Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MED25
  • Mouse genes Med25
  • Rat genes Med25
  • Zfish genes med25
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Med25

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042974	nuclear retinoic acid receptor binding	MED25	IPI	UniProtKB:P10276	Human	PMID:17641689
Molecular Function	GO:0042974	nuclear retinoic acid receptor binding	Med25	IPI	UniProtKB:P11416	Mouse	MGI:MGI:5297783|PMID:17641689
Molecular Function	GO:0046965	nuclear retinoid X receptor binding	MED25	IPI	UniProtKB:P28700	Human	PMID:17641689
Molecular Function	GO:0046965	nuclear retinoid X receptor binding	Med25	IPI	UniProtKB:P28700	Mouse	MGI:MGI:5297783|PMID:17641689
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:O75586	Human	PMID:17641689
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:P10276	Human	PMID:17641689
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:P11416	Human	PMID:17641689
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:P19793	Human	PMID:17641689
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:P28700	Human	PMID:17641689
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:G8HBG2	Human	PMID:21378963
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:G8HBG2	Human	PMID:21378965
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:O60244	Human	PMID:24882805
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:O75448	Human	PMID:24882805
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:Q96RN5	Human	PMID:24882805
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:Q9ULK4	Human	PMID:24882805
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:Q9Y2X0	Human	PMID:24882805
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:Q9ULK4	Human	PMID:25281560
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:O60244	Human	PMID:25792360
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:O75448	Human	PMID:25792360
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:Q9ULK4	Human	PMID:25792360
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:Q9Y2X0	Human	PMID:25792360
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:A1E959	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:A1KXE4-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:O00167-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:O00308	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:O14964	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:P51692	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:Q08117-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:Q14847-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:Q3LI64	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:Q53G59	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:Q6NXG1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:Q70EL1-9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:Q8TDS5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:Q92734	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:Q92753-1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:Q96CS7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:Q9BVN2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:Q9NZC7-5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:Q9NZQ3-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:Q9UBV8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED25	IPI	UniProtKB:Q9UJW9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Med25	IPI	PR:Q9DBH0	Mouse	PMID:21427722
Molecular Function	GO:0001223	transcription coactivator binding	MED25	IPI	UniProtKB:B2RWS6	Human	PMID:17641689
Molecular Function	GO:0001223	transcription coactivator binding	MED25	IPI	UniProtKB:Q15648	Human	PMID:17641689
Cellular Component	GO:0070847	core mediator complex	MED25	IPI		Human	PMID:24882805
Cellular Component	GO:0005654	nucleoplasm	MED25	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	MED25	IDA		Human	PMID:24882805
Cellular Component	GO:0005667	transcription regulator complex	Med25	IPI	PR:Q04887	Mouse	PMID:21427722
Cellular Component	GO:0005667	transcription regulator complex	Med25	IPI	PR:Q9DBH0	Mouse	PMID:21427722
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	MED25	IMP		Human	PMID:17641689
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	MED25	IMP		Human	PMID:17641689
Biological Process	GO:0035563	positive regulation of chromatin binding	MED25	IMP		Human	PMID:17641689
Biological Process	GO:2001178	positive regulation of mediator complex assembly	MED25	IMP		Human	PMID:17641689
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	MED25	IDA		Human	PMID:17641689
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Med25	IGI	MGI:MGI:1914144	Mouse	PMID:21427722
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Med25	IGI	MGI:MGI:98371	Mouse	PMID:21427722
Biological Process	GO:0060021	roof of mouth development	med25	IMP	ZFIN:ZDB-MRPHLNO-120518-4	Zfish	PMID:21427722
Biological Process	GO:0006366	transcription by RNA polymerase II	Med25	IGI	MGI:MGI:1914144	Mouse	PMID:21427722
Biological Process	GO:0006366	transcription by RNA polymerase II	Med25	IGI	MGI:MGI:98371	Mouse	PMID:21427722

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern