	protein binding	MCU	IPI	UniProtKB:Q96AQ8	Human	PMID:27184846
Molecular Function	GO:0005515	protein binding	MCU	IPI	UniProtKB:Q9GZT6	Human	PMID:27184846
Molecular Function	GO:0005515	protein binding	MCU	IPI	UniProtKB:Q9BPX6	Human	PMID:32494073
Molecular Function	GO:0005515	protein binding	MCU	IPI	UniProtKB:Q9H4I9	Human	PMID:32494073
Molecular Function	GO:0005515	protein binding	Mcu	IPI	UniProtKB:Q810S1	Mouse	MGI:MGI:5514486\|PMID:23900286
Molecular Function	GO:0015292	uniporter activity	MCU	IDA		Human	PMID:21685886
Molecular Function	GO:0015292	uniporter activity	MCU	IDA		Human	PMID:21685888
Molecular Function	GO:0015292	uniporter activity	MCU	IMP		Human	PMID:23755363
Molecular Function	GO:0015292	uniporter activity	MCU	IDA		Human	PMID:24560927
Molecular Function	GO:0015292	uniporter activity	Mcu	IDA		Rat	PMID:16920631\|RGD:7175075
Molecular Function	GO:0015292	uniporter activity	Mcu	IMP		Rat	PMID:22425903\|RGD:7175069
Cellular Component	GO:0034704	calcium channel complex	MCU	IDA		Human	PMID:23755363
Cellular Component	GO:0034704	calcium channel complex	Mcu	IDA		Mouse	MGI:MGI:5487704\|PMID:23409044
Cellular Component	GO:0005743	mitochondrial inner membrane	MCU	IDA		Human	PMID:21685886
Cellular Component	GO:0005743	mitochondrial inner membrane	MCU	IDA		Human	PMID:21685888
Cellular Component	GO:0005743	mitochondrial inner membrane	MCU	IDA		Human	PMID:23755363
Cellular Component	GO:0005743	mitochondrial inner membrane	MCU	IDA		Human	PMID:24231807
Cellular Component	GO:0005743	mitochondrial inner membrane	MCU	IDA		Human	PMID:27099988
Cellular Component	GO:0005743	mitochondrial inner membrane	Mcu	IDA		Rat	PMID:16920631\|RGD:7175075
Cellular Component	GO:0005739	mitochondrion	MCU	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	Mcu	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Mcu	IDA		Rat	PMID:22425903\|RGD:7175069
Cellular Component	GO:1990246	uniplex complex	MCU	IPI		Human	PMID:32494073
Cellular Component	GO:1990246	uniplex complex	MCU	IDA		Human	PMID:22925203
Cellular Component	GO:1990246	uniplex complex	MCU	IDA		Human	PMID:24231807
Cellular Component	GO:1990246	uniplex complex	MCU	IDA		Human	PMID:24560927
Biological Process	GO:0007015	actin filament organization	mcu	IMP	ZFIN:ZDB-MRPHLNO-140604-3	Zfish	PMID:23942336
Biological Process	GO:0090527	actin filament reorganization	MCU	IMP		Human	PMID:28388446
Biological Process	GO:0036444	calcium import into the mitochondrion	MCU	IDA		Human	PMID:22925203
Biological Process	GO:0036444	calcium import into the mitochondrion	MCU	IMP		Human	PMID:23755363
Biological Process	GO:0036444	calcium import into the mitochondrion	MCU	IDA		Human	PMID:32494073
Biological Process	GO:0036444	calcium import into the mitochondrion	mcu	IMP	ZFIN:ZDB-GENO-220517-4	Zfish	PMID:32994451
Biological Process	GO:0036444	calcium import into the mitochondrion	mcu	IMP	ZFIN:ZDB-GENO-220628-1	Zfish	PMID:33424641
Biological Process	GO:0036444	calcium import into the mitochondrion	mcu	IDA		Zfish	PMID:29995857
Biological Process	GO:0019722	calcium-mediated signaling	MCU	IDA		Human	PMID:21685886
Biological Process	GO:0019722	calcium-mediated signaling	MCU	IDA		Human	PMID:21685888
Biological Process	GO:0043009	chordate embryonic development	mcu	IMP	ZFIN:ZDB-MRPHLNO-140604-3	Zfish	PMID:23942336
Biological Process	GO:0060027	convergent extension involved in gastrulation	mcu	IMP	ZFIN:ZDB-MRPHLNO-140604-3	Zfish	PMID:23942336
Biological Process	GO:0051649	establishment of localization in cell	mcu	IMP	ZFIN:ZDB-GENO-220517-4	Zfish	PMID:32994451
Biological Process	GO:0042593	glucose homeostasis	MCU	IMP		Human	PMID:22829870
Biological Process	GO:0051560	mitochondrial calcium ion homeostasis	MCU	IDA		Human	PMID:32494073
Biological Process	GO:0051560	mitochondrial calcium ion homeostasis	Mcu	IMP		Rat	PMID:22425903\|RGD:7175069
Biological Process	GO:0051560	mitochondrial calcium ion homeostasis	mcu	IMP	ZFIN:ZDB-GENO-200519-1	Zfish	PMID:31548178
Biological Process	GO:0006851	mitochondrial calcium ion transmembrane transport	MCU	IMP		Human	PMID:21685886
Biological Process	GO:0006851	mitochondrial calcium ion transmembrane transport	MCU	IDA		Human	PMID:21685888
Biological Process	GO:0006851	mitochondrial calcium ion transmembrane transport	MCU	IMP		Human	PMID:23755363
Biological Process	GO:0006851	mitochondrial calcium ion transmembrane transport	MCU	IDA		Human	PMID:24560927
Biological Process	GO:0006851	mitochondrial calcium ion transmembrane transport	Mcu	IMP		Mouse	MGI:MGI:5141333\|PMID:21685886
Biological Process	GO:0006851	mitochondrial calcium ion transmembrane transport	Mcu	IDA		Rat	PMID:16920631\|RGD:7175075
Biological Process	GO:0006851	mitochondrial calcium ion transmembrane transport	Mcu	IMP		Rat	PMID:22425903\|RGD:7175069
Biological Process	GO:0032024	positive regulation of insulin secretion	MCU	IMP		Human	PMID:22829870
Biological Process	GO:0051561	positive regulation of mitochondrial calcium ion concentration	MCU	IMP		Human	PMID:21685886
Biological Process	GO:0051561	positive regulation of mitochondrial calcium ion concentration	MCU	IDA		Human	PMID:21685888
Biological Process	GO:0051561	positive regulation of mitochondrial calcium ion concentration	MCU	IMP		Human	PMID:23755363
Biological Process	GO:0051561	positive regulation of mitochondrial calcium ion concentration	MCU	IDA		Human	PMID:24560927
Biological Process	GO:0051561	positive regulation of mitochondrial calcium ion concentration	Mcu	IMP		Mouse	MGI:MGI:5141333\|PMID:21685886
Biological Process	GO:0051561	positive regulation of mitochondrial calcium ion concentration	Mcu	IDA		Rat	PMID:16920631\|RGD:7175075
Biological Process	GO:0051561	positive regulation of mitochondrial calcium ion concentration	Mcu	IMP		Rat	PMID:22425903\|RGD:7175069
Biological Process	GO:0090141	positive regulation of mitochondrial fission	MCU	IMP		Human	PMID:28388446
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	MCU	IMP		Human	PMID:28388446
Biological Process	GO:0051259	protein complex oligomerization	MCU	IDA		Human	PMID:21685886
Biological Process	GO:0008016	regulation of heart contraction	mcu	IMP	ZFIN:ZDB-GENO-220628-1	Zfish	PMID:33424641
Biological Process	GO:0008016	regulation of heart contraction	mcu	IGI	ZFIN:ZDB-GENO-980202-1494,ZFIN:ZDB-MRPHLNO-150506-1	Zfish	PMID:25588501

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/09/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.