Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Mdk

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes MDK
- Mouse genes Mdk
- Rat genes Mdk
- Zfish genes mdka,mdkb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mdk

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0035374	chondroitin sulfate binding	Mdk	IDA		Mouse	MGI:MGI:6294191\|PMID:10978312
Molecular Function	GO:1904399	heparan sulfate binding	MDK	IDA		Human	PMID:12084985
Molecular Function	GO:0008201	heparin binding	MDK	IDA		Human	PMID:9384573
Molecular Function	GO:0008201	heparin binding	Mdk	IDA		Mouse	MGI:MGI:6294191\|PMID:10978312
Molecular Function	GO:0005515	protein binding	MDK	IPI	UniProtKB:Q62656	Human	PMID:10212223
Molecular Function	GO:0005515	protein binding	MDK	IPI	UniProtKB:A2ARV4	Human	PMID:10772929
Molecular Function	GO:0005515	protein binding	MDK	IPI	UniProtKB:P13595	Human	PMID:10772929
Molecular Function	GO:0005515	protein binding	MDK	IPI	UniProtKB:Q07954	Human	PMID:10772929
Molecular Function	GO:0005515	protein binding	MDK	IPI	UniProtKB:Q91ZX7	Human	PMID:10772929
Molecular Function	GO:0005515	protein binding	MDK	IPI	UniProtKB:P51653	Human	PMID:12084985
Molecular Function	GO:0005515	protein binding	MDK	IPI	UniProtKB:Q64519	Human	PMID:12084985
Molecular Function	GO:0005515	protein binding	MDK	IPI	UniProtKB:P19338	Human	PMID:12147681
Molecular Function	GO:0005515	protein binding	MDK	IPI	UniProtKB:O88572	Human	PMID:12573468
Molecular Function	GO:0005515	protein binding	MDK	IPI	UniProtKB:Q924X6	Human	PMID:12573468
Molecular Function	GO:0005515	protein binding	MDK	IPI	UniProtKB:P05556	Human	PMID:15466886
Molecular Function	GO:0005515	protein binding	MDK	IPI	UniProtKB:P05556,UniProtKB:P13612	Human	PMID:15466886
Molecular Function	GO:0005515	protein binding	MDK	IPI	UniProtKB:P05556,UniProtKB:P23229	Human	PMID:15466886
Molecular Function	GO:0005515	protein binding	MDK	IPI	UniProtKB:P09055	Human	PMID:15466886
Molecular Function	GO:0005515	protein binding	MDK	IPI	UniProtKB:Q04721	Human	PMID:18469519
Molecular Function	GO:0005515	protein binding	MDK	IPI	UniProtKB:P08631-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MDK	IPI	UniProtKB:Q15560	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MDK	IPI	UniProtKB:Q6PL24	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MDK	IPI	UniProtKB:Q8N0V3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MDK	IPI	UniProtKB:Q8TAC2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MDK	IPI	UniProtKB:Q96AL5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MDK	IPI	UniProtKB:Q96C03-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MDK	IPI	UniProtKB:Q9BXS5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MDK	IPI	UniProtKB:Q9UHD9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MDK	IPI	UniProtKB:Q9UMS0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MDK	IPI	UniProtKB:Q9UMX0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Mdk	IPI	UniProtKB:P26260\|UniProtKB:P33671	Mouse	MGI:MGI:6294350\|PMID:9089390
Molecular Function	GO:0005515	protein binding	Mdk	IPI	UniProtKB:Q9ERQ6	Mouse	MGI:MGI:3695948\|PMID:16901907
Cellular Component	GO:0042995	cell projection	Mdk	IDA		Rat	PMID:14991843\|RGD:1582481
Cellular Component	GO:0062023	collagen-containing extracellular matrix	MDK	HDA		Human	PMID:28327460
Cellular Component	GO:0005737	cytoplasm	Mdk	IDA		Rat	PMID:14991843\|RGD:1582481
Cellular Component	GO:0005576	extracellular region	mdkb	IDA		Zfish	PMID:11748832
Cellular Component	GO:0005794	Golgi apparatus	mdka	IDA		Zfish	PMID:25803551\|ZFIN:ZDB-PUB-150325-3
Biological Process	GO:0030325	adrenal gland development	Mdk	IDA		Rat	PMID:11136554\|RGD:62414
Biological Process	GO:0001662	behavioral fear response	Mdk	IMP		Mouse	MGI:MGI:2178952\|PMID:10096022
Biological Process	GO:0007420	brain development	mdkb	IMP		Zfish	PMID:23418741
Biological Process	GO:0007420	brain development	mdkb	IMP		Zfish	PMID:11133157
Biological Process	GO:0016477	cell migration	Mdk	IDA		Rat	PMID:11340082\|RGD:1582484
Biological Process	GO:0021681	cerebellar granular layer development	Mdk	IMP		Mouse	MGI:MGI:2178952\|PMID:10096022
Biological Process	GO:0021987	cerebral cortex development	Mdk	IEP		Mouse	MGI:MGI:2178952\|PMID:10096022
Biological Process	GO:0007010	cytoskeleton organization	Mdk	IMP		Mouse	MGI:MGI:3695948\|PMID:16901907
Biological Process	GO:0030421	defecation	Mdk	IMP		Mouse	MGI:MGI:2178952\|PMID:10096022
Biological Process	GO:0021542	dentate gyrus development	Mdk	IEP		Mouse	MGI:MGI:2178952\|PMID:10096022
Biological Process	GO:0044849	estrous cycle	Mdk	IMP		Mouse	MGI:MGI:3718185\|PMID:17121547
Biological Process	GO:0106091	glial cell projection elongation	Mdk	IDA		Mouse	MGI:MGI:3695948\|PMID:16901907
Biological Process	GO:0021766	hippocampus development	Mdk	IMP		Mouse	MGI:MGI:2178952\|PMID:10096022
Biological Process	GO:0002232	leukocyte chemotaxis involved in inflammatory response	MDK	IMP		Human	PMID:10683378
Biological Process	GO:0002232	leukocyte chemotaxis involved in inflammatory response	Mdk	IMP		Mouse	MGI:MGI:1353777\|PMID:10683378
Biological Process	GO:0002232	leukocyte chemotaxis involved in inflammatory response	Mdk	IMP		Mouse	MGI:MGI:3606557\|PMID:15482347
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Mdk	IMP		Mouse	MGI:MGI:5008226\|PMID:21185956
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	MDK	IMP		Human	PMID:19060126
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	Mdk	IMP		Mouse	MGI:MGI:3837261\|PMID:19060126
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	Mdk	IMP		Mouse	MGI:MGI:3761216\|PMID:17015789
Biological Process	GO:0007162	negative regulation of cell adhesion	Mdk	IDA		Mouse	MGI:MGI:6294191\|PMID:10978312
Biological Process	GO:1904036	negative regulation of epithelial cell apoptotic process	Mdk	IMP		Mouse	MGI:MGI:3487317\|PMID:15509530
Biological Process	GO:0106015	negative regulation of inflammatory response to wounding	Mdk	IMP		Mouse	MGI:MGI:3761216\|PMID:17015789
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	MDK	IDA		Human	PMID:12573468
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Mdk	IMP		Mouse	MGI:MGI:3839096\|PMID:17230638
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Mdk	IDA		Mouse	MGI:MGI:4943836\|PMID:20346117
Biological Process	GO:1901215	negative regulation of neuron death	Mdk	IDA		Mouse	MGI:MGI:4943836\|PMID:20346117
Biological Process	GO:0030279	negative regulation of ossification	Mdk	IMP		Mouse	MGI:MGI:5780844\|PMID:20200993
Biological Process	GO:0045590	negative regulation of regulatory T cell differentiation	MDK	IMP		Human	PMID:22323540
Biological Process	GO:0007399	nervous system development	mdkb	IMP		Zfish	PMID:11133157
Biological Process	GO:0014029	neural crest formation	mdkb	IMP	ZFIN:ZDB-MRPHLNO-080722-1,ZFIN:ZDB-MRPHLNO-080722-2	Zfish	PMID:18058915
Biological Process	GO:0001841	neural tube formation	mdka	IMP	ZFIN:ZDB-MRPHLNO-050531-5	Zfish	PMID:15833916
Biological Process	GO:0048477	oogenesis	Mdk	IMP		Mouse	MGI:MGI:3718185\|PMID:17121547
Biological Process	GO:1905653	positive regulation of artery morphogenesis	Mdk	IMP		Mouse	MGI:MGI:6269002\|PMID:29233575
Biological Process	GO:1905555	positive regulation of blood vessel branching	MDK	IMP		Human	PMID:19060126
Biological Process	GO:0061036	positive regulation of cartilage development	Mdk	IMP		Mouse	MGI:MGI:5693192\|PMID:25551381
Biological Process	GO:0045785	positive regulation of cell adhesion	MDK	IDA		Human	PMID:12084985
Biological Process	GO:0030335	positive regulation of cell migration	MDK	IDA		Human	PMID:15466886
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Mdk	IMP		Mouse	MGI:MGI:2178952\|PMID:10096022
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	MDK	IMP		Human	PMID:18469519
Biological Process	GO:2000347	positive regulation of hepatocyte proliferation	Mdk	IMP		Mouse	MGI:MGI:3606557\|PMID:15482347
Biological Process	GO:0050729	positive regulation of inflammatory response	MDK	IMP		Human	PMID:22323540
Biological Process	GO:0106016	positive regulation of inflammatory response to wounding	Mdk	IMP		Mouse	MGI:MGI:5897914\|PMID:28183532
Biological Process	GO:0106016	positive regulation of inflammatory response to wounding	Mdk	IMP		Mouse	MGI:MGI:5568278\|PMID:24458438
Biological Process	GO:0032735	positive regulation of interleukin-12 production	MDK	IMP		Human	PMID:22323540
Biological Process	GO:0010838	positive regulation of keratinocyte proliferation	MDK	IDA		Human	PMID:18469519
Biological Process	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell	Mdk	IMP		Mouse	MGI:MGI:5568278\|PMID:24458438
Biological Process	GO:1903039	positive regulation of leukocyte cell-cell adhesion	MDK	IMP		Human	PMID:24458438
Biological Process	GO:0002690	positive regulation of leukocyte chemotaxis	Mdk	IMP		Mouse	MGI:MGI:3606557\|PMID:15482347
Biological Process	GO:0002690	positive regulation of leukocyte chemotaxis	Mdk	IMP		Mouse	MGI:MGI:5897914\|PMID:28183532
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis	MDK	IMP		Human	PMID:10683378
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis	Mdk	IMP		Mouse	MGI:MGI:1353777\|PMID:10683378
Biological Process	GO:0045931	positive regulation of mitotic cell cycle	mdka	IMP	ZFIN:ZDB-GENO-210223-4	Zfish	PMID:31882403
Biological Process	GO:2000179	positive regulation of neural precursor cell proliferation	Mdk	IMP		Mouse	MGI:MGI:3839096\|PMID:17230638
Biological Process	GO:0045666	positive regulation of neuron differentiation	mdkb	IMP	ZFIN:ZDB-MRPHLNO-080722-1,ZFIN:ZDB-MRPHLNO-080722-2	Zfish	PMID:18058915
Biological Process	GO:2001224	positive regulation of neuron migration	MDK	IMP		Human	PMID:10212223
Biological Process	GO:0010976	positive regulation of neuron projection development	MDK	IDA		Human	PMID:12084985
Biological Process	GO:0010976	positive regulation of neuron projection development	MDK	IMP		Human	PMID:15466886
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	Mdk	IMP		Mouse	MGI:MGI:3487317\|PMID:15509530
Biological Process	GO:2000391	positive regulation of neutrophil extravasation	Mdk	IMP		Mouse	MGI:MGI:5568278\|PMID:24458438
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	MDK	IDA		Human	PMID:27445335
Biological Process	GO:0071673	positive regulation of smooth muscle cell chemotaxis	MDK	IMP		Human	PMID:10683378
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	Mdk	IMP		Mouse	MGI:MGI:3695948\|PMID:16901907
Biological Process	GO:0045582	positive regulation of T cell differentiation	Mdk	IMP		Mouse	MGI:MGI:5897914\|PMID:28183532
Biological Process	GO:1905564	positive regulation of vascular endothelial cell proliferation	Mdk	IMP		Mouse	MGI:MGI:6269002\|PMID:29233575
Biological Process	GO:2000249	regulation of actin cytoskeleton reorganization	MDK	IDA		Human	PMID:18469519
Biological Process	GO:0050795	regulation of behavior	Mdk	IMP		Mouse	MGI:MGI:2178952\|PMID:10096022
Biological Process	GO:0046850	regulation of bone remodeling	Mdk	IMP		Mouse	MGI:MGI:5008226\|PMID:21185956
Biological Process	GO:0051726	regulation of cell cycle	mdka	IMP		Zfish	PMID:23111152\|ZFIN:ZDB-PUB-121120-19
Biological Process	GO:0051726	regulation of cell cycle	mdka	IMP	ZFIN:ZDB-GENO-130416-1	Zfish	PMID:23111152
Biological Process	GO:0051726	regulation of cell cycle	mdka	IMP	ZFIN:ZDB-MRPHLNO-050531-5	Zfish	PMID:23111152
Biological Process	GO:0032330	regulation of chondrocyte differentiation	Mdk	IMP		Mouse	MGI:MGI:5693192\|PMID:25551381
Biological Process	GO:0010996	response to auditory stimulus	Mdk	IMP		Mouse	MGI:MGI:3640442\|PMID:16619002
Biological Process	GO:0051384	response to glucocorticoid	Mdk	IEP		Rat	PMID:12495930\|RGD:1582482
Biological Process	GO:0009725	response to hormone	Mdk	IEP		Rat	PMID:7720861\|RGD:1582489
Biological Process	GO:0009611	response to wounding	Mdk	IDA		Mouse	MGI:MGI:1353777\|PMID:10683378
Biological Process	GO:0009611	response to wounding	Mdk	IDA		Rat	PMID:10683378\|RGD:1299187
Biological Process	GO:0009410	response to xenobiotic stimulus	Mdk	IEP		Rat	PMID:15315716\|RGD:1582479
Biological Process	GO:0070654	sensory epithelium regeneration	mdka	IMP	ZFIN:ZDB-MRPHLNO-050531-5	Zfish	PMID:25803551
Biological Process	GO:0007614	short-term memory	Mdk	IMP		Mouse	MGI:MGI:2178952\|PMID:10096022
Biological Process	GO:0002286	T cell activation involved in immune response	Mdk	IMP		Mouse	MGI:MGI:5897914\|PMID:28183532
Biological Process	GO:0042246	tissue regeneration	Mdk	IMP		Mouse	MGI:MGI:3606557\|PMID:15482347

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.