Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Med12

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes MED12
- Mouse genes Med12
- Rat genes Med12
- Zfish genes med12
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Med12

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Med12	IDA		Mouse	PMID:20720539
Molecular Function	GO:0140587	chromatin loop anchoring activity	med12	IMP	ZFIN:ZDB-MRPHLNO-080819-1	Zfish	PMID:25255084
Molecular Function	GO:0140587	chromatin loop anchoring activity	med12	IGI	ZFIN:ZDB-MRPHLNO-080819-1,ZFIN:ZDB-MRPHLNO-111201-1,ZFIN:ZDB-MRPHLNO-111201-3	Zfish	PMID:25255084
Molecular Function	GO:0003700	DNA-binding transcription factor activity	med12	IGI	ZFIN:ZDB-GENE-990415-90,ZFIN:ZDB-MRPHLNO-080819-1	Zfish	PMID:18394596
Molecular Function	GO:0046966	nuclear thyroid hormone receptor binding	MED12	IDA		Human	PMID:10198638
Molecular Function	GO:0140585	promoter-enhancer loop anchoring activity	med12	IMP	ZFIN:ZDB-MRPHLNO-080819-1	Zfish	PMID:25255084
Molecular Function	GO:0140585	promoter-enhancer loop anchoring activity	med12	IGI	ZFIN:ZDB-MRPHLNO-080819-1,ZFIN:ZDB-MRPHLNO-111201-1,ZFIN:ZDB-MRPHLNO-111201-3	Zfish	PMID:25255084
Molecular Function	GO:0005515	protein binding	MED12	IPI	UniProtKB:Q99698	Human	PMID:11984006
Molecular Function	GO:0005515	protein binding	MED12	IPI	UniProtKB:P10071	Human	PMID:17000779
Molecular Function	GO:0005515	protein binding	MED12	IPI	UniProtKB:P05067	Human	PMID:21293490
Molecular Function	GO:0005515	protein binding	MED12	IPI	UniProtKB:P51693	Human	PMID:21293490
Molecular Function	GO:0005515	protein binding	MED12	IPI	UniProtKB:Q06481	Human	PMID:21293490
Molecular Function	GO:0005515	protein binding	MED12	IPI	UniProtKB:Q9NPJ6	Human	PMID:21293490
Molecular Function	GO:0005515	protein binding	MED12	IPI	UniProtKB:P37173	Human	PMID:23178117
Molecular Function	GO:0005515	protein binding	MED12	IPI	UniProtKB:Q9NPJ6	Human	PMID:25281560
Molecular Function	GO:0005515	protein binding	MED12	IPI	UniProtKB:Q9NPJ6	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	Med12	IPI	UniProtKB:Q8R3L8	Mouse	MGI:MGI:5615331\|PMID:25344755
Molecular Function	GO:0005515	protein binding	Med12	IPI	UniProtKB:P37173	Mouse	MGI:MGI:5487474\|PMID:23178117
Molecular Function	GO:0005515	protein binding	Med12	IPI	UniProtKB:Q8R3L8	Mouse	MGI:MGI:4833901\|PMID:20720539
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Med12	IDA		Mouse	PMID:23575864
Molecular Function	GO:0003713	transcription coactivator activity	MED12	IDA		Human	PMID:12037571
Molecular Function	GO:0003713	transcription coactivator activity	MED12	IDA		Human	PMID:12218053
Molecular Function	GO:0003713	transcription coactivator activity	Med12	IGI	MGI:MGI:98358	Mouse	PMID:23575864
Molecular Function	GO:0003712	transcription coregulator activity	MED12	IDA		Human	PMID:10198638
Molecular Function	GO:0008134	transcription factor binding	Med12	IPI	PR:Q04888	Mouse	PMID:23575864
Molecular Function	GO:0061630	ubiquitin protein ligase activity	Med12	IDA		Rat	PMID:12149480\|RGD:2304264
Cellular Component	GO:0016592	mediator complex	MED12	IDA		Human	PMID:10198638
Cellular Component	GO:0016592	mediator complex	MED12	IDA		Human	PMID:12037571
Cellular Component	GO:0016592	mediator complex	Med12	IDA		Mouse	PMID:15340084
Cellular Component	GO:0016020	membrane	MED12	HDA		Human	PMID:19946888
Cellular Component	GO:0005634	nucleus	MED12	IDA		Human	PMID:10235267
Cellular Component	GO:0005634	nucleus	MED12	IDA		Human	PMID:17000779
Cellular Component	GO:0000151	ubiquitin ligase complex	Med12	IDA		Rat	PMID:12149480\|RGD:2304264
Biological Process	GO:0090245	axis elongation involved in somitogenesis	Med12	IMP	MGI:MGI:4839484	Mouse	PMID:20630950
Biological Process	GO:0021954	central nervous system neuron development	med12	IMP	ZFIN:ZDB-GENO-070216-1	Zfish	PMID:10191060
Biological Process	GO:0043583	ear development	med12	IMP	ZFIN:ZDB-GENO-980202-990	Zfish	PMID:9007241
Biological Process	GO:1990403	embryonic brain development	Med12	IMP	MGI:MGI:4839485	Mouse	PMID:20589884
Biological Process	GO:0048702	embryonic neurocranium morphogenesis	Med12	IMP	MGI:MGI:4839485	Mouse	PMID:20589884
Biological Process	GO:0048702	embryonic neurocranium morphogenesis	med12	IMP	ZFIN:ZDB-GENO-060823-1	Zfish	PMID:16712834
Biological Process	GO:0048568	embryonic organ development	Med12	IMP	MGI:MGI:4839485	Mouse	PMID:20589884
Biological Process	GO:0035118	embryonic pectoral fin morphogenesis	med12	IMP	ZFIN:ZDB-MRPHLNO-080819-1	Zfish	PMID:25255084
Biological Process	GO:0035118	embryonic pectoral fin morphogenesis	med12	IGI	ZFIN:ZDB-MRPHLNO-080819-1,ZFIN:ZDB-MRPHLNO-111201-1,ZFIN:ZDB-MRPHLNO-111201-3	Zfish	PMID:25255084
Biological Process	GO:0035118	embryonic pectoral fin morphogenesis	med12	IMP	ZFIN:ZDB-GENO-060823-1	Zfish	PMID:16712834
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	med12	IMP	ZFIN:ZDB-GENO-060823-1	Zfish	PMID:16712834
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	med12	IMP	ZFIN:ZDB-GENO-060125-2	Zfish	PMID:16344459
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	med12	IMP	ZFIN:ZDB-GENO-060125-3	Zfish	PMID:16344459
Biological Process	GO:0007492	endoderm development	Med12	IMP	MGI:MGI:4839486	Mouse	PMID:20589884
Biological Process	GO:0007492	endoderm development	med12	IMP	ZFIN:ZDB-GENO-080819-6	Zfish	PMID:18394596
Biological Process	GO:0007492	endoderm development	med12	IMP	ZFIN:ZDB-MRPHLNO-080819-1	Zfish	PMID:18394596
Biological Process	GO:0007492	endoderm development	med12	IMP	ZFIN:ZDB-GENO-080819-3	Zfish	PMID:18394596
Biological Process	GO:0007492	endoderm development	med12	IGI	ZFIN:ZDB-GENO-080819-6,ZFIN:ZDB-MRPHLNO-050228-2	Zfish	PMID:18394596
Biological Process	GO:0030900	forebrain development	med12	IMP	ZFIN:ZDB-GENO-060125-2	Zfish	PMID:16344459
Biological Process	GO:0030900	forebrain development	med12	IMP	ZFIN:ZDB-GENO-060125-3	Zfish	PMID:16344459
Biological Process	GO:0021986	habenula development	med12	IMP	ZFIN:ZDB-GENO-140213-2	Zfish	PMID:24184636
Biological Process	GO:0007507	heart development	Med12	IMP	MGI:MGI:4839484	Mouse	PMID:20630950
Biological Process	GO:0007507	heart development	med12	IMP	ZFIN:ZDB-GENO-980202-990	Zfish	PMID:9007241
Biological Process	GO:0050935	iridophore differentiation	med12	IMP	ZFIN:ZDB-GENO-060823-1	Zfish	PMID:16712834
Biological Process	GO:0001822	kidney development	med12	IMP	ZFIN:ZDB-GENO-060125-2	Zfish	PMID:16344459
Biological Process	GO:0001822	kidney development	med12	IMP	ZFIN:ZDB-GENO-060125-3	Zfish	PMID:16344459
Biological Process	GO:0030901	midbrain development	med12	IMP	ZFIN:ZDB-GENO-060125-2	Zfish	PMID:16344459
Biological Process	GO:0030901	midbrain development	med12	IMP	ZFIN:ZDB-GENO-060125-3	Zfish	PMID:16344459
Biological Process	GO:0014032	neural crest cell development	med12	IMP	ZFIN:ZDB-GENO-060823-1	Zfish	PMID:16712834
Biological Process	GO:0001843	neural tube closure	Med12	IMP	MGI:MGI:4839484	Mouse	PMID:20630950
Biological Process	GO:0021915	neural tube development	Med12	IMP	MGI:MGI:4839485	Mouse	PMID:20589884
Biological Process	GO:0030182	neuron differentiation	med12	IMP	ZFIN:ZDB-GENO-070216-1	Zfish	PMID:17088561
Biological Process	GO:0014003	oligodendrocyte development	Med12	IMP	MGI:MGI:4839485	Mouse	PMID:23575864
Biological Process	GO:0021982	pineal gland development	med12	IMP	ZFIN:ZDB-GENO-140213-2	Zfish	PMID:24184636
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	MED12	IDA		Human	PMID:10198638
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	med12	IGI	ZFIN:ZDB-GENE-990415-90,ZFIN:ZDB-MRPHLNO-080819-1	Zfish	PMID:18394596
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	MED12	IDA		Human	PMID:12037571
Biological Process	GO:0060261	positive regulation of transcription initiation by RNA polymerase II	MED12	IDA		Human	PMID:12218053
Biological Process	GO:0036342	post-anal tail morphogenesis	Med12	IMP	MGI:MGI:4839485	Mouse	PMID:20589884
Biological Process	GO:0016567	protein ubiquitination	Med12	IDA		Rat	PMID:12149480\|RGD:2304264
Biological Process	GO:0002761	regulation of myeloid leukocyte differentiation	med12	IMP	ZFIN:ZDB-MRPHLNO-060823-1	Zfish	PMID:21901140
Biological Process	GO:0002761	regulation of myeloid leukocyte differentiation	med12	IMP	ZFIN:ZDB-GENO-111201-3	Zfish	PMID:21901140
Biological Process	GO:0021654	rhombomere boundary formation	med12	IMP	ZFIN:ZDB-MRPHLNO-060125-1	Zfish	PMID:21533047
Biological Process	GO:0021654	rhombomere boundary formation	med12	IMP	ZFIN:ZDB-GENO-110527-1	Zfish	PMID:21533047
Biological Process	GO:0014044	Schwann cell development	Med12	IMP	MGI:MGI:4839485	Mouse	PMID:23575864
Biological Process	GO:0035019	somatic stem cell population maintenance	Med12	IMP		Mouse	PMID:20720539
Biological Process	GO:0001756	somitogenesis	Med12	IMP	MGI:MGI:4839486	Mouse	PMID:20589884
Biological Process	GO:0021510	spinal cord development	Med12	IMP	MGI:MGI:4839485	Mouse	PMID:20589884
Biological Process	GO:0021591	ventricular system development	med12	IMP	ZFIN:ZDB-GENO-980202-990	Zfish	PMID:9007241
Biological Process	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	Med12	IMP	MGI:MGI:4839486	Mouse	PMID:20630950

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.