Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MDH2
  • Mouse genes Mdh2
  • Rat genes Mdh2
  • Zfish genes mdh2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mdh2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030060	L-malate dehydrogenase activity	MDH2	EXP		Human	PMID:16740313
Molecular Function	GO:0030060	L-malate dehydrogenase activity	MDH2	IDA		Human	PMID:16740313
Molecular Function	GO:0030060	L-malate dehydrogenase activity	MDH2	IDA		Human	PMID:27989324
Molecular Function	GO:0030060	L-malate dehydrogenase activity	MDH2	IMP		Human	PMID:6576816
Molecular Function	GO:0030060	L-malate dehydrogenase activity	Mdh2	IDA		Mouse	PMID:1203052
Molecular Function	GO:0030060	L-malate dehydrogenase activity	Mdh2	IDA		Mouse	PMID:24134846
Molecular Function	GO:0030060	L-malate dehydrogenase activity	Mdh2	IDA		Mouse	PMID:5496232
Molecular Function	GO:0030060	L-malate dehydrogenase activity	Mdh2	IDA		Rat	PMID:12351438|RGD:2303499
Molecular Function	GO:0030060	L-malate dehydrogenase activity	Mdh2	IDA		Rat	PMID:938457|RGD:2306828
Molecular Function	GO:0046554	malate dehydrogenase (NADP+) activity	Mdh2	IDA		Rat	PMID:16737718|RGD:1582403
Molecular Function	GO:0016615	malate dehydrogenase activity	Mdh2	IDA		Rat	PMID:1898089|RGD:1582472
Molecular Function	GO:0005515	protein binding	Mdh2	IPI	RGD:11020	Rat	PMID:15809022|RGD:1582471
Molecular Function	GO:0043621	protein self-association	Mdh2	IDA		Rat	PMID:3580173|RGD:1582473
Molecular Function	GO:0003723	RNA binding	MDH2	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	MDH2	HDA		Human	PMID:22681889
Cellular Component	GO:0070062	extracellular exosome	MDH2	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	MDH2	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	MDH2	HDA		Human	PMID:23533145
Cellular Component	GO:0016020	membrane	Mdh2	IMP		Mouse	MGI:MGI:4420830|PMID:20080761
Cellular Component	GO:0005743	mitochondrial inner membrane	Mdh2	HDA		Mouse	PMID:12865426
Cellular Component	GO:0005759	mitochondrial matrix	Mdh2	IDA		Mouse	PMID:5496232
Cellular Component	GO:0005759	mitochondrial matrix	Mdh2	IDA		Mouse	PMID:31648943
Cellular Component	GO:0005759	mitochondrial matrix	Mdh2	IDA		Rat	PMID:6409145|RGD:1582474
Cellular Component	GO:0005739	mitochondrion	MDH2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	MDH2	IDA		Human	PMID:16740313
Cellular Component	GO:0005739	mitochondrion	MDH2	HDA		Human	PMID:20833797
Cellular Component	GO:0005739	mitochondrion	Mdh2	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Mdh2	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Mdh2	IDA		Rat	PMID:16737718|RGD:1582403
Cellular Component	GO:0005739	mitochondrion	Mdh2	IDA		Rat	PMID:1898089|RGD:1582472
Cellular Component	GO:0005739	mitochondrion	Mdh2	IDA		Rat	PMID:938457|RGD:2306828
Cellular Component	GO:0043209	myelin sheath	Mdh2	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0005634	nucleus	MDH2	HDA		Human	PMID:21630459
Biological Process	GO:0009060	aerobic respiration	MDH2	IDA		Human	PMID:27989324
Biological Process	GO:0006094	gluconeogenesis	Mdh2	IDA		Mouse	PMID:12581790
Biological Process	GO:0006108	malate metabolic process	MDH2	IDA		Human	PMID:16740313
Biological Process	GO:0006108	malate metabolic process	MDH2	IMP		Human	PMID:6576816
Biological Process	GO:0006108	malate metabolic process	Mdh2	IDA		Rat	PMID:12351438|RGD:2303499
Biological Process	GO:0006108	malate metabolic process	Mdh2	IDA		Rat	PMID:1898089|RGD:1582472
Biological Process	GO:0006108	malate metabolic process	Mdh2	IDA		Rat	PMID:938457|RGD:2306828
Biological Process	GO:0006734	NADH metabolic process	Mdh2	IDA		Rat	PMID:12351438|RGD:2303499
Biological Process	GO:0006107	oxaloacetate metabolic process	Mdh2	IDA		Rat	PMID:938457|RGD:2306828
Biological Process	GO:0006099	tricarboxylic acid cycle	Mdh2	IDA		Mouse	PMID:35063410
Biological Process	GO:0006099	tricarboxylic acid cycle	Mdh2	IDA		Rat	PMID:938457|RGD:2306828

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern